DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and tlr5b

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001124067.2	Gene:	tlr5b / 403139	ZFINID:	ZDB-GENE-040219-15	Length:	881	Species:	Danio rerio

Alignment Length:	582	Identity:	138/582 - (23%)
Similarity:	223/582 - (38%)	Gaps:	160/582 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 EVLRLS--CRGIGILAVPVN--------LPNEVVVLDLGNNNLTKLEANSFFMAPNLE------- 206
            ||::.:  |..||..|:.:|        ||..|..:||..|::.:|...||....:|:
Zfish    23 EVVKSTSECSVIGYNAICINRGLHQVPELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQ 87

  Fly   207 ------------------ELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGL-------------- 239
                              .|.|..|..:.::..||.|||.|:.|:|..|.|
Zfish    88 TPGLVIRNNTFRGLSSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLT 152

  Fly   240 ------------KSLPPQS-FQGLAQLTSLQLNGNALVSL-DGDCLG----HLQKLR-------- 278
                        |.:.|.| |..:.:...|.|..|.:.|: :.|.|.    |...||
Zfish   153 SLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQGKHFTLLRLSSITLQD 217

  Fly   279 ---------------------TLRLEGNLFYRIPT----NALAGLRTLEAL------NLGSNL-L 311
                                 ||.|.||.|.....    :|:||.: :::|      |:||:. .
Zfish   218 MNEYWLGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAGTK-IQSLILSNSYNMGSSFGH 281

  Fly   312 TIINDED-----------------------------FPRMPNLIVLLLKRNQIMKISAGALKNLT 347
            |...|.|                             |....:|..|.|.:|:|.||...|...||
Zfish   282 TNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLT 346

  Fly   348 ALKVLELDDNLISSLPEGL-SKLSQLQELSITSNRLRWINDTE---LPRSMQMLDMRANPLSTIS 408
            .|..|.|..|.:.|:...: ..|.:|:.|.::.|.:|.:.|..   || :::.|::..|.:.::.
Zfish   347 HLLKLNLSQNFLGSIDSRMFENLDKLEVLDLSYNHIRALGDQSFLGLP-NLRKLNLTGNAVESVH 410

  Fly   409 PGAFRGMSKLRKLIL--SDVRTLRSFPELEACHALEILKLDRAGIQEVP--ANLCRQTPRLKSLE 469
              .|..:..|.||.|  :.:.::.|.|.:  .|.|..|.|:...:..:.  ..:.|:.|:::::.
Zfish   411 --TFAALPNLNKLYLGKNRISSVSSLPNI--AHNLSTLDLEFNKLHALSDLYTILREFPQIENIF 471

  Fly   470 LKTNSLKRIPN-----LSSCRDLRLLDLSSNQIEKIQGKPFN---GLKQLNDLLLSYNRIKALPQ 526
            |:.|:.....|     ||....|..|.|||.|:...:||..|   .|.||..|.|:.|.:::||:
Zfish   472 LQGNTFSSCYNQKQIVLSDKLQLLHLGLSSMQLIWSEGKCLNVFADLHQLQQLSLTANGLQSLPK 536

  Fly   527 DAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNN 588
            |.|:.:..|..|||..|.:.|:..:.|.  .:|:.|||..|....:..:....|.:|...||
Zfish   537 DIFKDLTSLFFLDLSFNSLKYLPTDVFP--KSLQILNLDYNSIYSVDPNLFSTLSYLSLMNN 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	8/29 (28%)
		LRR_RI	180..>383	CDD:238064	70/329 (21%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	21/111 (19%)
		leucine-rich repeat	205..228	CDD:275380	8/47 (17%)
		leucine-rich repeat	229..252	CDD:275380	9/49 (18%)
		LRR_8	252..311	CDD:290566	22/103 (21%)
		leucine-rich repeat	253..276	CDD:275380	7/27 (26%)
		leucine-rich repeat	277..300	CDD:275380	11/55 (20%)
		LRR_8	299..359	CDD:290566	22/95 (23%)
		leucine-rich repeat	301..324	CDD:275380	8/58 (14%)
		leucine-rich repeat	325..348	CDD:275380	9/22 (41%)
		LRR_RI	327..567	CDD:238064	72/255 (28%)
		leucine-rich repeat	349..371	CDD:275380	6/22 (27%)
		LRR_8	370..425	CDD:290566	14/59 (24%)
		leucine-rich repeat	372..393	CDD:275380	7/23 (30%)
		leucine-rich repeat	394..415	CDD:275380	3/20 (15%)
		leucine-rich repeat	418..486	CDD:275380	17/76 (22%)
		leucine-rich repeat	441..464	CDD:275378	4/24 (17%)
		LRR_8	487..545	CDD:290566	24/60 (40%)
		leucine-rich repeat	487..510	CDD:275380	10/25 (40%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	16/56 (29%)
		leucine-rich repeat	535..558	CDD:275380	7/22 (32%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
tlr5b	NP_001124067.2	leucine-rich repeat	55..78	CDD:275380	7/22 (32%)
		leucine-rich repeat	79..103	CDD:275380	1/23 (4%)
		LRR_8	102..164	CDD:290566	13/61 (21%)
		leucine-rich repeat	104..127	CDD:275380	7/22 (32%)
		leucine-rich repeat	128..153	CDD:275380	5/24 (21%)
		leucine-rich repeat	154..178	CDD:275380	4/23 (17%)
		leucine-rich repeat	179..236	CDD:275380	9/56 (16%)
		LRR_RI	<224..478	CDD:238064	57/259 (22%)
		LRR_8	298..356	CDD:290566	14/57 (25%)
		leucine-rich repeat	300..323	CDD:275380	1/22 (5%)
		leucine-rich repeat	324..347	CDD:275380	9/22 (41%)
		LRR_8	346..404	CDD:290566	15/58 (26%)
		leucine-rich repeat	348..371	CDD:275380	6/22 (27%)
		leucine-rich repeat	372..395	CDD:275380	7/23 (30%)
		LRR_8	394..451	CDD:290566	14/61 (23%)
		leucine-rich repeat	396..417	CDD:275380	3/22 (14%)
		leucine-rich repeat	441..482	CDD:275380	7/40 (18%)
		leucine-rich repeat	494..520	CDD:275380	10/25 (40%)
		LRR_8	520..577	CDD:290566	21/58 (36%)
		leucine-rich repeat	521..544	CDD:275380	8/22 (36%)
		leucine-rich repeat	545..563	CDD:275380	6/17 (35%)
		leucine-rich repeat	567..587	CDD:275380	5/19 (26%)
		LRRCT	596..645	CDD:214507	1/1 (100%)
		TIR	712..846	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910