DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Tlr11

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001138251.2	Gene:	Tlr11 / 498491	RGDID:	1564460	Length:	932	Species:	Rattus norvegicus

Alignment Length:	1053	Identity:	222/1053 - (21%)
Similarity:	359/1053 - (34%)	Gaps:	322/1053 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 NNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQ 252
            |..|.|:..|:        |:......:..:..|||.|...|:.|.|| .|..::..::||||.|
  Rat    78 NQTLEKVPRNT--------EVLCLQGMVPTLPANAFDGFYSLQLLRLQ-LGTTNITSRTFQGLDQ 133

  Fly   253 LTSLQLNGNA----LVSLDGDCLGHLQKLRTLRLEGN-LFYR----IPTNALAGLRTLEALNLGS 308
            |..|....:|    .:.|..|.|..|:.|.:|..:|. |.|.    :||       ||..|.:.:
  Rat   134 LQYLFFEHHAPCCLSLFLPPDSLESLRSLSSLSFQGYCLTYSHSIYLPT-------TLRHLTMRN 191

  Fly   309 NLLTIIND----------------EDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKV--LELD 355
            :.||.:.:                ...||.|.|.||.|..|  :::....:::|..|.:  |.||
  Rat   192 SCLTKLQELQRLFPDLLLGASSTPNTKPRTPFLEVLDLSYN--LQLKQAGIRDLYGLTLHSLILD 254

  Fly   356 DNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRK 420
            ...:.:|....|.|..|..||:....:.     :||.|:                  .|.|:|..
  Rat   255 GTPLRALDLTSSGLLHLHFLSLVGTGIE-----KLPASV------------------TGFSELCA 296

  Fly   421 LIL--SDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSS 483
            |.|  :.::.:....::....||:.|.|....:|.:|....|..|:|:.|.|..|.|..|..|..
  Rat   297 LDLGKNQIQNILGNGDILGLKALKFLSLHDNHLQSLPVRFLRTLPQLQKLNLSMNKLGPILELPE 361

  Fly   484 ---CRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEI 545
               ..:|.:||||.||:.:|....|:.|.||.:|.||.|.|.:|..::.||:..|:.|||..|:|
  Rat   362 GLFSTNLTVLDLSHNQLCEIPRGNFSFLSQLQELWLSGNNISSLSNESLQGLRWLRTLDLSWNQI 426

  Fly   546 SYIHKEAFSGFTALEDLNLGNNIFPELPES---GLRALLHLKTFNNPKLREFPPPDTFPRIQTLI 607
            ..:.....|...||..|||.......:..:   |.:.|.||      :|..||..:.:.....::
  Rat   427 KVLKPGWLSHLPALTTLNLLGTYLEHISGTQLQGPKMLRHL------QLGSFPTLEIYRLWFPML 485

  Fly   608 LSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMH 672
            ||.......::..:..|.        |..||                     :.||:.:....:.
  Rat   486 LSLEIQAETYIQFMVPSG--------EPFLF---------------------LENLTLETSNLLL 521

  Fly   673 DPWETAINFNEEQLQTQTGGQI--ATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSV 735
            :|..|.|:|...:..|..|..|  :||.::.:|.
  Rat   522 EPKTTTIHFPSLRRLTLRGYSIFLSTSQLQSFFP------------------------------- 555

  Fly   736 QCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADF 800
                   |.||..:.|..|   |           .|...|.:.|     .::||..|..|...:|
  Rat   556 -------PQLPLLEYFFVW---C-----------RNDDAVDLHL-----FEMPRLRVLELGNLNF 594

  Fly   801 FMGIYLGILAIVDAATLG-EFRMFAIPWQMSVLC---------QLSGFLAVLSSELSVYTLAVIT 855
            |          .:::|:. |..:..:| |:.||.         .:|.|..:.|.:     |.::.
  Rat   595 F----------YESSTVKLEMLLNEVP-QLQVLALSHLNLKNLSVSSFKGLQSLK-----LLLLN 643

  Fly   856 LERNYAITHAIHLNKRL-----SLKQAGYIMSV------------GW--------VFALIMALMP 895
            .||      |:.:|..|     .:.|..|...|            .|        |:.|...:.
  Rat   644 SER------ALEMNSNLQELIPQIPQYVYFSDVTFACQCETSWLESWATRAPNTFVYGLEKPIC- 701

