DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and tlr8b

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001373638.1	Gene:	tlr8b / 403136	ZFINID:	ZDB-GENE-040219-12	Length:	1015	Species:	Danio rerio

Alignment Length:	862	Identity:	170/862 - (19%)
Similarity:	289/862 - (33%)	Gaps:	294/862 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WSWRLALC-------PLLLQLLLQLLLLPPSAMGHDETKENPAPDMQNSQEQEPYVHLQH----- 59
            |:||...|       .:.|....:.|...|..:..:.|..|.|.:..::..::.:.:|.:
Zfish    19 WAWRKLPCDVNLSNTSVTLDCSERYLKKIPKNLIWNTTNLNLANNKIHNISKDAFWNLNNVTWID 83

  Fly    60 -----LQQQQQQNPQTVQQLSQI-TVNRTSKSASVTPTGIRENVMLPSADPEKEAQILYEKSLQE 118
                 :::..:::.....:|:.: |:...:...||.|..:...:...|.:..      :.||:::
Zfish    84 LRRNQIEKCHEKDNGVFSRLTNLKTLLLDNNKISVLPKNLPAGLQWLSLNSN------HIKSIEQ 142

  Fly   119 YHGSQLSTASTATDVIAGKRTLHSI-CERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVV 182
               |.....:..|.:...|...|:| .|..:|........|..|:||..|:.  .||..||..:.
Zfish   143 ---SDFKGMTKLTVLKLNKNCYHNISAELTIQNETFQHLQLTELQLSKNGLH--NVPFALPRTLH 202

  Fly   183 VLDLGNNNLTKLEANSFFMAPNLEELTLS------------------DNSIINMDPNAFYGLAKL 229
            .|.|..|.:..:..:.......|:.|.||                  :|:.:.:.||||..|::|
Zfish   203 NLSLLLNRIDHVHESDLNHLTRLKVLDLSGNCPICFTTPFPCTSCQTNNNALQIHPNAFSKLSQL 267

  Fly   230 KRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVS----------------LD----------- 267
            :.|.|....|:|:....||.|..|..|.|:.|:|:|                :|
Zfish   268 QDLRLSGNSLQSINSMWFQNLTNLKYLYLSFNSLISEFESGQFFSVLPQVEVVDISYNNPSERIY 332

  Fly   268 -----GDCLGHLQKLRTLRLEGNLFYRIPTN---ALAGLRTLEALNLGSNLL------------- 311
                 .:....|:.|:||.|||.:|:::..:   .|..||.|..|||..|.|
Zfish   333 PRLKLSEGFSRLESLQTLHLEGYIFHKLSEDDLRPLFSLRNLSVLNLAVNFLQQVNLSVFRNFHN 397

  Fly   312 ----------------------------------------------------------------- 311

Zfish   398 LSLISLIDNRLTFSSPIRRWEGQSKSGFKDDNQGDHREGPYIHTNEEFRHYPPFTKAECLATGPV 462

  Fly   312 ---------------------------------TIINDEDFPRMPNLIVLLLKRNQIMKISAGAL 343
                                             :..|..:|...|.|..|.|..|:|...|..||
Zfish   463 LDLSRNNIYHVNPPLFTGAENITCLNLSSNFIVSYFNGTEFAHFPKLKYLDLSHNRIYMHSDSAL 527

  Fly   344 KNLTALKVLELDDNL----ISSLPEGLSKLSQLQELSITSNRLRW------INDTELPRSMQMLD 398
            ..|.||:||:|..|.    ::.:...|:.|..||.|.:.:  |.|      .|.|....|:..|.
Zfish   528 SELKALEVLDLSHNQHYFEVAGVRNCLTFLENLQFLKVLN--LSWNEINMLTNKTLQSDSLNELQ 590

  Fly   399 MRANPLSTI------SPGAFRGMSKLRKLILS---------DVRTLRSFPELEACHALEILKLDR 448
            .:.|.|..:      ....|:.:|.|..|.:|         |:  ...||:     .|..:.:.|
Zfish   591 FQGNRLDIMWKKQRGYQSLFKSLSNLTYLDISYNKLSEIPDDI--FDYFPK-----TLRYISMSR 648

  Fly   449 AGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSS--CRDLRLLDLSSNQIEKIQGKPFNGLKQL 511
            ..:.:......:..|:|::|:|..|.|:.:|...|  .|.|::||||.|||.|::......:|.|
Zfish   649 NTLTDFAWEQLQSLPQLETLDLSKNKLRVVPRKLSKHTRSLKVLDLSHNQISKLRYSFLENVKSL 713

