DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and AgaP_AGAP005668

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_001237694.1	Gene:	AgaP_AGAP005668 / 4576765	VectorBaseID:	AGAP005668	Length:	405	Species:	Anopheles gambiae

Alignment Length:	383	Identity:	91/383 - (23%)
Similarity:	165/383 - (43%)	Gaps:	86/383 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 LDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKL 418
            :|..|:..||..:..| .:|.    :..|:||:   :|::::.|.:....|..|.   |...|.|
Mosquito    64 MDLPLLKDLPSFVKSL-YIQH----ATPLKWIS---VPQTLKALSIELTRLRRIE---FEANSTL 117

  Fly   419 RKLILSDVRTLRSFPE-LEACHALEILKLDRAGIQEVP-ANLCRQTPRLKSLELKTNSLKRIPNL 481
            :.|:::..: |.:.|: ::....|..|::....||::. |:|| :...|.::.|..|.|:.|.|.
Mosquito   118 KHLMIAYCQ-LSTLPDAIQHAPMLLHLQITSCNIQQLDMASLC-ENALLSTVILTRNKLRYIANT 180

  Fly   482 SS--CR---DLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALP-QDAFQGIPKLQLLDL 540
            |:  |.   .|..|.|:.|:::.|..:.|||..:|:.:.|..|||.:|. :.....|.:|: :|:
Mosquito   181 STKQCALYDSLSALVLTGNRLKSINMELFNGFVRLDSVFLQSNRITSLAGRFVHNAIAELR-MDI 244

  Fly   541 EGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQT 605
              |.::::....:| ..||..|:...|:..|:|          |..||.|           .|..
Mosquito   245 --NRLAWVDLCQWS-VPALVWLSFDENVLAEVP----------KCMNNLK-----------NITR 285

  Fly   606 LILS------YAYHCCA---FLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSM----MNIW 657
            |:||      :.....|   .|..:::|..:..|....:..||...|| :.|::|::    ::..
Mosquito   286 LVLSSNVLSNFTIESVAGMEHLVSLSLSYNQLLSVTLNSERFPRRLEF-INLYHNNLTSLDLSFI 349

  Fly   658 P----------------QMHNLSKQLG--ASMHDP----WETAINFNEEQLQ--TQTG 691
            |                .:|..|..:.  |..|:|    |:  |:...||:|  .|||
Mosquito   350 PVRSLKIDASRNFIASFDVHGTSANVSRLAMEHNPIDCSWD--IDTKREQMQCKIQTG 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	6/28 (21%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566	1/4 (25%)
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064	56/220 (25%)
		leucine-rich repeat	349..371	CDD:275380	5/16 (31%)
		LRR_8	370..425	CDD:290566	12/54 (22%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	19/74 (26%)
		leucine-rich repeat	441..464	CDD:275378	7/23 (30%)
		LRR_8	487..545	CDD:290566	18/58 (31%)
		leucine-rich repeat	487..510	CDD:275380	8/22 (36%)
		leucine-rich repeat	511..534	CDD:275380	7/23 (30%)
		LRR_8	533..589	CDD:290566	12/55 (22%)
		leucine-rich repeat	535..558	CDD:275380	4/22 (18%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP005668	XP_001237694.1	leucine-rich repeat	117..139	CDD:275380	4/22 (18%)
		leucine-rich repeat	164..190	CDD:275380	8/25 (32%)
		LRR_8	190..247	CDD:290566	18/59 (31%)
		leucine-rich repeat	191..214	CDD:275380	8/22 (36%)
		leucine-rich repeat	215..259	CDD:275380	11/47 (23%)
		leucine-rich repeat	260..282	CDD:275380	9/42 (21%)
		LRR_8	281..341	CDD:290566	15/71 (21%)
		leucine-rich repeat	283..306	CDD:275380	5/22 (23%)
		leucine-rich repeat	307..330	CDD:275380	5/22 (23%)
		leucine-rich repeat	354..365	CDD:275378	0/10 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910