  Fly   896 LVGVSDYRKFAVCLPFETTTGPASLTY-----VISLMFINGCAFLTLMGC----YLKMYWAIRGS 951
            :...|||.| .:...|..|..|....:     ..||:.:  ...|.|:.|    :|...|.:..:
  Rat   702 MANASDYSK-TLLFSFLATNCPHGTEFWGFLTSFSLLLL--LIILPLISCHKWSWLHHLWTLFHT 763

  Fly   952 QAWNTNDSRIAKRMALLVFTDFLC-----WSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSC 1011
            ..|.....|:..:....||..: |     |                 .||:       ::|:...
  Rat   764 CWWKLGGHRLRGQFNYDVFISY-CEEDQDW-----------------VLEE-------LVPVLEK 803

  Fly  1012 CNPFLYAIMTKQFKKDCVTLCKHFEESRVVGGGGPGGRGAVARTKRGDLPPPLLPAAAVAHP--- 1073
            ..|          :.:.:.||.   .:|..|.|.......:|...:......:|...|:|.|
  Rat   804 APP----------EGEGLRLCL---PARDFGIGNDRMESMIASMGKSRAILCVLTGQALASPWCN 855

  Fly  1074 -------------PGCRCLRML------PSEMPNWHKMEQTPSMW-------------QRLRTFC 1106
                         ||..||.:|      ..::.::|::    |.|             ....|||
  Rat   856 LELRLATYHLIARPGTTCLLLLFLEPLDRQKLHSYHRL----SRWLQKEDYFDLSQGKMEWNTFC 916

  Fly  1107 CGENRRRRKQRRQ 1119
            ....:|.||.|::
  Rat   917 EQLKQRLRKARKE 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	57/221 (26%)
		leucine-rich repeat	183..204	CDD:275380	4/15 (27%)
		LRR_8	203..263	CDD:290566	18/63 (29%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	18/67 (27%)
		leucine-rich repeat	253..276	CDD:275380	7/26 (27%)
		leucine-rich repeat	277..300	CDD:275380	7/27 (26%)
		LRR_8	299..359	CDD:290566	18/77 (23%)
		leucine-rich repeat	301..324	CDD:275380	6/38 (16%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	70/246 (28%)
		leucine-rich repeat	349..371	CDD:275380	7/23 (30%)
		LRR_8	370..425	CDD:290566	11/56 (20%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		leucine-rich repeat	394..415	CDD:275380	0/20 (0%)
		leucine-rich repeat	418..486	CDD:275380	18/72 (25%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	25/57 (44%)
		leucine-rich repeat	487..510	CDD:275380	10/22 (45%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	16/58 (28%)
		leucine-rich repeat	535..558	CDD:275380	7/22 (32%)
		leucine-rich repeat	559..580	CDD:275380	5/23 (22%)
		7tm_4	764..>892	CDD:304433	30/162 (19%)
		7tm_1	770..1017	CDD:278431	54/295 (18%)
Tlr11	NP_001138251.2	leucine-rich repeat	111..133	CDD:275380	9/22 (41%)
		LRR_RI	<179..427	CDD:238064	74/279 (27%)
		leucine-rich repeat	224..246	CDD:275380	6/23 (26%)
		leucine-rich repeat	248..270	CDD:275380	6/21 (29%)
		LRR_8	270..329	CDD:290566	15/81 (19%)
		leucine-rich repeat	271..293	CDD:275380	7/44 (16%)
		leucine-rich repeat	294..318	CDD:275380	3/23 (13%)
		LRR_8	319..378	CDD:290566	20/58 (34%)
		leucine-rich repeat	319..342	CDD:275380	6/22 (27%)
		leucine-rich repeat	343..367	CDD:275380	7/23 (30%)
		LRR_8	366..426	CDD:290566	25/59 (42%)
		leucine-rich repeat	368..391	CDD:275380	10/22 (45%)
		leucine-rich repeat	392..415	CDD:275380	9/22 (41%)
		LRR_8	416..471	CDD:290566	17/60 (28%)
		leucine-rich repeat	416..437	CDD:275380	7/20 (35%)
		leucine-rich repeat	440..463	CDD:275380	5/22 (23%)
		leucine-rich repeat	533..583	CDD:275380	15/106 (14%)
		leucine-rich repeat	584..612	CDD:275380	7/38 (18%)
		leucine-rich repeat	613..633	CDD:275380	4/19 (21%)
		TIR_2	781..>861	CDD:290400	18/117 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910