DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lrrc8b

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001028722.1	Gene:	Lrrc8b / 433926	MGIID:	2141353	Length:	803	Species:	Mus musculus

Alignment Length:	528	Identity:	124/528 - (23%)
Similarity:	197/528 - (37%)	Gaps:	130/528 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DETKENPAPDMQNSQEQEPYVHLQHLQQQQQQNPQTVQQLSQITVNRTSKSASVTPTGIRENVML 99
            :::..:..||::|.     :..:.||..|...              ..||..|:..:.:.||.:
Mouse   352 EKSNYSDIPDVKND-----FAFILHLADQYDP--------------LYSKRFSIFLSEVSENKL- 396

  Fly   100 PSADPEKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWLQKHCHCTGSLEVLRLS 164
                  |:..:..|.:::......:..:.       .|..||......|..:......:|||.|.
Mouse   397 ------KQINLNNEWTVERLKSKLVKNSQ-------DKVELHLFMLNGLPDNVFELTEMEVLSLE 448

  Fly   165 CRGIGILAVPVNLPNEVVVLDLGNNNLTKLEA--NSF--------FMAPNLEELTLSDNSIINMD 219
                  |...|.||..|..|    .||.:|..  :|.        |:..||..|.|....:..:
Mouse   449 ------LIPEVKLPAAVAQL----VNLRELHVYHSSLVVDHPALAFLEENLRILRLKFTEMGKI- 502

  Fly   220 PNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEG 284
            |...:.|..||.|.|..|.|    |:      ||:||.|.|          ...|:.||||.|:.
Mouse   503 PRWVFHLKNLKELYLSGCVL----PE------QLSSLHLEG----------FQDLKNLRTLYLKS 547

  Fly   285 NLFYRIP---TNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            :| .|||   |:.|..|:.|...|.||.|:.:.|                           ||.:
Mouse   548 SL-SRIPQVVTDLLPSLQKLSLDNEGSKLVVLNN---------------------------LKKM 584

  Fly   347 TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWIND----TELPRSMQMLDMRANPLSTI 407
            ..||.|||....:..:|..:..|:.|.||.:..|.|:.:.:    ..|| |:..|.:..|.::.|
Mouse   585 VNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEIISFQHLP-SLSCLKLWHNNIAYI 648

  Fly   408 SPGAFRGMSKLRKLILSDVRTLRSFP-ELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELK 471
             |.....:|.|.:|.|.. ..:.|.| :|..|..|..|.|....:..:|..: :....|:...:.
Mouse   649 -PAQIGALSNLEQLFLGH-NNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEI-QYLTNLQYFAVT 710

  Fly   472 TNSLKRIPN-LSSCRDLRLLDLSSNQIEKIQGKPFNG-LKQLNDLLLSYNRIKALPQDAFQGIPK 534
            .|:::.:|: |..|:.|:.|.|..|.:..:  .|..| |..|..|.|:.|.::.||
Mouse   711 NNNIEMLPDGLFQCKKLQCLLLGRNSLTDL--SPLVGELSNLTHLELTGNYLETLP--------- 764

  Fly   535 LQLLDLEG 542
               ::|||
Mouse   765 ---VELEG 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/20 (35%)
		LRR_RI	180..>383	CDD:238064	58/215 (27%)
		leucine-rich repeat	183..204	CDD:275380	6/30 (20%)
		LRR_8	203..263	CDD:290566	19/59 (32%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	23/61 (38%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	12/25 (48%)
		LRR_8	299..359	CDD:290566	13/59 (22%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	2/22 (9%)
		LRR_RI	327..567	CDD:238064	54/223 (24%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	16/58 (28%)
		leucine-rich repeat	372..393	CDD:275380	7/24 (29%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	16/69 (23%)
		leucine-rich repeat	441..464	CDD:275378	4/22 (18%)
		LRR_8	487..545	CDD:290566	16/57 (28%)
		leucine-rich repeat	487..510	CDD:275380	7/23 (30%)
		leucine-rich repeat	511..534	CDD:275380	6/22 (27%)
		LRR_8	533..589	CDD:290566	3/10 (30%)
		leucine-rich repeat	535..558	CDD:275380	3/8 (38%)
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrrc8b	NP_001028722.1	Pannexin_like	1..334	CDD:372171
		LRR 1	415..439		4/30 (13%)
		PLN00113	<428..>692	CDD:215061	86/325 (26%)
		LRR 2	440..462		9/27 (33%)
		LRR 3	464..486		5/21 (24%)
		leucine-rich repeat	465..488	CDD:275380	4/22 (18%)
		LRR 4	488..509		5/21 (24%)
		leucine-rich repeat	489..511	CDD:275380	5/22 (23%)
		LRR 5	511..532		11/30 (37%)
		leucine-rich repeat	512..539	CDD:275380	14/46 (30%)
		LRR 6	539..559		10/20 (50%)
		leucine-rich repeat	540..562	CDD:275380	11/22 (50%)
		LRR 7	562..582		7/46 (15%)
		leucine-rich repeat	563..586	CDD:275380	9/49 (18%)
		LRR	<578..794	CDD:227223	55/237 (23%)
		LRR 8	586..607		6/20 (30%)
		leucine-rich repeat	587..609	CDD:275380	7/21 (33%)
		LRR 9	609..630		5/20 (25%)
		leucine-rich repeat	610..634	CDD:275380	7/24 (29%)
		LRR 10	634..655		5/21 (24%)
		leucine-rich repeat	635..657	CDD:275380	4/22 (18%)
		LRR 11	657..678		6/21 (29%)
		leucine-rich repeat	658..680	CDD:275380	7/22 (32%)
		LRR 12	680..701		4/21 (19%)
		LRR 13	703..724		4/20 (20%)
		leucine-rich repeat	704..726	CDD:275380	5/21 (24%)
		LRR 14	726..747		6/22 (27%)
		leucine-rich repeat	727..749	CDD:275380	7/23 (30%)
		LRR 15	749..771		9/33 (27%)
		leucine-rich repeat	750..772	CDD:275380	9/32 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910