DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and Phlpp2

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_001102601.2 Gene:Phlpp2 / 498949 RGDID:1562857 Length:1359 Species:Rattus norvegicus


Alignment Length:1533 Identity:316/1533 - (20%)
Similarity:505/1533 - (32%) Gaps:537/1533 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 TKENPAPDMQNSQEQEPYVHLQHLQQQQQQNPQTVQQLSQITVNRTSKSASVTPTGIRENVMLPS 101
            |.|.||.::...:.:|. ::|| |.....:..:..::..||..:..|:.....|..|:|.    :
  Rat   104 TVETPASEICAGEGRES-LYLQ-LHGDLVRRLEPTERPLQIVYDYLSRLGFEDPVRIQEE----A 162

  Fly   102 ADPEKEAQILY--EKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWL-----------QKHCH 153
            .:|:....|.:  ||..|..|..:: ..|...:|..||..||...||.:           .|.|.
  Rat   163 TNPDLSCMIRFYGEKPCQMDHLDRI-LLSGIYNVRKGKTQLHKWAERLVVLCGTCLIVSSVKDCQ 226

  Fly   154 CTGSLEVL--------------------------------------------------------- 161
             ||.:.:|                                                         
  Rat   227 -TGKMHILPLVGGKIEEVKRRQHSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRISTV 290

  Fly   162 RLSCRGIGILAVPVNL--PNEVVVLDLGNNNLTKLE----ANSFFMAPNLEELTLSDNSIINMDP 220
            .|||  ..:..||.:|  ..::..|:| .:|..:||    .::.:....|:.|.||.|. :.:.|
  Rat   291 DLSC--YSLEEVPEHLFYSQDITYLNL-RHNFMQLERPGGLDTLYKFSQLKGLNLSHNK-LGLFP 351

  Fly   221 NAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGN 285
            .....::.|..|:|...|...||.| ...|..|.:|.|:||.|.:|. |.||:||:|.:|.:..|
  Rat   352 VLLCEISTLTELNLSCNGFHDLPSQ-IGNLLNLQTLCLDGNVLTALP-DELGNLQQLTSLGISFN 414

  Fly   286 LFYRIP----------TNALAGLRTLEALNLG---------------SNLLTII----------- 314
            .|.:||          ...:||.| ||.||||               ::|.|:|           
  Rat   415 NFSQIPEVLEKLTMLDKVVMAGNR-LEILNLGVLTRMNHVKHVDLRMNHLKTVIIENLEGNKHIT 478

  Fly   315 ---------NDEDFPRMPNLIVLLLKRNQI--MKISAGALKN-------LTALKV---------L 352
                     .|.|...:.:|..|..:|||:  :.:|..:|:|       |||:.|         |
  Rat   479 HMDLRDNQLTDLDLSSLCSLEQLHCERNQLRELTLSGFSLRNLYANWNKLTAVNVYPVPSLLTSL 543

  Fly   353 ELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSK 417
            ||..||:..:|:...:..:|:.|.|:.|.|     ||:|       ||.  ||::|         
  Rat   544 ELSRNLLECIPDWACEAKKLEILDISYNLL-----TEVP-------MRI--LSSLS--------- 585

  Fly   418 LRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLS 482
            ||||::.. ..:...|.|.....||:|.:....:..:|..|..:...|:.|....|||:.:|  |
  Rat   586 LRKLMVGH-NHIHVLPALVEHIPLEVLDVQHNTLSRLPDTLFSKALNLRYLNASANSLESLP--S 647

  Fly   483 SCR------------------------------DLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLS 517
            :|.                              .||:|.|::||::.......|.|:||.:|.||
  Rat   648 ACAGEESLSVLQLLYLTNNLLTDQCIPVLVGHPHLRVLHLANNQLQTFPASKLNKLEQLEELNLS 712

  Fly   518 YNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPE---LPESGLRA 579
            .|::||:| .......:|..|....|.||                     ||||   ||:     
  Rat   713 GNKLKAIP-TTIANCKRLHTLVAHANNIS---------------------IFPEILQLPQ----- 750

