DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and vasn

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001005036.1	Gene:	vasn / 448556	XenbaseID:	XB-GENE-941552	Length:	661	Species:	Xenopus tropicalis

Alignment Length:	326	Identity:	88/326 - (26%)
Similarity:	138/326 - (42%)	Gaps:	45/326 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 NLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLK 240
            |.|..|..|...|:|..:      .:.|:...|.:.:|.|.:::.::|.||..|..|.|.:..|.
Frog    29 NTPQTVFCLARKNSNFPR------SVPPDTLNLYVFENGISSIEESSFIGLNGLHLLDLSHNQLS 87

  Fly   241 SLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALN 305
            |||...|:.||.|::|.|..|.|..:..|....|.:|..|.|.||....|...|..|:.:|..|.
Frog    88 SLPGGVFRNLANLSNLDLTSNQLTEISADTFQGLSRLERLYLNGNRIRSIHPEAFKGIESLLELK 152

  Fly   306 LGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGA-----------------------LKNLT 347
            |.:|.|  :....| .:|:|::|.|..|.|..|..|.                       |..|.
Frog   153 LSNNQL--VTPPAF-SLPHLLLLDLSYNAIPVIQQGVFNAGNIESLRLAGLGLKEVPEELLSGLK 214

  Fly   348 ALKVLELDDNLISSLPEGLSKLSQLQELSITSN----RLRWINDTELPRSMQMLDMRANPLSTIS 408
            .|..|:|.||.:..:|.||..|:   :|:|..|    :::..:.:.|| ::|.||:....|.|:.
Frog   215 NLHELDLSDNQLDKVPPGLHGLT---KLNIAGNVGFSQIQVDDLSNLP-ALQELDLSGLSLQTLP 275

  Fly   409 PGAFRGMSKLRKLILSD-----VRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSL 468
            .|.||...:||.:.|:.     |.:|....|......:.:|:.|.......|.|..:...:|:..
Frog   276 KGLFRSSKRLRAVSLAQNPFNCVCSLGWLSEWMRVSGVVLLRPDETRCHFPPKNAGKTLRQLRDS 340

  Fly   469 E 469
            |
Frog   341 E 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	1/2 (50%)
		LRR_RI	180..>383	CDD:238064	64/229 (28%)
		leucine-rich repeat	183..204	CDD:275380	3/20 (15%)
		LRR_8	203..263	CDD:290566	21/59 (36%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	19/58 (33%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	21/82 (26%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	9/45 (20%)
		LRR_RI	327..567	CDD:238064	42/175 (24%)
		leucine-rich repeat	349..371	CDD:275380	9/21 (43%)
		LRR_8	370..425	CDD:290566	16/58 (28%)
		leucine-rich repeat	372..393	CDD:275380	5/24 (21%)
		leucine-rich repeat	394..415	CDD:275380	8/20 (40%)
		leucine-rich repeat	418..486	CDD:275380	12/57 (21%)
		leucine-rich repeat	441..464	CDD:275378	4/22 (18%)
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
vasn	NP_001005036.1	LRRNT	21..52	CDD:214470	7/28 (25%)
		leucine-rich repeat	52..75	CDD:275380	6/22 (27%)
		LRR 1	52..72		4/19 (21%)
		LRR	<60..>276	CDD:227223	65/222 (29%)
		LRR 2	75..96		8/20 (40%)
		leucine-rich repeat	76..99	CDD:275380	9/22 (41%)
		LRR_8	99..158	CDD:338972	19/58 (33%)
		LRR 3	99..120		6/20 (30%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		LRR 4	123..144		7/20 (35%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		LRR 5	147..168		6/23 (26%)
		leucine-rich repeat	148..169	CDD:275380	7/23 (30%)
		LRR 6	169..189		7/19 (37%)
		leucine-rich repeat	170..191	CDD:275380	6/20 (30%)
		LRR 7	191..212		1/20 (5%)
		leucine-rich repeat	192..215	CDD:275380	2/22 (9%)
		LRR 8	215..237		8/21 (38%)
		leucine-rich repeat	216..235	CDD:275380	8/18 (44%)
		leucine-rich repeat	236..260	CDD:275380	6/27 (22%)
		LRR 9	238..258		3/19 (16%)
		LRR 10	259..281		8/22 (36%)
		leucine-rich repeat	261..281	CDD:275380	7/19 (37%)
		PCC	265..>344	CDD:188093	18/77 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..395
		EGF	407..438	CDD:333761
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	591..661
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910