DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and tlr5a

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:XP_001919052.2 Gene:tlr5a / 403138 ZFINID:ZDB-GENE-040219-14 Length:881 Species:Danio rerio


Alignment Length:674 Identity:155/674 - (22%)
Similarity:247/674 - (36%) Gaps:208/674 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 CRGIGILAVPVNLPNEVVVLDLGNNNLTK--------LEA-----------------NSFFMAPN 204
            |...|:..|| .:...:..:||..|.:.:        |||                 |||....|
Zfish    34 CMDRGLQEVP-KISTYITNVDLSKNRIAELNETSFSHLEALEVLILMHQTPGLVIRRNSFMRLSN 97

  Fly   205 LEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGD 269
            |..|.|..|..:.:|..||.||:.||.|:|..|||..             ||         |.|:
Zfish    98 LTSLQLDYNHHLRIDAGAFNGLSDLKNLTLTQCGLDD-------------SL---------LSGN 140

  Fly   270 CLGHLQKLRTLRLEGNLFYRI-PTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRN 333
            .|..|..|..|.|..|...|: |.:....:|....|:|..|.:..|.:||      |:....|..
Zfish   141 FLKPLMSLEMLDLSRNNIRRVQPASFFLNMRRFHVLDLTFNKVKSICEED------LLNFQGKHF 199

  Fly   334 QIMKISAGALKNL----------------TALKVLELDDN----------------------LIS 360
            .::::|:..|:::                |::..|:|..|                      :||
Zfish   200 TLLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGFNVDMAKRFFDAISSTKIQSLIIS 264

  Fly   361 SL-------------PE-----GLSK-------LSQLQELSITSNRLRWINDTELPRSMQMLDMR 400
            :.             |:     ||..       ||.....|:|.:...:::|      ::.:.:.
Zfish   265 NTYRIGKSSGDNSKDPDKSTFSGLKSSGIKSFDLSNSSIFSLTYSVFSYLSD------LEQITLA 323

  Fly   401 ANPLSTISPGAFRGMSKLRKLILS-------DVRTLRSFPELEACHALEILKLDRAGIQEVPANL 458
            .:.::.|...||.||:.|.||.||       |.||.::.      ..||:|.|....|..:.:..
Zfish   324 ESQINKIENNAFLGMTNLLKLNLSKNFLGYIDFRTFQNL------KGLEVLDLSYNHIWRLGSQS 382

  Fly   459 CRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKA 523
            .:..|.|.||.|..|||..:...::...|..|.|..|.|:.:...| |..|.|..|.|.:|:|.:
Zfish   383 FQGLPNLLSLNLTGNSLGHVYTFATLPKLEKLYLGDNNIQYVYEIP-NIAKHLKTLDLQFNQIAS 446

  Fly   524 L--------------------------PQDAFQGIPK-LQLLDLEGNEISYIHKE-----AFSGF 556
            :                          |||..:.:.: :|:|||....:..|..|     .|...
Zfish   447 MSELYTILDEFPQIEEVVFRGNQLLYCPQDNHEVLSQNIQVLDLSFAGLQVIWSEGKCLNVFDDL 511

  Fly   557 TALEDLNLGNNIFPELPE---SGLRALLHLK-TFNNPKLREFPPPDTFPR-IQTLILSY------ 610
            ..||.|:|.:|:...||:   ..|.:||.|. :||:.|   :.|.|.||: :|.|.|.|      
Zfish   512 HQLEVLHLSSNLLQSLPKDIFKDLTSLLILDLSFNSLK---YLPTDVFPKTLQVLHLDYNSIYSV 573

  Fly   611 ---AYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEF-DMTLWNNSMMNIWPQMHNLSKQLGASM 671
               .:...::|.|  |::.           |..|.:. |...|.| ..|| ..:|::.....||.
Zfish   574 DPNLFSTLSYLSL--MNND-----------FRCDCDLKDFQTWLN-QTNI-TFVHSIEDVTCASP 623

