DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and lrrc40

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001011310.1	Gene:	lrrc40 / 496765	XenbaseID:	XB-GENE-968689	Length:	605	Species:	Xenopus tropicalis

Alignment Length:	634	Identity:	156/634 - (24%)
Similarity:	263/634 - (41%)	Gaps:	144/634 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 APD----MQNSQEQEPYVHLQH-LQQQQQQNPQTVQQLSQITVNRTSKSASVTPTGI-RENVMLP 100
            |||    .:..:||||.|  .| |.:..:::.|         :|.:::..:..|..: |.||..|
Frog    10 APDPLSGFRAPKEQEPAV--PHGLIKAARKSGQ---------LNLSARGLTDVPVSVWRINVDTP 63

  Fly   101 SADPEKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWLQKHCHCTGSLEVLRLSC 165
               ||....:       ::.||                      :||.::     ..|..|.|:.
Frog    64 ---PEAHQNV-------DFGGS----------------------DRWWEQ-----TDLTKLILAS 91

  Fly   166 RGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLK 230
            ..:.:|:..::|...:||||:.:|.:..|.. :.....||::|.:|.|.|..: |.....|..||
Frog    92 NKLQLLSEDISLLPALVVLDIHDNQIVSLPC-AIKELTNLQKLNISHNKIKQL-PKELQHLQNLK 154

  Fly   231 RLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDC----------------------LGH 273
            .|.||:..|:.| |.|...|:.|..|.::.|.|.|:....                      :|.
Frog   155 SLLLQHNQLEEL-PDSIGHLSILEELDVSNNCLRSISSSVGQLTGLVKFNLSSNKLTALPTEIGK 218

  Fly   274 LQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKI 338
            ::.|:.|....||...:|. ::||:.:||.|.|..|.||.:  .:.|.:..|..|.:..|||..:
Frog   219 MKNLKQLDCTSNLLENVPA-SVAGMESLEQLYLRQNKLTYL--PELPFLTKLKELHVGNNQIQTL 280

  Fly   339 SAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDT--ELPRSMQMLDMRA 401
            ....|:||::|.||||..|.:..|||.:|.|:.|:.|.:::|.|..:..|  .|| :::.|.:..
Frog   281 GPEHLQNLSSLSVLELRYNKLKVLPEEISLLNGLERLDLSNNDLGSLPCTLGSLP-NLKSLQLEG 344

  Fly   402 NPLSTISPGAF-RGMSKLRKLI-----LSDVRT-----------------------LRSFPELEA 437
            |||..|..... :|..:|.|.:     :.||:|                       :.:...||.
Frog   345 NPLRGIRRDILNKGTQELLKYLKGRVQVPDVKTQEDENSTATAMTLPSESVVNTHAIVTLKTLEY 409

  Fly   438 CHA-----------------LEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCR 485
            |..                 :..:...:..:.||||.:......:..:.|..|.:..| :|:.|.
Frog   410 CEKQASLIPEAVFNATGSSFITTVNFSKNQLTEVPARIVEMKDSVCDVNLGFNKISSI-SLNLCM 473

  Fly   486 DLRL--LDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYI 548
            .|:|  :|:.:|.:..:..: ...:.:|..::||:||.|..| |....||.|:.:.:..|:|..|
Frog   474 LLKLTHIDMRNNVLTSLPSE-MEAMTRLQSVILSFNRFKHFP-DVLYRIPTLETILISSNQIGSI 536

  Fly   549 HKEAFSGFTALEDLNLGNNIFPELPES-----GLRALLHLK--TFNNPK 590
            ........|.|..|:|.||...::|.:     .||| |||:  .|.||:
Frog   537 DPTQLIKMTKLSTLDLQNNDLLQIPPALGNCESLRA-LHLEGNPFRNPR 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/20 (25%)
		LRR_RI	180..>383	CDD:238064	67/224 (30%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	21/59 (36%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	10/22 (45%)
		LRR_8	252..311	CDD:290566	18/80 (23%)
		leucine-rich repeat	253..276	CDD:275380	6/44 (14%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	22/59 (37%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	70/289 (24%)
		leucine-rich repeat	349..371	CDD:275380	11/21 (52%)
		LRR_8	370..425	CDD:290566	15/62 (24%)
		leucine-rich repeat	372..393	CDD:275380	7/22 (32%)
		leucine-rich repeat	394..415	CDD:275380	5/21 (24%)
		leucine-rich repeat	418..486	CDD:275380	17/112 (15%)
		leucine-rich repeat	441..464	CDD:275378	4/22 (18%)
		LRR_8	487..545	CDD:290566	16/59 (27%)
		leucine-rich repeat	487..510	CDD:275380	4/24 (17%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	19/62 (31%)
		leucine-rich repeat	535..558	CDD:275380	4/22 (18%)
		leucine-rich repeat	559..580	CDD:275380	8/25 (32%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrrc40	NP_001011310.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		6/15 (40%)
		LRR	<82..348	CDD:227223	79/272 (29%)
		LRR 1	83..104		4/20 (20%)
		leucine-rich repeat	84..106	CDD:275380	5/21 (24%)
		LRR 2	106..127		6/21 (29%)
		leucine-rich repeat	107..129	CDD:275380	6/22 (27%)
		LRR 3	129..151		7/22 (32%)
		leucine-rich repeat	130..152	CDD:275380	7/22 (32%)
		LRR 4	152..173		9/21 (43%)
		leucine-rich repeat	153..175	CDD:275380	10/22 (45%)
		LRR 5	175..196		5/20 (25%)
		leucine-rich repeat	176..198	CDD:275380	5/21 (24%)
		LRR 6	198..219		1/20 (5%)
		leucine-rich repeat	199..221	CDD:275380	1/21 (5%)
		LRR 7	221..242		6/21 (29%)
		leucine-rich repeat	222..244	CDD:275380	7/22 (32%)
		internalin_A	238..>583	CDD:380193	91/351 (26%)
		LRR 8	244..265		8/22 (36%)
		leucine-rich repeat	245..266	CDD:275380	8/22 (36%)
		LRR 9	266..287		6/20 (30%)
		leucine-rich repeat	267..290	CDD:275380	8/22 (36%)
		LRR 10	290..311		10/20 (50%)
		leucine-rich repeat	291..313	CDD:275380	11/21 (52%)
		LRR 11	313..335		5/21 (24%)
		leucine-rich repeat	314..336	CDD:275380	7/22 (32%)
		LRR 12	336..357		5/20 (25%)
		leucine-rich repeat	337..355	CDD:275380	5/17 (29%)
		leucine-rich repeat	363..476	CDD:275380	16/113 (14%)
		LRR 13	429..450		4/20 (20%)
		LRR 14	453..475		5/22 (23%)
		LRR 15	476..497		3/21 (14%)
		leucine-rich repeat	477..522	CDD:275380	12/46 (26%)
		LRR 16	499..520		8/21 (38%)
		leucine-rich repeat	500..513	CDD:275380	6/12 (50%)
		LRR 17	522..543		4/20 (20%)
		leucine-rich repeat	523..546	CDD:275380	4/22 (18%)
		LRR 18	546..567		6/20 (30%)
		leucine-rich repeat	547..569	CDD:275380	6/21 (29%)
		LRR 19	569..590		9/17 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910