Protein Alignment rk and tlr18

DIOPT Version :9

• Sequence 1: NP_476702.1
• Gene: rk / 34819
• FlyBaseID: FBgn0003255
• Length: 1360
• Species: Drosophila melanogaster
• Sequence 2: NP_001082819.1
• Gene: tlr18 / 403133
• ZFINID: ZDB-GENE-040220-2
• Length: 854
• Species: Danio rerio
• Alignment Length: 774
• Identity: 152/774 - (19%)
• Similarity: 284/774 - (36%)
• Gaps: 221/774 - (28%)

  Fly   150 KHC----HCTGSLEVLRLSCRGIGILAVP-VNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELT 209
            ||.    .||.:.:.|...|:|:.:.:|| ..||:.:..|||..|.:..:....|.....|..|.
Zfish    18 KHAKAKQSCTIAFDKLSADCKGLRLDSVPTTQLPDSLEELDLSFNTIHVIRKQDFVKLTYLRVLK 82

  Fly   210 LSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGN--ALVSLDGDCLG 272
            |:.|:|..:..:||.|...|:.|:|.|..|..:|.::.:.|..|..|:::.|  :..|| |....
Zfish    83 LNFNNISLVLDDAFQGNLLLEELNLFNNSLTEIPFKALEPLTNLKVLEMSNNLYSQASL-GAAFL 146

  Fly   273 HLQKLRTLRLEGNLFYRIPTNALAGLRTLE----ALNLGS-----------NLLT--IINDEDFP 320
            :..:|:.|.:.|.|...:.:..:..|:.:.    |:..|:           :|.|  :..|..|.
Zfish   147 NFNQLKVLSIGGPLVSSLGSRDIYVLKNISLDKFAVKTGTGFRDYEPGYFKSLSTKHLWFDIAFD 211

  Fly   321 RMPNLIVLLLK------------RN----------------------------------QIMKIS 339
            :.|:|:..:||            ||                                  ::|::
Zfish   212 KNPDLLPKMLKDLANKTFDVLRFRNLFEFQYYTGKRDIFYGLQYVNAQTLTFYRGKFNEEVMRM- 275

  Fly   340 AGALKN--LTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRAN 402
              ||||  ::.:|.|||                .|.:.:.:.||.:..:...|.....:|...:|
Zfish   276 --ALKNVEISPIKALEL----------------LLIDFARSQNRTQGSSVKNLSLDRLVLSDISN 322

  Fly   403 PLSTISPGAFRGMSKLRKLILSDVR----TLRSFPELEACHALEIL------------------- 444
            |.......:|..::.:||.|:.:|.    ...|:||:::...|:|.
Zfish   323 PDIMRFDWSFTWLNHVRKFIVWNVNFNSVPCDSWPEMKSVELLDISNNQLLDSYIYNPLCDTRNT 387

  Fly   445 --KLDRAGIQEVP-------ANLCRQTPRLKSLELKTNSLKRIPNLSSC---------------- 484
              |||...:....       |:|.:...:|.::::..|.|:.:.| .:|
Zfish   388 LHKLDTFNVSHNRLTSLSDLASLTKDFVKLTTIDMSHNQLQYLGN-GACDWRKTITKVIGNHNSL 451

  Fly   485 ---------RDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALP---QDAFQGIPKLQL 537
                     ..:..||||.:.::::....||...:|.:||||.|:||.:|   ::.:     |:.
Zfish   452 TSDSFKCLPTSVNFLDLSYSSLDQLDMDYFNKASELTELLLSGNKIKFIPSGWKNRY-----LRT 511

  Fly   538 LDLEGNEISYIHKEAFSGFTALEDLNLGNN-------IFPELPESGLRALLHLKTF-NNPKLREF 594
            |.|:||....:..::|....:|..|..|||       ::..:.|:..:..:.:..: ||.|...
Zfish   512 LALDGNSFGLVSMKSFKDMLSLRVLTAGNNPYHCTCDLYTFIQETTSKGKVTITDWPNNYKCYH- 575

  Fly   595 PPPDTFPRIQTLILSYA-YHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWP 658
              |:..  :.|::..|: .|....:.||.:.|...|:.|...::.
Zfish   576 --PERL--LNTMVSKYSPGHLACDITLVIIISVSTTAAVVLVIML-------------------- 616

  Fly   659 QMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFS 723
                    |....|.||.....:           ||..:   :|....:..|....|.|...:..
Zfish   617 --------LCYIFHVPWYVKATY-----------QIIRA---KYRAHKEGLGQGVDYAFHAFISY 659

  Fly   724 GMSTEDF-QPGSVQCLP-MPGPFLPCADLFDWWTLRCGVWVV--FLLSLLGNGTVVFVL 778
            ..|..|: :...:.||. :..|:..|....|:..   |.|::  .:.::..:..|:|||
Zfish   660 SHSDADWVRNHLLPCLENVKPPYRLCIHERDFIP---GKWIIDNIIENIENSRKVIFVL 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/21 (29%)
		LRR_RI	180..>383	CDD:238064	55/269 (20%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	18/61 (30%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	13/75 (17%)
		leucine-rich repeat	253..276	CDD:275380	6/24 (25%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		LRR_8	299..359	CDD:290566	21/124 (17%)
		leucine-rich repeat	301..324	CDD:275380	6/39 (15%)
		leucine-rich repeat	325..348	CDD:275380	10/70 (14%)
		LRR_RI	327..567	CDD:238064	64/347 (18%)
		leucine-rich repeat	349..371	CDD:275380	4/21 (19%)
		LRR_8	370..425	CDD:290566	11/54 (20%)
		leucine-rich repeat	372..393	CDD:275380	4/20 (20%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	19/124 (15%)
		leucine-rich repeat	441..464	CDD:275378	7/50 (14%)
		LRR_8	487..545	CDD:290566	20/60 (33%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	9/25 (36%)
		LRR_8	533..589	CDD:290566	13/63 (21%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	6/27 (22%)
		7tm_4	764..>892	CDD:304433	4/15 (27%)
		7tm_1	770..1017	CDD:278431	4/9 (44%)
tlr18	NP_001082819.1	LRR_8	53..>98	CDD:316378	12/44 (27%)
		leucine-rich repeat	54..77	CDD:275380	5/22 (23%)
		leucine-rich repeat	78..101	CDD:275380	8/22 (36%)
		leucine-rich repeat	102..125	CDD:275380	7/22 (32%)
		leucine-rich repeat	126..150	CDD:275380	6/24 (25%)
		LRR	<345..>519	CDD:227223	36/179 (20%)
		leucine-rich repeat	362..390	CDD:275380	2/27 (7%)
		leucine-rich repeat	391..416	CDD:275380	4/24 (17%)
		leucine-rich repeat	417..440	CDD:275380	5/23 (22%)
		leucine-rich repeat	441..462	CDD:275380	0/20 (0%)
		leucine-rich repeat	463..486	CDD:275380	6/22 (27%)
		leucine-rich repeat	487..508	CDD:275380	9/20 (45%)
		leucine-rich repeat	509..532	CDD:275380	6/22 (27%)
		TIR	653..791	CDD:214587	14/66 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910