DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Flrt1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001102630.1	Gene:	Flrt1 / 499308	RGDID:	1565152	Length:	674	Species:	Rattus norvegicus

Alignment Length:	491	Identity:	120/491 - (24%)
Similarity:	198/491 - (40%)	Gaps:	132/491 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNL----------TKLEANSFFMAPN-- 204
            |.|....    :.|...|:.::|.::|::...|.|.||.:          ||::....::..|
  Rat    58 CRCDNGF----IYCNDRGLTSIPSDIPDDATTLYLQNNQINNAGIPQDLKTKVKVQVIYLYENDL 118

  Fly   205 ----------LEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLK--SLPPQSFQGLAQLTSLQ 257
                      |.||.|.||::..:..::...:..|::|.|.:..:.  |:...:|....||..|.
  Rat   119 DEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLF 183

  Fly   258 LNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLT--IINDEDFP 320
            |:.|.|.|:..   |....|..|||:.|....||.:|..||.:|..|.|..|||.  .|.|:.|.
  Rat   184 LSRNHLSSIPS---GLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFS 245

  Fly   321 RMPNLIVLLLKRNQIMKISAGALKNLTA--LKVLELDDNLISSLP-EGLSKLSQLQELSITSNRL 382
            |:.||..|.|.||.:    |....||.:  |:.|.|.||.||.:| ..|:|:.:|:.|.:::|.|
  Rat   246 RLQNLTELSLVRNSL----AAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNL 306

  Fly   383 RWINDTELPRSM--------QMLDMRANP-------------------LSTISPGAFRGMSKLRK 420
                 |.|||.:        |:| :|.||                   :..:.....:|..|:|.
  Rat   307 -----TTLPRGLFDDLGNLAQLL-LRNNPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRG 365

  Fly   421 LILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQ----------TPR--LKSLELKTN 473
            :.:.|:.:     |::.|.        .||.|...||...:          ||:  |.:|:.|..
  Rat   366 MAIKDITS-----EMDECF--------EAGSQGSAANAAAKTTASNHASATTPQGSLFTLKAKRP 417

  Fly   474 SLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLL 538
            .| |:|:.:....:...|.:...:  ||.||...    :.:.:::..:  ||..:|    :|..|
  Rat   418 GL-RLPDSNIDYPMATGDGAKTLV--IQVKPLTA----DSIRITWKAM--LPASSF----RLSWL 469

  Fly   539 DL--------------EGNEISYIHKEAFSGFTALE 560
            .|              :|::..|:       .||||
  Rat   470 RLGHSPAVGSITETLVQGDKTEYL-------LTALE 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	3/20 (15%)
		LRR_RI	180..>383	CDD:238064	68/231 (29%)
		leucine-rich repeat	183..204	CDD:275380	6/30 (20%)
		LRR_8	203..263	CDD:290566	17/73 (23%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	5/24 (21%)
		LRR_8	252..311	CDD:290566	22/58 (38%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	10/22 (45%)
		LRR_8	299..359	CDD:290566	24/63 (38%)
		leucine-rich repeat	301..324	CDD:275380	10/24 (42%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	66/290 (23%)
		leucine-rich repeat	349..371	CDD:275380	10/22 (45%)
		LRR_8	370..425	CDD:290566	16/81 (20%)
		leucine-rich repeat	372..393	CDD:275380	7/20 (35%)
		leucine-rich repeat	394..415	CDD:275380	5/47 (11%)
		leucine-rich repeat	418..486	CDD:275380	17/79 (22%)
		leucine-rich repeat	441..464	CDD:275378	6/32 (19%)
		LRR_8	487..545	CDD:290566	12/71 (17%)
		leucine-rich repeat	487..510	CDD:275380	5/22 (23%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		LRR_8	533..589	CDD:290566	9/42 (21%)
		leucine-rich repeat	535..558	CDD:275380	5/36 (14%)
		leucine-rich repeat	559..580	CDD:275380	2/2 (100%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Flrt1	NP_001102630.1	PRK15370	<58..>329	CDD:185268	82/287 (29%)
		leucine-rich repeat	108..128	CDD:275380	1/19 (5%)
		leucine-rich repeat	129..152	CDD:275380	6/22 (27%)
		leucine-rich repeat	153..178	CDD:275380	5/24 (21%)
		leucine-rich repeat	179..199	CDD:275380	7/22 (32%)
		leucine-rich repeat	200..223	CDD:275380	10/22 (45%)
		leucine-rich repeat	224..249	CDD:275380	10/24 (42%)
		leucine-rich repeat	250..271	CDD:275380	8/24 (33%)
		leucine-rich repeat	272..295	CDD:275380	10/22 (45%)
		leucine-rich repeat	296..319	CDD:275380	8/27 (30%)
		PCC	300..>386	CDD:188093	20/104 (19%)
		FN3	441..505	CDD:214495	16/75 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910