DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lgr6

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_573455.1	Gene:	Lgr6 / 498233	RGDID:	1560339	Length:	965	Species:	Rattus norvegicus

Alignment Length:	973	Identity:	297/973 - (30%)
Similarity:	441/973 - (45%)	Gaps:	170/973 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |||.....:|...|..:|:..||.:|......|||..||||:|:...|.....||||.||.|.:.
  Rat    39 CHCQEDGIMLSADCSELGLSEVPADLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS 103

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSL------DGDCLGHLQ 275
            ::...||.||..||.|.||:..|:.:|.::...|..|.||:|:.| |:||      :|     |.
  Rat   104 HIPRQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDAN-LISLVPERSFEG-----LS 162

  Fly   276 KLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISA 340
            .||.|.|:.|....||..||..|..|:|:.|..|.:..|.|..|..:.:|:||.|..|:|..:..
  Rat   163 SLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRIRHIPDYAFQNLTSLVVLHLHNNRIQHVGT 227

  Fly   341 GALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRS--MQMLDMRANP 403
            .:.:.|..|:.|:|:.|.:...|..:..|.:||||...:|.::.|.:.....:  :|.:....||
  Rat   228 HSFEGLHNLETLDLNYNELQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNP 292

  Fly   404 LSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSL 468
            :..:...||:.:|||..|.|:....::.||:|:...:||||.|.||||:.:||.:|:|.|||:.|
  Rat   293 IQFVGRSAFQYLSKLHTLSLNGATDIQEFPDLKGTTSLEILTLTRAGIRLLPAGMCQQLPRLRIL 357

  Fly   469 ELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIP 533
            ||..|.::.:|:|..|                        ::|.::.|.:|||..:..|.|..:.
  Rat   358 ELSHNQIEELPSLHRC------------------------QKLEEIGLQHNRIWEIGADTFSQLS 398

  Fly   534 KLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPD 598
            .||.|||..|.|..||.||||...:|..|:|.:|....||.:||..|:|||...|..|.:....|
  Rat   399 SLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKD 463

  Fly   599 TFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNL 663
            :||:::.|.:.|||.|||:
  Rat   464 SFPKLRILEVPYAYQCCAY---------------------------------------------- 482

  Fly   664 SKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSG---- 724
                        ....||      .:|.||    :..|.|...:...|....|...|....
  Rat   483 ------------GLCANF------FKTSGQ----WQAEDFHAEEEEAPKRPLGLLAGQAENHYDL 525

  Fly   725 ------MSTEDFQP-GSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLC-S 781
                  |.|||.:| .||||.|:||||.||..||:.|.:|..||.:.|||:|.||.|:..:.. .
  Rat   526 DLDELQMETEDSKPHPSVQCSPVPGPFKPCEHLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGG 590

  Fly   782 RSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSEL 846
            .|.:...:.:|..:|.|:...||..|:||.|||.|.|:|..:...|:..:.||.:||||||.||.
  Rat   591 PSPLSPVKLVVGAIAGANALTGISCGLLASVDALTFGQFAEYGARWETGLGCQATGFLAVLGSEA 655

  Fly   847 SVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWV---------FALIMALMPLVGVSDY 902
            ||..|.:..::.:.::|         .::..|...|.|.|         .|.:.|.:||..|.:|
  Rat   656 SVLLLTLAAVQCSVSVT---------CVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEY 711

  Fly   903 RKFAVCLPFETTTG-PASLTYVISLMFINGCAFLTLMGCYLKMYWAI-RG--SQAWNTNDSRIAK 963
            ....:|||:....| ||:|.:.::|:.:|...||.:.|.|:|:|..: ||  ...|   |..:.:
  Rat   712 GASPLCLPYAPPEGRPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVW---DCAMVR 773

  Fly   964 RMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDC 1028
            .:|.|:|.|.|.:.|:||.|..::.||..::.|..|...:.||||.:|.||.||.:....|::|.
  Rat   774 HVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFREDL 838

  Fly  1029 VTLCKHFEESRVVGGGGPGGRGAVARTKRGDLPPP----------------LLPAAAVAHPPG 1075
            ..|..           .|...|.:|.|..|:|...                :|.|:....|||
  Rat   839 RRLWP-----------SPRSPGPLAYTAAGELEKSSCDSTQALVAFSDVDLILEASEAGQPPG 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	73/208 (35%)
		leucine-rich repeat	183..204	CDD:275380	9/20 (45%)
		LRR_8	203..263	CDD:290566	24/59 (41%)
		leucine-rich repeat	205..228	CDD:275380	11/22 (50%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	24/64 (38%)
		leucine-rich repeat	253..276	CDD:275380	10/28 (36%)
		leucine-rich repeat	277..300	CDD:275380	10/22 (45%)
		LRR_8	299..359	CDD:290566	18/59 (31%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	77/241 (32%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	16/56 (29%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	29/67 (43%)
		leucine-rich repeat	441..464	CDD:275378	13/22 (59%)
		LRR_8	487..545	CDD:290566	13/57 (23%)
		leucine-rich repeat	487..510	CDD:275380	0/22 (0%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	25/55 (45%)
		leucine-rich repeat	535..558	CDD:275380	13/22 (59%)
		leucine-rich repeat	559..580	CDD:275380	8/20 (40%)
		7tm_4	764..>892	CDD:304433	42/137 (31%)
		7tm_1	770..1017	CDD:278431	82/260 (32%)
Lgr6	XP_573455.1	LRRNT	34..68	CDD:214470	9/28 (32%)
		LRR_RI	<70..248	CDD:238064	66/183 (36%)
		leucine-rich repeat	70..91	CDD:275380	9/20 (45%)
		LRR_8	92..150	CDD:290566	24/58 (41%)
		leucine-rich repeat	92..115	CDD:275380	11/22 (50%)
		leucine-rich repeat	116..139	CDD:275380	8/22 (36%)
		LRR_8	138..198	CDD:290566	24/65 (37%)
		leucine-rich repeat	140..163	CDD:275380	10/28 (36%)
		leucine-rich repeat	164..187	CDD:275380	10/22 (45%)
		LRR_8	186..246	CDD:290566	18/59 (31%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	236..258	CDD:275380	6/21 (29%)
		LRR_RI	253..>442	CDD:238064	69/212 (33%)
		LRR_8	258..314	CDD:290566	16/55 (29%)
		leucine-rich repeat	259..282	CDD:275380	6/22 (27%)
		leucine-rich repeat	283..304	CDD:275380	5/20 (25%)
		LRR_8	305..364	CDD:290566	28/58 (48%)
		leucine-rich repeat	330..344	CDD:275378	9/13 (69%)
		leucine-rich repeat	354..375	CDD:275380	8/44 (18%)
		LRR_8	375..434	CDD:290566	24/58 (41%)
		leucine-rich repeat	376..399	CDD:275380	7/22 (32%)
		leucine-rich repeat	400..421	CDD:275380	13/20 (65%)
		leucine-rich repeat	424..444	CDD:275380	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10347
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	380	1.000	Inparanoid score	I1993
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171884at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45552
orthoMCL	1	0.900	-	-		OOG6_106088
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2481
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.730