DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and tlr2

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:XP_005170910.1 Gene:tlr2 / 403125 ZFINID:ZDB-GENE-040219-6 Length:818 Species:Danio rerio


Alignment Length:491 Identity:106/491 - (21%)
Similarity:177/491 - (36%) Gaps:129/491 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 NEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSL- 242
            ||:::|:|..|.|..:..::|....|||.|.||.|::.|:.|:.|:.|..|::|:|......:: 
Zfish   104 NELIILNLHKNKLRHIHRDAFKSQHNLEVLDLSLNNLNNLSPSWFHKLKSLQQLNLVGNPYSTVG 168

  Fly   243 PPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLG 307
            |...|:.|..|.:|.|...:|..|..:.|..|..|..:...|:........:|...|.:.:::|.
Zfish   169 PAPIFKSLVNLRTLHLGSPSLRELHKNGLDVLTHLDEMTFFGSNLRSYENGSLKAARPIGSVSLS 233

  Fly   308 -SNLL--------TIINDEDFPRMPNLIVLLLKRNQIMK----------ISAGALKNLTALKVLE 353
             .||.        .::.|...|.     .||:.::..||          :..|..|:||......
Zfish   234 LQNLFESDPELVSKVLQDVSHPE-----TLLIIKDVTMKTNTSTEPFKMVKEGGTKSLTFQNSST 293

  Fly   354 LDDNLISSLP--------------------------------------------EGLSKLSQLQE 374
            .|..|.|.|.                                            ||....|.:.|
Zfish   294 TDQALTSFLEFMDGSPLSFIGLEDIQFVGIGEWQKAKYTHHDSLRTAYLRNIEIEGFFGFSSMIE 358

  Fly   375 LSITSNRLRWIN------------DTELPRSMQMLDMRANPLS--TISPGAFRGMSKLRKLILSD 425
            |.........::            .|.|.::::.:|:..|.|:  ||.|..:.|....:.|.:.:
Zfish   359 LGFLLKHFHNVSVINATVFVIPKETTFLLKNLEYMDLSQNLLTDLTIQPTLYTGSGAYQNLNMLN 423

  Fly   426 VRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIP----------- 479
            |             :..:||  ..|:.   :.|.....:||.|:|..||...:|           
Zfish   424 V-------------SQNVLK--SLGLM---SRLVTNLKKLKYLDLSYNSFVSMPEKCSWPVTLRF 470

  Fly   480 -NLSSCR----------DLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIP 533
             ||||.:          .|.:||||.|.::..:.:    ...|..|:|:.||:..||....  .|
Zfish   471 LNLSSTKLSTLTPCLPSSLTVLDLSENDLKAFKQR----FPHLTTLILTGNRLMKLPDGKL--FP 529

  Fly   534 KLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIF 569
            .|..|.::.|.:...::.:...|..|..|..|.|.|
Zfish   530 SLNTLLIQRNALRMFNQSSLRSFKTLLYLEAGANNF 565

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 106/491 (22%)
LRR_RI 180..>383 CDD:238064 56/266 (21%)
leucine-rich repeat 183..204 CDD:275380 5/20 (25%)
LRR_8 203..263 CDD:290566 20/60 (33%)
leucine-rich repeat 205..228 CDD:275380 10/22 (45%)
leucine-rich repeat 229..252 CDD:275380 6/23 (26%)
LRR_8 252..311 CDD:290566 13/59 (22%)
leucine-rich repeat 253..276 CDD:275380 7/22 (32%)
leucine-rich repeat 277..300 CDD:275380 3/22 (14%)
LRR_8 299..359 CDD:290566 15/78 (19%)
leucine-rich repeat 301..324 CDD:275380 5/31 (16%)
leucine-rich repeat 325..348 CDD:275380 7/32 (22%)
LRR_RI 327..567 CDD:238064 64/329 (19%)
leucine-rich repeat 349..371 CDD:275380 6/65 (9%)
LRR_8 370..425 CDD:290566 13/68 (19%)
leucine-rich repeat 372..393 CDD:275380 4/32 (13%)
leucine-rich repeat 394..415 CDD:275380 6/22 (27%)
leucine-rich repeat 418..486 CDD:275380 17/89 (19%)
leucine-rich repeat 441..464 CDD:275378 4/22 (18%)
LRR_8 487..545 CDD:290566 17/57 (30%)
leucine-rich repeat 487..510 CDD:275380 6/22 (27%)
leucine-rich repeat 511..534 CDD:275380 7/22 (32%)
LRR_8 533..589 CDD:290566 10/37 (27%)
leucine-rich repeat 535..558 CDD:275380 4/22 (18%)
leucine-rich repeat 559..580 CDD:275380 5/11 (45%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431