DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and AgaP_AGAP001127

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_001238574.2	Gene:	AgaP_AGAP001127 / 4577388	VectorBaseID:	AGAP001127	Length:	469	Species:	Anopheles gambiae

Alignment Length:	450	Identity:	111/450 - (24%)
Similarity:	189/450 - (42%)	Gaps:	63/450 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 HCTGSL--------EVLRLSCRGIGILAVPVN-----------LPNE-----VVVLDLGNNNLTK 193
            ||..||        .::||:|..:....:..|           :.||     :...|...:.|..
Mosquito    11 HCVASLFLLTVANGAIIRLNCDTVDDKCLLKNVFASEDDRFKEIRNERYQSIIEFFDCHIHTLPP 75

  Fly   194 LEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQL 258
            :        |.:.::..:..:::.::.|.|   :.:.||.:....|:.:..::|:...:|..|.|
Mosquito    76 I--------PYINKVKANAINLVRIEENTF---STIHRLDVSYNRLREISTKAFEYPEELLELNL 129

  Fly   259 NGNALVSLDGDCLGHLQKLRTL-----RLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDED 318
            |||..:. |...|..|..||:|     :||..|   :..|:.||:..|..||:..|.:|.|....
Mosquito   130 NGNPTLK-DFAFLSKLTGLRSLDMADMKLELEL---LDINSFAGMSELSTLNMSDNRITSIPVGM 190

  Fly   319 FPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLR 383
            |..:..|..|.|.||.|.||::|.....|.          .|.|.:|:  ..|.....::||.:.
Mosquito   191 FSPLVGLTDLDLSRNYITKIASGTFAIATT----------HSYLRDGI--YHQALNFDLSSNNVS 243

  Fly   384 WINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDR 448
            .|.:.....:.: :::|.|.|..|...||...:.|..|.||....|::|..|....||..|.:..
Mosquito   244 IIENNAFLHASK-VNLRNNKLIGIGQYAFDNQTALEHLDLSGNDQLKNFDFLHNLRALHYLDMSH 307

  Fly   449 A--GIQEVPANLCRQTPRLKSLELKTNSLKRIP--NLSSCRDLRLLDLSSNQIEKIQGKPFNGLK 509
            .  ....||.|:......|.:|:|..|.:..||  ..:..:.|..::|..|.|..|:...|:..|
Mosquito   308 MNFSFDGVPRNIFDDLDSLTTLDLSNNRILEIPIGIFAELQSLNFINLRHNSISHIEFGTFSMRK 372

  Fly   510 Q--LNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNN 567
            .  ::::.||||.||.|....|..:..|:.|.|.||:|||::.:..:...:|.:..:.|:
Mosquito   373 YDLIDEIDLSYNNIKELNFLVFVPLKYLKTLLLHGNKISYVNAKQLTRNKSLYNFGIQNS 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/39 (13%)
		LRR_RI	180..>383	CDD:238064	51/212 (24%)
		leucine-rich repeat	183..204	CDD:275380	2/20 (10%)
		LRR_8	203..263	CDD:290566	13/59 (22%)
		leucine-rich repeat	205..228	CDD:275380	2/22 (9%)
		leucine-rich repeat	229..252	CDD:275380	4/22 (18%)
		LRR_8	252..311	CDD:290566	22/63 (35%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	9/27 (33%)
		LRR_8	299..359	CDD:290566	17/59 (29%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	9/22 (41%)
		LRR_RI	327..567	CDD:238064	65/245 (27%)
		leucine-rich repeat	349..371	CDD:275380	3/21 (14%)
		LRR_8	370..425	CDD:290566	13/54 (24%)
		leucine-rich repeat	372..393	CDD:275380	3/20 (15%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	19/71 (27%)
		leucine-rich repeat	441..464	CDD:275378	5/24 (21%)
		LRR_8	487..545	CDD:290566	20/59 (34%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	10/34 (29%)
		leucine-rich repeat	535..558	CDD:275380	8/22 (36%)
		leucine-rich repeat	559..580	CDD:275380	2/8 (25%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP001127	XP_001238574.2	leucine-rich repeat	101..123	CDD:275380	4/21 (19%)
		leucine-rich repeat	124..172	CDD:275380	18/51 (35%)
		LRR_8	145..207	CDD:290566	21/64 (33%)
		LRR_RI	171..412	CDD:238064	70/253 (28%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		leucine-rich repeat	197..220	CDD:275380	9/22 (41%)
		leucine-rich repeat	221..255	CDD:275380	7/35 (20%)
		LRR_8	252..336	CDD:290566	23/84 (27%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		leucine-rich repeat	277..299	CDD:275380	7/21 (33%)
		leucine-rich repeat	300..325	CDD:275380	5/24 (21%)
		LRR_8	325..386	CDD:290566	17/60 (28%)
		leucine-rich repeat	326..349	CDD:275380	6/22 (27%)
		leucine-rich repeat	350..369	CDD:275380	5/18 (28%)
		leucine-rich repeat	376..399	CDD:275380	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910