  Fly   512 NDLLLSYNRIKALPQDAFQ--GIPKLQLLDLEGNEIS----------YIHKEAFSGFTALEDLNL 564
            ..|..:.|::|.|...:|.  ...:||:|||:.|.|.          ::.|..    |.|.  .|
Zfish   714 QILNFANNKLKHLGASSFTTGSNHQLQILDLQRNPIHCTCNLLDFILWLEKSD----TILP--RL 772

  Fly   565 GNNIFPELPES------------------GLRALLHLKTFNNPKLREFPPPDTFPRIQTLI---- 607
            ..::..:||||                  .:..:|::.|.:               :.||:
Zfish   773 ATDVLCDLPESKRGHPMVSLDFKNACINNSIAEILYILTSS---------------VITLVMCTT 822

  Fly   608 ---------LSYAYHCC 615
                     :||||:.|
Zfish   823 IGIHVFYWDISYAYNFC 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	8/20 (40%)
		LRR_RI	180..>383	CDD:238064	68/370 (18%)
		leucine-rich repeat	183..204	CDD:275380	3/20 (15%)
		LRR_8	203..263	CDD:290566	22/77 (29%)
		leucine-rich repeat	205..228	CDD:275380	10/40 (25%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	23/93 (25%)
		leucine-rich repeat	253..276	CDD:275380	8/54 (15%)
		leucine-rich repeat	277..300	CDD:275380	9/25 (36%)
		LRR_8	299..359	CDD:290566	25/174 (14%)
		leucine-rich repeat	301..324	CDD:275380	8/133 (6%)
		leucine-rich repeat	325..348	CDD:275380	9/22 (41%)
		LRR_RI	327..567	CDD:238064	73/278 (26%)
		leucine-rich repeat	349..371	CDD:275380	7/25 (28%)
		LRR_8	370..425	CDD:290566	16/75 (21%)
		leucine-rich repeat	372..393	CDD:275380	7/26 (27%)
		leucine-rich repeat	394..415	CDD:275380	4/26 (15%)
		leucine-rich repeat	418..486	CDD:275380	16/78 (21%)
		leucine-rich repeat	441..464	CDD:275378	2/22 (9%)
		LRR_8	487..545	CDD:290566	22/59 (37%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	6/24 (25%)
		LRR_8	533..589	CDD:290566	17/83 (20%)
		leucine-rich repeat	535..558	CDD:275380	8/32 (25%)
		leucine-rich repeat	559..580	CDD:275380	6/38 (16%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
tlr8b	NP_001373638.1	leucine-rich repeat	36..57	CDD:275380	3/20 (15%)
		leucine-rich repeat	58..78	CDD:275380	3/19 (16%)
		LRR_8	64..116	CDD:404697	3/51 (6%)
		leucine-rich repeat	79..105	CDD:275380	1/25 (4%)
		leucine-rich repeat	106..121	CDD:275380	3/14 (21%)
		LRR_8	126..190	CDD:404697	14/72 (19%)
		leucine-rich repeat	127..150	CDD:275380	4/31 (13%)
		leucine-rich repeat	151..179	CDD:275380	6/27 (22%)
		PLN00113	180..>735	CDD:215061	120/565 (21%)
		leucine-rich repeat	180..224	CDD:275380	12/45 (27%)
		leucine-rich repeat	225..266	CDD:275380	10/40 (25%)
		leucine-rich repeat	267..290	CDD:275380	8/22 (36%)
		leucine-rich repeat	347..373	CDD:275380	9/25 (36%)
		leucine-rich repeat	374..397	CDD:275380	6/22 (27%)
		leucine-rich repeat	462..483	CDD:275380	0/20 (0%)
		leucine-rich repeat	484..508	CDD:275380	2/23 (9%)
		leucine-rich repeat	509..532	CDD:275380	9/22 (41%)
		leucine-rich repeat	563..615	CDD:275380	10/53 (19%)
		leucine-rich repeat	586..607	CDD:275380	3/20 (15%)
		leucine-rich repeat	616..640	CDD:275380	6/30 (20%)
		leucine-rich repeat	641..664	CDD:275380	2/22 (9%)
		leucine-rich repeat	665..688	CDD:275380	7/22 (32%)
		leucine-rich repeat	689..712	CDD:275380	9/22 (41%)
		leucine-rich repeat	713..732	CDD:275380	5/18 (28%)
		LRRCT	747..795	CDD:214507	10/53 (19%)
		TIR	855..997	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910