DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and tril

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_009292463.1	Gene:	tril / 448885	ZFINID:	ZDB-GENE-131218-1	Length:	758	Species:	Danio rerio

Alignment Length:	414	Identity:	105/414 - (25%)
Similarity:	168/414 - (40%)	Gaps:	92/414 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 SICERWLQKHCHCTGSLEVLRLSCRGIGILAVP----VNLPNEVVVLDLGNNNLTKLEANSFFMA 202
            :||    .:.|.|..:..:|   |...|:.|||    |....:|.||.|..|.:..:.|..|...
Zfish    24 AIC----PERCDCQHAQHIL---CANRGLRAVPKAPQVEHAEDVRVLSLAGNFIHNISAFDFMRY 81

  Fly   203 PNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLD 267
            .:|..|.|..|.|.::.|.:|..|:||:.|.|.|..:.::.|.:.|.|.:||.|..|.|.:
Zfish    82 GDLMRLNLQFNQIRSIHPESFKKLSKLEELFLGNNLISTIQPGTLQSLKKLTILYSNNNEI---- 142

  Fly   268 GDCL----GHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVL 328
            .:|:    .||..|..|||:|                        |.:.::.:..|..:|||:.|
Zfish   143 NECIPKSFTHLNSLVKLRLDG------------------------NSIEVLKESVFEGLPNLMFL 183

  Fly   329 LLKRNQIMKISAGALKNLTALKVLELDDNLISSLPE--GLSKLSQLQELSITSNRLRWIND--TE 389
            .|:.|.:.:|...|...|:.|:.|.|.||..:.|.:  ..|.|..|:.|.|..|::|.:.:  .:
Zfish   184 HLESNHLRRIDRNAFLRLSKLQFLNLSDNKQTELQDVFMFSDLKSLKTLLIAGNQIRHVGNHVFQ 248

  Fly   390 LPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEV 454
            ..:.:..|.:..|.:|.:...||:|:.::|:.:                       :||..:.|:
Zfish   249 SLKKLSKLSLSHNKISKLGNEAFKGLGRVREFM-----------------------IDRNELTEI 290

  Fly   455 PANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYN 519
            ||.|             .:.|:||.:         ||.|.|.|..:....|..|..|..|.|..|
Zfish   291 PAGL-------------LDPLERIEH---------LDFSDNHISLVDQGAFGHLSHLKILKLKNN 333

  Fly   520 RIKALPQDAFQGIPKLQLLDLEGN 543
            |:..|....|.....|..::|.||
Zfish   334 RLMNLSGSIFASNGGLFHVELNGN 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/24 (29%)
		LRR_RI	180..>383	CDD:238064	59/208 (28%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	21/59 (36%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	14/62 (23%)
		leucine-rich repeat	253..276	CDD:275380	8/26 (31%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		LRR_8	299..359	CDD:290566	16/59 (27%)
		leucine-rich repeat	301..324	CDD:275380	2/22 (9%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	53/221 (24%)
		leucine-rich repeat	349..371	CDD:275380	8/23 (35%)
		LRR_8	370..425	CDD:290566	12/56 (21%)
		leucine-rich repeat	372..393	CDD:275380	5/22 (23%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	10/67 (15%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	18/57 (32%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	4/11 (36%)
		leucine-rich repeat	535..558	CDD:275380	4/9 (44%)
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
tril	XP_009292463.1	LRRNT	25..56	CDD:214470	11/37 (30%)
		leucine-rich repeat	60..83	CDD:275380	7/22 (32%)
		LRR_8	84..142	CDD:290566	21/57 (37%)
		LRR_4	84..123	CDD:289563	13/38 (34%)
		leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		leucine-rich repeat	132..155	CDD:275380	8/26 (31%)
		LRR_8	155..213	CDD:290566	20/81 (25%)
		LRR_RI	156..>358	CDD:238064	63/271 (23%)
		leucine-rich repeat	156..179	CDD:275380	7/46 (15%)
		leucine-rich repeat	180..203	CDD:275380	7/22 (32%)
		leucine-rich repeat	204..228	CDD:275380	8/23 (35%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		LRR_8	259..311	CDD:290566	19/96 (20%)
		leucine-rich repeat	277..298	CDD:275380	7/56 (13%)
		LRR_8	300..358	CDD:290566	20/67 (30%)
		leucine-rich repeat	301..324	CDD:275380	8/31 (26%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		FN3	546..614	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910