DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lgr3

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_733115.1	Gene:	Lgr3 / 43098	FlyBaseID:	FBgn0039354	Length:	765	Species:	Drosophila melanogaster

Alignment Length:	805	Identity:	189/805 - (23%)
Similarity:	274/805 - (34%)	Gaps:	227/805 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 EGNLFYRIPTNALAGLRTLEALNLG-SNLLTIIN-----DEDFPRMPNLIVLLLKRNQIMKISAG 341
            :|.:.|   ....|.||....|:.. :||:.|.|     |..|.....|..|.||.|.|.::..|
  Fly   136 QGTILY---CGRYAKLRRFPRLSSEVTNLIIIRNNLTLRDNIFANFTRLQKLTLKYNNISRVPLG 197

  Fly   342 ALKNLTALKVLELDDNLISSLPEGL-SKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLS 405
            :...|..|:.|||..|.:|.||.|: ..|..||.|.:.:|.|.     .||
  Fly   198 SFSGLFHLERLELSHNNVSHLPHGVFLGLHSLQWLFLVNNHLH-----HLP-------------- 243

  Fly   406 TISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLEL 470
                                |..||.|      ..||.|.|.|                 ..|.|
  Fly   244 --------------------VEQLRFF------RRLEWLVLSR-----------------NRLTL 265

  Fly   471 KTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKL 535
            :...|.:||.                              |.::.|.:|||:.:.::.|..:..|
  Fly   266 RNVQLPKIPT------------------------------LYEVYLDFNRIEYIGEETFSQLDNL 300

  Fly   536 QLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTF 600
            .||||:.|.|::||..||:..|.:.|:.|..|...||  ||                     :||
  Fly   301 HLLDLQHNLITHIHGRAFANLTNMRDIRLVGNPIKEL--SG---------------------ETF 342

  Fly   601 ---PRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHN 662
               .|::.|.|       |.:|:...||.                   |...|.|.:|:
  Fly   343 LHNTRLEALSL-------ALMPIHISSSL-------------------MEPLNISFLNL------ 375

  Fly   663 LSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMST 727
                          |.|.::....:.....:..|..:.:.|                 .:..|:
  Fly   376 --------------TGIRYDHIDFEAINSMRNLTYIIYDRF-----------------FYCSMT- 408

  Fly   728 EDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLV 792
                |....|.|.........||.....||...||:..|::.||..|::.....|.:......::
  Fly   409 ----PRVRMCKPSTDGVSSFQDLLSKPVLRYSAWVMATLTIAGNVLVLWGRFIYRDENVAVTMVI 469

  Fly   793 CNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLE 857
            .|||.||..||.||..:.:.|.....|:....:.|..|..|.|.|.|||.|||:|:..||.::||
  Fly   470 RNLALADMLMGFYLVTIGVQDYRYRNEYYKVVLDWITSWQCTLIGTLAVSSSEVSMLILAFMSLE 534

  Fly   858 RNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLV-----GVSDYRKFA-VCLPFETTTG 916
            |...|......::.:..:.....:...|:..:.:|:.|::     .:..|..:: .|.|......
  Fly   535 RFLLIADPFRGHRSIGNRVMWLALICIWITGVGLAVAPVLLWRTSTLPYYGSYSGTCFPLHIHEA 599

  Fly   917 -PASLTYVISLMFINGCAFLTLM-----GCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTDFLC 975
             |....| .:.:|:.....|.:|     ...|...|..|.:......|...|.|...:|.|||||
  Fly   600 FPMGWLY-SAFVFLGVNLLLLVMIAMLYTALLISIWRTRSATPLTLLDCEFAVRFFFIVLTDFLC 663

  Fly   976 WSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDC-------VTLCK 1033
            |.||....|...|... ||.:......||||||||..||.||...|.:::...       :|..|
  Fly   664 WVPIIVMKIWVFFNYN-ISDDIYAWLVVFVLPLNSAVNPLLYTFTTPKYRNQIFLRGWKKITSRK 727

  Fly  1034 HFEESRVVGGGGPGGRGAVARTKRG 1058
            ..|          .|.|.||.|..|
  Fly   728 RAE----------AGNGNVATTTTG 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	34/106 (32%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566	7/28 (25%)
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380	4/16 (25%)
		LRR_8	299..359	CDD:290566	21/65 (32%)
		leucine-rich repeat	301..324	CDD:275380	7/28 (25%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	58/240 (24%)
		leucine-rich repeat	349..371	CDD:275380	10/22 (45%)
		LRR_8	370..425	CDD:290566	7/54 (13%)
		leucine-rich repeat	372..393	CDD:275380	7/20 (35%)
		leucine-rich repeat	394..415	CDD:275380	0/20 (0%)
		leucine-rich repeat	418..486	CDD:275380	14/67 (21%)
		leucine-rich repeat	441..464	CDD:275378	5/22 (23%)
		LRR_8	487..545	CDD:290566	12/57 (21%)
		leucine-rich repeat	487..510	CDD:275380	0/22 (0%)
		leucine-rich repeat	511..534	CDD:275380	6/22 (27%)
		LRR_8	533..589	CDD:290566	19/55 (35%)
		leucine-rich repeat	535..558	CDD:275380	11/22 (50%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tm_4	764..>892	CDD:304433	35/127 (28%)
		7tm_1	770..1017	CDD:278431	73/258 (28%)
Lgr3	NP_733115.1	LDLa	32..65	CDD:238060
		LRR_8	179..239	CDD:290566	22/59 (37%)
		leucine-rich repeat	181..204	CDD:275380	8/22 (36%)
		LRR_RI	<196..354	CDD:238064	63/279 (23%)
		leucine-rich repeat	205..228	CDD:275380	10/22 (45%)
		leucine-rich repeat	229..252	CDD:275380	11/67 (16%)
		leucine-rich repeat	253..275	CDD:275380	9/38 (24%)
		LRR_8	274..334	CDD:290566	22/89 (25%)
		leucine-rich repeat	276..299	CDD:275380	6/22 (27%)
		leucine-rich repeat	300..323	CDD:275380	11/22 (50%)
		leucine-rich repeat	324..347	CDD:275380	9/45 (20%)
		7tm_1	447..704	CDD:278431	73/258 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910