  Fly   672 HDPW-----ETAINFNEEQLQTQT 690
            .|.:     .::|...:|:.:.:|
Zfish   624 EDQYMVPVVSSSIQCEDEEEERRT 647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 4/13 (31%)
LRR_RI 180..>383 CDD:238064 62/291 (21%)
leucine-rich repeat 183..204 CDD:275380 9/45 (20%)
LRR_8 203..263 CDD:290566 19/59 (32%)
leucine-rich repeat 205..228 CDD:275380 9/22 (41%)
leucine-rich repeat 229..252 CDD:275380 7/22 (32%)
LRR_8 252..311 CDD:290566 16/59 (27%)
leucine-rich repeat 253..276 CDD:275380 6/22 (27%)
leucine-rich repeat 277..300 CDD:275380 6/23 (26%)
LRR_8 299..359 CDD:290566 15/97 (15%)
leucine-rich repeat 301..324 CDD:275380 6/22 (27%)
leucine-rich repeat 325..348 CDD:275380 4/38 (11%)
LRR_RI 327..567 CDD:238064 70/341 (21%)
leucine-rich repeat 349..371 CDD:275380 9/68 (13%)
LRR_8 370..425 CDD:290566 14/61 (23%)
leucine-rich repeat 372..393 CDD:275380 3/20 (15%)
leucine-rich repeat 394..415 CDD:275380 3/20 (15%)
leucine-rich repeat 418..486 CDD:275380 21/74 (28%)
leucine-rich repeat 441..464 CDD:275378 5/22 (23%)
LRR_8 487..545 CDD:290566 20/84 (24%)
leucine-rich repeat 487..510 CDD:275380 7/22 (32%)
leucine-rich repeat 511..534 CDD:275380 8/48 (17%)
LRR_8 533..589 CDD:290566 20/65 (31%)
leucine-rich repeat 535..558 CDD:275380 7/27 (26%)
leucine-rich repeat 559..580 CDD:275380 8/23 (35%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
tlr5aXP_001919052.2 LRR_8 50..107 CDD:290566 13/56 (23%)
leucine-rich repeat 50..72 CDD:275380 4/21 (19%)
leucine-rich repeat 73..97 CDD:275380 3/23 (13%)
LRR_8 96..158 CDD:290566 27/83 (33%)
leucine-rich repeat 98..121 CDD:275380 9/22 (41%)
leucine-rich repeat 122..147 CDD:275380 13/46 (28%)
leucine-rich repeat 148..172 CDD:275380 6/23 (26%)
leucine-rich repeat 173..230 CDD:275380 10/62 (16%)
LRR_RI <218..478 CDD:238064 56/272 (21%)
LRR_8 291..349 CDD:290566 15/63 (24%)
leucine-rich repeat 297..316 CDD:275380 4/18 (22%)
leucine-rich repeat 317..340 CDD:275380 5/22 (23%)
LRR_8 339..399 CDD:290566 19/65 (29%)
leucine-rich repeat 341..364 CDD:275380 8/28 (29%)
leucine-rich repeat 365..388 CDD:275380 5/22 (23%)
LRR_8 387..444 CDD:290566 20/57 (35%)
leucine-rich repeat 389..410 CDD:275380 7/20 (35%)
leucine-rich repeat 411..433 CDD:275380 7/22 (32%)
leucine-rich repeat 434..513 CDD:275380 15/78 (19%)
leucine-rich repeat 485..499 CDD:275378 4/13 (31%)
LRR_8 513..570 CDD:290566 22/59 (37%)
leucine-rich repeat 514..537 CDD:275380 8/22 (36%)
leucine-rich repeat 538..559 CDD:275380 10/23 (43%)
leucine-rich repeat 560..581 CDD:275380 4/20 (20%)
LRRCT 589..638 CDD:214507 12/61 (20%)
TIR 705..839 CDD:214587
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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