DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and tlr20.2

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001170914.2	Gene:	tlr20.2 / 403140	ZFINID:	ZDB-GENE-040220-6	Length:	950	Species:	Danio rerio

Alignment Length:	539	Identity:	125/539 - (23%)
Similarity:	194/539 - (35%)	Gaps:	156/539 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 ICERWLQKHCHCTGSLEVLRLS-----------CRGI-----GILAVPVNLPNEVVVLDLGNNNL 191
            :|. ||...||.....|....|           ||.:     .:..:|.||.|.:|..|||.:.:
Zfish    25 VCS-WLAGKCHIESDGEEFSFSTSSPRKRNTTVCRSVTDMKEDLRGLPANLQNLIVQTDLGYHGV 88

  Fly   192 TKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSL 256
                                      :.||:|.....|:.|.:..| |..:||::|.||..:|:|
Zfish    89 --------------------------LAPNSFLRFGSLENLEIVGC-LSEVPPEAFNGLTNVTTL 126

  Fly   257 QLNGNALVSLDGDC------LGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIIN 315
            .|      |....|      ...|..|.:|.|.......:|:|....:..|..|:|.|..|..::
Zfish   127 TL------SCSQQCTEVAFDFSRLTSLTSLSLSDYSLSLLPSNVFEKIPQLRWLHLCSECLKDLS 185

  Fly   316 DEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSN 380
            :            :|.|          |||:.:||.|.|.:.:::.|......:..:.|:|...|
Zfish   186 E------------VLCR----------LKNVKSLKYLGLGNTMLTRLQYPNCSVFNVSEISTKFN 228

  Fly   381 RLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKL--ILSDVRTLRSFPEL-------- 435
                         ::..|:....|..:..||.:...||.:|  .:|....||....:
Zfish   229 -------------IERADLLLGKLEHVDEGALKVFGKLSRLYFTVSSKNFLRDLSLIGVHQISVI 280

  Fly   436 ----------EACHALEILKLDRAGIQEVPANL---------CRQTPRL--------KSLE-LKT 472
                      :.|.|.::..:....:.....||         |:|...:        |::. |..
Zfish   281 IATVDVLNVDDLCVAAKLYSVKSVDVDYDTINLSLTSKISDGCKQIGYIMLENNIFGKTVNLLDV 345

  Fly   473 NSLKRI-PNLSS---------CRDLRLLDLSSNQ--------------IEKIQGKPFNGLKQLND 513
            |||.:| .||:|         ..|.:.|..|..|              |:||....|.....|..
Zfish   346 NSLFQIFSNLTSVTIDKHVLRSNDFQSLCASFPQTVKKISDMVLRIIRIDKIVSHQFMCFVNLKT 410

  Fly   514 LLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNN-IFPELPESGL 577
            |.|:.::...:...||.|:.||:.|:|..|:||.||:..|||...|..|:|..| :|...||| .
Zfish   411 LKLAMSKFSVIEDFAFIGLNKLKELNLHSNKISSIHQHTFSGLHELRVLDLNENPLFHIEPES-F 474

  Fly   578 RALLHLKTFNNPKLREFPP 596
            |.|::|:|.....| .|||
Zfish   475 RHLINLRTLLLGDL-NFPP 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/36 (19%)
		LRR_RI	180..>383	CDD:238064	45/208 (22%)
		leucine-rich repeat	183..204	CDD:275380	3/20 (15%)
		LRR_8	203..263	CDD:290566	15/59 (25%)
		leucine-rich repeat	205..228	CDD:275380	3/22 (14%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	15/64 (23%)
		leucine-rich repeat	253..276	CDD:275380	6/28 (21%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		LRR_8	299..359	CDD:290566	14/59 (24%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..348	CDD:275380	5/22 (23%)
		LRR_RI	327..567	CDD:238064	67/301 (22%)
		leucine-rich repeat	349..371	CDD:275380	5/21 (24%)
		LRR_8	370..425	CDD:290566	10/56 (18%)
		leucine-rich repeat	372..393	CDD:275380	3/20 (15%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	20/115 (17%)
		leucine-rich repeat	441..464	CDD:275378	4/31 (13%)
		LRR_8	487..545	CDD:290566	18/71 (25%)
		leucine-rich repeat	487..510	CDD:275380	7/36 (19%)
		leucine-rich repeat	511..534	CDD:275380	6/22 (27%)
		LRR_8	533..589	CDD:290566	24/56 (43%)
		leucine-rich repeat	535..558	CDD:275380	11/22 (50%)
		leucine-rich repeat	559..580	CDD:275380	9/21 (43%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
tlr20.2	NP_001170914.2	leucine-rich repeat	358..383	CDD:275380	4/24 (17%)
		LRR_8	407..466	CDD:290566	22/58 (38%)
		leucine-rich repeat	408..431	CDD:275380	6/22 (27%)
		LRR_4	431..471	CDD:289563	17/39 (44%)
		leucine-rich repeat	432..455	CDD:275380	11/22 (50%)
		leucine-rich repeat	456..479	CDD:275380	10/23 (43%)
		leucine-rich repeat	496..539	CDD:275380
		leucine-rich repeat	540..583	CDD:275380
		leucine-rich repeat	584..608	CDD:275380
		leucine-rich repeat	609..634	CDD:275380
		leucine-rich repeat	635..658	CDD:275380
		TIR	802..940	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910