DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and AgaP_AGAP007461

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_001237077.2	Gene:	AgaP_AGAP007461 / 4576239	VectorBaseID:	AGAP007461	Length:	384	Species:	Anopheles gambiae

Alignment Length:	363	Identity:	86/363 - (23%)
Similarity:	153/363 - (42%)	Gaps:	88/363 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 FFM--APNLEELTLSDN---SIINMD-------PNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLA 251
            :|:  ||.|..:.|..|   |:::::       |.....:..|.||::::|.::.|....|..|.
Mosquito    53 YFLHKAPLLRYVYLQHNVNVSLLHIEHCSLTGMPRTIRNVPNLLRLAIKSCRIRHLDLNDFADLH 117

  Fly   252 QLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIIND 316
            .|.|:.|..|.:|                                   |:..|...|:|:..||.
Mosquito   118 SLYSVDLTNNRIV-----------------------------------TITELLPASDLVLPINR 147

  Fly   317 EDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNR 381
                       |.|..|.:.:::..||..||.|..|.|:.|.|..:...:: |.:|:|||:.:||
Mosquito   148 -----------LYLANNSLTQLNVRALGALTDLHCLVLEGNRIEEVNSPIA-LPKLEELSLRNNR 200

  Fly   382 LRWINDT--ELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEIL 444
            ::.:|.|  .|| :::.|....|.|| |:|..::.|.::..|.|| ...|.|| .::..:..::.
Mosquito   201 IKQLNCTGWHLP-ALKYLFCSGNRLS-IAPIEWQSMWRIEVLDLS-FNLLHSF-RMDDIYLTQLY 261

  Fly   445 KLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLK 509
            .|:.||.|.....    ||::..         |:|       |..|.|:.|::..:....:: :.
Mosquito   262 ALNLAGNQLTSVT----TPQMHF---------RVP-------LSRLWLAQNRLPVLDISRWD-MP 305

  Fly   510 QLNDLLLSYNRIKALPQDAFQGIPKL-QLLDLEGNEIS 546
            .|.:|.:::||:..| .|.|...|.| .::.|..|:.|
Mosquito   306 NLWELDVAHNRLTEL-ADVFVRFPNLAPMMILRNNQWS 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	45/195 (23%)
		leucine-rich repeat	183..204	CDD:275380	2/6 (33%)
		LRR_8	203..263	CDD:290566	17/69 (25%)
		leucine-rich repeat	205..228	CDD:275380	5/32 (16%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	8/58 (14%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	0/22 (0%)
		LRR_8	299..359	CDD:290566	17/59 (29%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	60/223 (27%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	19/56 (34%)
		leucine-rich repeat	372..393	CDD:275380	10/22 (45%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	14/67 (21%)
		leucine-rich repeat	441..464	CDD:275378	5/22 (23%)
		LRR_8	487..545	CDD:290566	15/58 (26%)
		leucine-rich repeat	487..510	CDD:275380	4/22 (18%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	5/15 (33%)
		leucine-rich repeat	535..558	CDD:275380	4/13 (31%)
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP007461	XP_001237077.2	LRR_8	71..129	CDD:290566	13/57 (23%)
		leucine-rich repeat	72..94	CDD:275380	2/21 (10%)
		LRR_RI	78..319	CDD:238064	71/312 (23%)
		leucine-rich repeat	95..118	CDD:275380	7/22 (32%)
		leucine-rich repeat	119..146	CDD:275380	9/61 (15%)
		LRR_8	147..201	CDD:290566	18/65 (28%)
		leucine-rich repeat	147..168	CDD:275380	6/31 (19%)
		LRR_4	169..205	CDD:289563	12/36 (33%)
		leucine-rich repeat	169..190	CDD:275380	6/21 (29%)
		LRR_8	189..247	CDD:290566	20/60 (33%)
		leucine-rich repeat	191..213	CDD:275380	10/22 (45%)
		leucine-rich repeat	214..236	CDD:275380	7/22 (32%)
		leucine-rich repeat	237..259	CDD:275380	6/23 (26%)
		leucine-rich repeat	307..329	CDD:275380	7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910