  Fly   580 LLHLKTFNNPKLREFPPPDTFP-RIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAE 643
             :.....:...|.|...|:|.| .:|.|.|:...:.......:.|.|...|.::.:..|..:|:.
  Rat   751 -IQFVDLSCNDLTEILIPETLPATLQDLDLTGNTNLVLEHKTLDMFSHITTLKIDQKPLPTTDST 814

  Fly   644 FDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDV 708
            ...|.|::.:..:..|.:.|.                             ::...|:.:      
  Rat   815 VTSTFWSHGLAEMAGQRNKLC-----------------------------VSALAMDNF------ 844

  Fly   709 SGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGT 773
               |.|.|...|:|.|...|:. |..:||        ..||:              ||..:.:.|
  Rat   845 ---AEGVGAVYGMFDGDRNEEL-PRLLQC--------TMADV--------------LLEEVQHST 883

  Fly   774 --VVFV---LLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLC 833
              .||:   .|.|..|:.:              .|..||..|:                    ||
  Rat   884 SDTVFMANTFLVSHRKLGM--------------AGQKLGSSAL--------------------LC 914

  Fly   834 QLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVG 898
            .:....|..:|..|: |:|      |.....|:       |.:.|..:.:..||:|.........
  Rat   915 YIRPDTADPTSSFSL-TVA------NVGTCQAV-------LCRGGKPVPLSKVFSLEHDPEEAQR 965

  Fly   899 VSDYRKFAVCLPFETTTGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAW-----NTND 958
            |.|.:  |:........|....|.::      ||.:|                ..|     :.:.
  Rat   966 VKDQK--AIITEDNKVNGVTCCTRML------GCTYL----------------YPWILPKPHISS 1006

  Fly   959 SRIAKRMALLVFTDFLCWSPIAFF-SITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTK 1022
            :.:..:..||:..:...|..:::. :::|:..:|                     :|...|    
  Rat  1007 TPLTIQDELLILGNKALWEHLSYLEAVSAVRHVQ---------------------DPLAAA---- 1046

  Fly  1023 QFKKDCVTLCKHFEESRVVGG---------------------GGPGGRGAVARTKRGDLPPPLLP 1066
              ||.| ||.:.:.....||.                     .||.|..:.|..|  |.|.|..|
  Rat  1047 --KKLC-TLAQSYGCQDNVGAMVVYLNIGEEGCTCEMHGLALPGPVGFASTATIK--DAPKPTTP 1106

  Fly  1067 AAA--VAHPPGCRCLRMLPSEMPNWHKMEQTPSMWQRLRTFCCGENRRRRKQRRQPQ-QRRQRAY 1128
            :::  :|..        |.||:.......:..|      |.....|....:....|: :||...:
  Rat  1107 SSSSGIASE--------LSSEVSTSEVSSEVGS------TASDEHNTVGLETSLLPRPERRCSLH 1157

  Fly  1129 TAAAANPYQYQFAELRQQRQNRASSISSEN---------------------------FCSSRSSS 1166
            ...:|..:|      ||......||..|:|                           .|..|.| 
  Rat  1158 PVPSAGTFQ------RQPSCATFSSNQSDNGLDSDDDQPVEGVITNGSRVEVEVDIHCCRGRES- 1215

  Fly  1167 WRHGPPSSAPVPPGNCSMPLKMLEPHAHPHGHGRRRHSAWLITRKTSQDSNLSSSRN-DSSASAT 1230
                  .::|..|.|.|.|..  |.||...|.|        |.|:.|.:|.:....| |......
  Rat  1216 ------ENSPTLPKNSSYPCS--EEHARGLGFG--------IRRQNSVNSGILLPVNKDKMELQK 1264

  Fly  1231 TASTSTFRLSRSSAGSSTPLPSII--------AHNGK-------AQLDA----VKPR----LVRQ 1272
            :.|||.....:.|.||..||...:        |...|       .||:.    |.||    .|::
  Rat  1265 SPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEAPKRKTGYFAAPTQLEPEDQFVVPRDLEDEVKE 1329

