DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and lum

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001002059.1	Gene:	lum / 415149	ZFINID:	ZDB-GENE-040625-24	Length:	344	Species:	Danio rerio

Alignment Length:	339	Identity:	91/339 - (26%)
Similarity:	149/339 - (43%)	Gaps:	72/339 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 KHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNS 214
            :.|.|..:... .:.|....:..:|: :|..:..|.|.||.:.:::|..|..|.:|..|.|.:|:
Zfish    43 QECECPINFPT-AMYCNERNLKFIPI-VPTGIKYLYLQNNFIEEIKAGVFDNATDLRWLVLDNNN 105

  Fly   215 IIN--MDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKL 277
            |.:  :.......|..|::|...:..| :.||               |:...|||
Zfish   106 ITSDKIQAGTIDKLGSLEKLLFSHNKL-TKPP---------------GSLSKSLD---------- 144

  Fly   278 RTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIIN-DEDFPRMPNLIVLLLKRNQIMKISAG 341
             .|:|.||.....|.|.|||:..|..::|..|.||..: ...|..:.:||:|.:..|::.|:.:|
Zfish   145 -ELKLIGNKLTSFPANTLAGMENLTTVHLSKNKLTTESLTGAFKGLKSLILLDVSENKLKKLPSG 208

  Fly   342 ALKNLTALKVLELDDNLISSLPEG-LSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLS 405
            .   ..:|.:|..|:|.|.|:|.| |:||..||.|.|:.|:|              :|      |
Zfish   209 V---PASLLMLYADNNDIDSIPNGYLAKLPLLQYLRISHNKL--------------VD------S 250

  Fly   406 TISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVP----ANLCR-QTP-- 463
            .:..|.| .:|.|.:|.|| ...|::.||:.  .:||.|.|.   :.|:.    .|:|| .:|
Zfish   251 GVPAGVF-NVSSLLELDLS-FNKLKTIPEIN--ESLEHLYLQ---VNEINKFELTNICRFSSPVN 308

  Fly   464 --RLKSLELKTNSL 475
              ||::|.|..|::
Zfish   309 YSRLRTLRLDGNNI 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	2/20 (10%)
		LRR_RI	180..>383	CDD:238064	59/206 (29%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	12/61 (20%)
		leucine-rich repeat	205..228	CDD:275380	6/24 (25%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_8	252..311	CDD:290566	16/58 (28%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		LRR_8	299..359	CDD:290566	16/60 (27%)
		leucine-rich repeat	301..324	CDD:275380	6/23 (26%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	47/159 (30%)
		leucine-rich repeat	349..371	CDD:275380	11/22 (50%)
		LRR_8	370..425	CDD:290566	14/54 (26%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	21/67 (31%)
		leucine-rich repeat	441..464	CDD:275378	9/31 (29%)
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lum	NP_001002059.1	LRRNT	41..68	CDD:279764	4/26 (15%)
		LRR_RI	58..274	CDD:238064	72/268 (27%)
		LRR_8	70..132	CDD:290566	15/61 (25%)
		leucine-rich repeat	72..95	CDD:275380	7/22 (32%)
		leucine-rich repeat	96..121	CDD:275380	6/24 (25%)
		LRR_8	121..177	CDD:290566	21/82 (26%)
		leucine-rich repeat	122..142	CDD:275380	6/35 (17%)
		leucine-rich repeat	143..166	CDD:275380	11/33 (33%)
		LRR_8	166..247	CDD:290566	28/83 (34%)
		leucine-rich repeat	167..191	CDD:275380	6/23 (26%)
		leucine-rich repeat	192..212	CDD:275380	6/22 (27%)
		leucine-rich repeat	213..236	CDD:275380	11/22 (50%)
		LRR_8	235..292	CDD:290566	22/83 (27%)
		leucine-rich repeat	237..261	CDD:275380	10/44 (23%)
		leucine-rich repeat	282..311	CDD:275380	9/31 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910