DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and lhcgr

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_991188.1	Gene:	lhcgr / 402920	ZFINID:	ZDB-GENE-040806-3	Length:	708	Species:	Danio rerio

Alignment Length:	832	Identity:	244/832 - (29%)
Similarity:	378/832 - (45%)	Gaps:	175/832 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   368 KLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLIL---SDVRTL 429
            ::.:..:.|||.|     :.|...:|:..|.:....:.|||..:|.|:..:|::.:   |.|.|:
Zfish    26 EICRCSQKSITCN-----SATGSQKSLSRLVLNYISVKTISSRSFDGLKGVRRIEIAQSSSVETI 85

  Fly   430 RSFPELEACHAL----EILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLR-- 488
            .|    ||.:.|    ||...:...:..:......|.|:|:.|.:....:...|:|:|...|.
Zfish    86 ES----EAFNNLPNVSEISIQNTRNLVHIQQRAFNQLPKLRYLSISNTGISVFPDLTSIFSLEAH 146

  Fly   489 -LLDLSSN-QIEKIQGKPFNGL-KQLNDLLLSYNRIKALPQDAFQG--IPKLQLLDLEGNEISYI 548
             :||:..| .:..:....|.|: .:...:.|..|..:.:...||.|  |.||.|.:  ..::..:
Zfish   147 FILDICDNLNLRSVPSNAFTGMTSEYATMNLFNNGFQEIESHAFNGTKIDKLVLKN--SRDLRVV 209

  Fly   549 HKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYH 613
            |::||.|......|::.:.....||..||.::|.|...:...|::.||..:...::...|::..|
Zfish   210 HEDAFKGALGPTVLDVSSTALETLPSHGLESVLMLTARSAFALKKLPPLKSLKSLREAQLTFPSH 274

  Fly   614 CCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSM-MNIWPQMHNLSKQLGASMHDPWET 677
            |||.:.                             |:||. .::...:.|.|...|.: ..|.:.
Zfish   275 CCALIN-----------------------------WDNSRDGSVNSALRNRSSYCGDN-SSPADL 309

  Fly   678 AINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDF----QPGSVQCL 738
            :...:::.|::..   |.:|.:|:.|...|...|                 |.    |..::||.
Zfish   310 SAISSDDSLESDV---IGSSSVEDTFGSIDFHYP-----------------DLDLCQQRQALQCS 354

  Fly   739 PMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMG 803
            |....|.||.|:..:..||..:|.:.:|::.||..|:.||..||.|:.|||||:|:||.||..:|
Zfish   355 PEADAFNPCEDIAGFSFLRVAIWFINILAIAGNLVVLLVLFTSRCKLTVPRFLMCHLAFADLCIG 419

  Fly   804 IYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHL 868
            |||.::|.||..|.|.:...||.||....|.::|||:|...|||:|||:.||:||.:.||||:.|
Zfish   420 IYLLMIATVDLRTRGHYSHHAIEWQTGAGCDIAGFLSVFGGELSIYTLSTITVERWHTITHALRL 484

  Fly   869 NKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISLMFINGCA 933
            .:||.|.||..||::||:..|.|||:||:|||.|.|.::|||.:..| |.|..|||.|:..|..|
Zfish   485 ERRLGLSQASLIMTIGWLLCLAMALLPLIGVSSYSKVSMCLPMDIET-PLSQAYVILLLLFNVGA 548

  Fly   934 FLTLMGCYLKMYWAIRGSQ-AWNTNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQLISLEQ 997
            ||.:.|||:.:|.|:|..: .....|::||||||:|:||||||.:||:||:|:|.|.:.||::..
Zfish   549 FLVICGCYVCIYSAVRNPEFPGRAADAKIAKRMAVLIFTDFLCMAPISFFAISAAFKVPLITVTN 613

  Fly   998 AKIFTVFVLPLNSCCNPFLYAIMTKQFKKD-CVTLCKHFEESRVVGGGGPGGRGAVARTKRGDLP 1061
            :||..|...|:|||.|||||||.|:.|:|| |:.|..
Zfish   614 SKILLVLFYPINSCANPFLYAIFTRAFRKDACILLSS---------------------------- 650

  Fly  1062 PPLLPAAAVAHPPGCRCLRMLPSEMPNWHKMEQTPSMWQRLRTFCCGENRRRRKQRRQPQQRRQR 1126
                        .|| |               |:.:...|::|: |.||..|.|
Zfish   651 ------------MGC-C---------------QSKANLYRMKTY-CSENINRSK----------- 675

  Fly  1127 AYTAAAANPYQYQFAELRQQRQNRASSISSENFCSSRSSSWRHGPPSSAPVP 1178
                                    :||.|:.|....|:..|....|...|.|
Zfish   676 ------------------------SSSGSNANSKGPRAVMWMSSFPQLTPRP 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	4/14 (29%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064	49/212 (23%)
		leucine-rich repeat	349..371	CDD:275380	0/2 (0%)
		LRR_8	370..425	CDD:290566	13/57 (23%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	17/74 (23%)
		leucine-rich repeat	441..464	CDD:275378	4/26 (15%)
		LRR_8	487..545	CDD:290566	15/64 (23%)
		leucine-rich repeat	487..510	CDD:275380	6/27 (22%)
		leucine-rich repeat	511..534	CDD:275380	6/24 (25%)
		LRR_8	533..589	CDD:290566	14/55 (25%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433	62/127 (49%)
		7tm_1	770..1017	CDD:278431	124/247 (50%)
lhcgr	NP_991188.1	leucine-rich repeat	47..70	CDD:275380	6/22 (27%)
		LRR_5	58..216	CDD:290045	40/163 (25%)
		leucine-rich repeat	71..95	CDD:275380	8/27 (30%)
		leucine-rich repeat	96..120	CDD:275380	3/23 (13%)
		leucine-rich repeat	121..142	CDD:275380	5/20 (25%)
		leucine-rich repeat	143..170	CDD:275380	6/26 (23%)
		leucine-rich repeat	171..194	CDD:275380	5/22 (23%)
		leucine-rich repeat	195..219	CDD:275380	8/25 (32%)
		leucine-rich repeat	220..257	CDD:275380	8/36 (22%)
		GnHR_trans	283..356	CDD:289164	17/93 (18%)
		7tm_1	386..633	CDD:278431	124/247 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2091
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810