DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and AgaP_AGAP008170

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_001237909.2	Gene:	AgaP_AGAP008170 / 4577934	VectorBaseID:	AGAP008170	Length:	387	Species:	Anopheles gambiae

Alignment Length:	339	Identity:	84/339 - (24%)
Similarity:	139/339 - (41%)	Gaps:	94/339 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 NLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMD-----------PNAFY----- 224
            ::||..|:|.|.|     |:.|:|    ||:.:.....|.|.::           |.|.:
Mosquito    20 HIPNNTVLLKLVN-----LKTNTF----NLDTIDFVKTSGIGVEIERSSVKKVVMPAAGHIIRLV 75

  Fly   225 -------------GLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQK 276
                         |..:|..|.:.:..|||: |.:...||.|.:::::.:::.:::.:..|.|..
Mosquito    76 LVRTYLSDIVFDEGNERLSSLIISDSRLKSI-PSTITHLAALGTVEISKSSIETVNMNLFGKLTH 139

  Fly   277 LRTLRLEGNLFYRIPTNALAG--LRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKI- 338
            ||.|.|..|....:..:..||  ...|..|.|..|.||.||...|..||:|..|.|:.|:|.::
Mosquito   140 LRYLNLCDNKILSLHLSGAAGADFAQLSDLFLSGNQLTAINLSGFNGMPSLETLDLQNNRIRRVQ 204

  Fly   339 ---SAGALK-----------------NLTALKVLELDDNLISSLPEGLS---------------- 367
               .:..||                 ||.:|..|.|..|.:|.||..||
Mosquito   205 GTLESNTLKTLDLSWNRIDVLYCCEWNLPSLVRLTLSRNELSRLPTCLSLVMPNVTYLLLDSNAL 269

  Fly   368 ----------KLSQLQELSITSNRL-RWINDTELPRSMQMLDMRANPLSTIS-PGAFRGM---SK 417
                      .|..||:|.|:.||| |.:.|| |.:|:.:|:::.|.:..:| |.|.:.:   :.
Mosquito   270 TDGDSWYSILTLEGLQQLDISHNRLTRAVFDT-LSQSLHILNLQNNNIKVLSVPVAGKRLKINAS 333

  Fly   418 LRKLILSDVRTLRS 431
            ...:...|:::|.|
Mosquito   334 FNSIDTFDIKSLSS 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	0/2 (0%)
		LRR_RI	180..>383	CDD:238064	69/281 (25%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	16/88 (18%)
		leucine-rich repeat	205..228	CDD:275380	6/51 (12%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	14/60 (23%)
		leucine-rich repeat	253..276	CDD:275380	3/22 (14%)
		leucine-rich repeat	277..300	CDD:275380	7/24 (29%)
		LRR_8	299..359	CDD:290566	24/80 (30%)
		leucine-rich repeat	301..324	CDD:275380	10/22 (45%)
		leucine-rich repeat	325..348	CDD:275380	9/43 (21%)
		LRR_RI	327..567	CDD:238064	38/157 (24%)
		leucine-rich repeat	349..371	CDD:275380	10/47 (21%)
		LRR_8	370..425	CDD:290566	17/59 (29%)
		leucine-rich repeat	372..393	CDD:275380	11/21 (52%)
		leucine-rich repeat	394..415	CDD:275380	5/21 (24%)
		leucine-rich repeat	418..486	CDD:275380	3/14 (21%)
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP008170	XP_001237909.2	LRR_8	92..150	CDD:290566	16/58 (28%)
		leucine-rich repeat	93..115	CDD:275380	7/22 (32%)
		leucine-rich repeat	116..139	CDD:275380	3/22 (14%)
		LRR_8	138..200	CDD:290566	22/61 (36%)
		LRR_RI	140..321	CDD:238064	51/181 (28%)
		leucine-rich repeat	140..165	CDD:275380	7/24 (29%)
		leucine-rich repeat	166..189	CDD:275380	10/22 (45%)
		LRR_8	188..245	CDD:290566	14/56 (25%)
		leucine-rich repeat	190..234	CDD:275380	9/43 (21%)
		LRR_8	233..294	CDD:290566	15/60 (25%)
		leucine-rich repeat	235..258	CDD:275380	9/22 (41%)
		leucine-rich repeat	259..283	CDD:275380	1/23 (4%)
		leucine-rich repeat	284..305	CDD:275380	11/21 (52%)
		leucine-rich repeat	328..348	CDD:275378	3/20 (15%)
		leucine-rich repeat	349..361	CDD:275378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910