  Fly  1273 EAVQEEEDSSPPRLGVRFLPTIPSAADSSVVMEDGDSA 1310
            :..|.:|....|.         |...|.:..:::.|:|
  Rat  1330 QMKQHQESRPEPE---------PREEDRTEPLQEFDTA 1358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 7/79 (9%)
LRR_RI 180..>383 CDD:238064 73/269 (27%)
leucine-rich repeat 183..204 CDD:275380 5/24 (21%)
LRR_8 203..263 CDD:290566 19/59 (32%)
leucine-rich repeat 205..228 CDD:275380 6/22 (27%)
leucine-rich repeat 229..252 CDD:275380 8/22 (36%)
LRR_8 252..311 CDD:290566 27/83 (33%)
leucine-rich repeat 253..276 CDD:275380 11/22 (50%)
leucine-rich repeat 277..300 CDD:275380 8/32 (25%)
LRR_8 299..359 CDD:290566 28/112 (25%)
leucine-rich repeat 301..324 CDD:275380 11/57 (19%)
leucine-rich repeat 325..348 CDD:275380 9/31 (29%)
LRR_RI 327..567 CDD:238064 71/287 (25%)
leucine-rich repeat 349..371 CDD:275380 7/30 (23%)
LRR_8 370..425 CDD:290566 17/54 (31%)
leucine-rich repeat 372..393 CDD:275380 8/20 (40%)
leucine-rich repeat 394..415 CDD:275380 5/20 (25%)
leucine-rich repeat 418..486 CDD:275380 19/97 (20%)
leucine-rich repeat 441..464 CDD:275378 5/22 (23%)
LRR_8 487..545 CDD:290566 20/57 (35%)
leucine-rich repeat 487..510 CDD:275380 8/22 (36%)
leucine-rich repeat 511..534 CDD:275380 8/22 (36%)
LRR_8 533..589 CDD:290566 11/58 (19%)
leucine-rich repeat 535..558 CDD:275380 5/22 (23%)
leucine-rich repeat 559..580 CDD:275380 6/23 (26%)
7tm_4 764..>892 CDD:304433 26/132 (20%)
7tm_1 770..1017 CDD:278431 39/257 (15%)
Phlpp2NP_001102601.2 RA_PHLPP2 66..178 CDD:340761 17/79 (22%)
PH_PHLPP-like 185..279 CDD:270131 13/95 (14%)
PLN00113 284..>762 CDD:215061 135/538 (25%)
leucine-rich repeat 289..309 CDD:275380 6/21 (29%)
leucine-rich repeat 310..336 CDD:275380 5/26 (19%)
leucine-rich repeat 337..359 CDD:275380 6/22 (27%)
leucine-rich repeat 360..382 CDD:275380 8/22 (36%)
leucine-rich repeat 383..405 CDD:275380 11/22 (50%)
leucine-rich repeat 406..428 CDD:275380 6/21 (29%)
leucine-rich repeat 429..452 CDD:275380 9/23 (39%)
leucine-rich repeat 453..476 CDD:275380 3/22 (14%)
leucine-rich repeat 477..497 CDD:275380 2/19 (11%)
leucine-rich repeat 498..517 CDD:275380 6/18 (33%)
leucine-rich repeat 518..539 CDD:275380 6/20 (30%)
leucine-rich repeat 540..562 CDD:275380 6/21 (29%)
leucine-rich repeat 563..584 CDD:275380 12/34 (35%)
leucine-rich repeat 586..607 CDD:275380 6/21 (29%)
leucine-rich repeat 608..631 CDD:275380 5/22 (23%)
leucine-rich repeat 632..681 CDD:275380 8/50 (16%)
leucine-rich repeat 682..705 CDD:275380 8/22 (36%)
leucine-rich repeat 706..728 CDD:275380 8/22 (36%)
leucine-rich repeat 751..772 CDD:275380 4/20 (20%)
PP2Cc 820..1069 CDD:238083 65/409 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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