DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and tlr21

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001186264.1	Gene:	tlr21 / 402884	ZFINID:	ZDB-GENE-040220-4	Length:	989	Species:	Danio rerio

Alignment Length:	847	Identity:	181/847 - (21%)
Similarity:	304/847 - (35%)	Gaps:	269/847 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 LSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALA 296
            |::.:..::.:..|||..|..||:|.|:.|.:.::|.|...:|..|:||.|..|....:..:..:
Zfish    65 LTISHSNIEYVQSQSFDHLPNLTALILDANHITNIDKDAFNNLHHLQTLNLSCNNISFLHRDVFS 129

  Fly   297 GLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISA--GALKNLTALKVLELDDNLI 359
            .|..|..|.||||.||..:...|..:.||.:|.|:||.:...|:  .::.|||:|..|:|..|
Zfish   130 DLHNLTQLLLGSNKLTNPDKYLFSSLTNLKILDLRRNHLYNFSSVVESITNLTSLIKLDLSFN-- 192

  Fly   360 SSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRG-MSKLRKLIL 423
                    ||:.||            :.|.||.|:.:|.:..|.|.|:  |..:. :..::||.|
Zfish   193 --------KLTTLQ------------HSTHLPESLALLYLGDNKLKTL--GCDKSFLMNVKKLDL 235

  Fly   424 SDVRTLRS----------------------------FPELEACHALEILKLDRAGIQ----EVPA 456
            ||.:.|.|                            :|.:...|      :|.:|::    ...:
Zfish   236 SDNKNLASKSFLGLKLENITYLRLRFTNISIFKLLTYPNVHPWH------IDFSGLKLKNSHALS 294

  Fly   457 NLC----------RQTPRL----KSL-ELKTNSLKRIPNLSSCRDLRLLDLSSNQIE-------- 498
            :||          .|.|::    .|: .||.|:.:..|:::     |.:|||.|:::
Zfish   295 SLCVLMRNHSHKHLQIPKMLLQSNSIGALKNNTFRYCPSIT-----REMDLSRNELKSAGCLQFL 354

  Fly   499 ---------KIQGKPFNGL---------KQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEI 545
                     |::......|         ..|.:|...||||..:...||...|||::|:|..|.|
Zfish   355 HNQTQLKSLKMEHNHLTKLTSCNKAEIHNSLTNLSYRYNRILQISGYAFSNTPKLEILELNINII 419

  Fly   546 SYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFN--NPKLREFPPPDTFPRIQTLIL 608
            :|:..:|.||...|:.|.|.||:..::.......|.:|||.|  |.::             .:|.
Zfish   420 AYMDHKALSGLKDLKTLRLDNNLLSDIYNDSFEDLTNLKTLNLRNNEI-------------AVIF 471

  Fly   609 SYAYHCCAFLPLVAMSSQKKTSQVQ-----------------------EAVLFP--SDAEFDMTL 648
            :|.:...:.|.::.:.. .|.||::                       :.|||.  |.....:.|
Zfish   472 NYTFQNLSKLDILDLGG-NKISQLKPHAFDGLYSLTNLYLDRNHLKMIDVVLFGKLSGTLQVLDL 535

  Fly   649 WNNSMMNIWPQMH----NLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVS 709
            ..|.:|......|    |:|:.....::......||     |..:...:..||....|...:.:
Zfish   536 QGNMIMYFTEHTHSPFKNMSRLYDLKLNGQQPNGIN-----LLPRAFFRGLTSLKSLYLTNNHI- 594

  Fly   710 GPATGYGFGTGLFSGMSTEDFQPGSVQCLPM----PGPFLPCADLFDWWTLRCGVWVVFLLSLLG 770
                 .|||...|..:...|:......|..:    .|.|.....|........|: ..|...:.|
Zfish   595 -----IGFGDETFDDLKNLDYLTLDNSCAGVAQLQSGIFKSLQKLRTLSLENMGI-KSFSKDVFG 653

  Fly   771 NGTVVFVLLCSRSKM---DVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVL 832
            |.|.:..|..:|:.|   |:.  |:.||...     ||:.:.:
Zfish   654 NLTGLKTLHLNRNPMMSLDIS--LLDNLTNL-----IYIDMRS---------------------- 689

  Fly   833 CQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLV 897
            |.||  ....:|:|..:|:                :||||.....
Zfish   690 CPLS--CGCHNSDLQNWTI----------------MNKRLQFPHL-------------------- 716

  Fly   898 GVSDYRKFAVCLP---------FETTTGPASLTYV-ISLMFINGCAFLTLM-----GCYLKMYWA 947
                   |.:..|         |:|     .:.|: |.|.|.:..:.||::     ..|:|:||.
Zfish   717 -------FNITCPDHPGSYFHNFDT-----KVCYLDIELYFFSSTSTLTILLTLIPLLYVKLYWK 769

  Fly   948 IR 949
            .:
Zfish   770 FK 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	46/152 (30%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566	10/30 (33%)
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380	5/19 (26%)
		LRR_8	252..311	CDD:290566	20/58 (34%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	23/61 (38%)
		leucine-rich repeat	301..324	CDD:275380	9/22 (41%)
		leucine-rich repeat	325..348	CDD:275380	8/24 (33%)
		LRR_RI	327..567	CDD:238064	74/315 (23%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	14/55 (25%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		leucine-rich repeat	394..415	CDD:275380	5/21 (24%)
		leucine-rich repeat	418..486	CDD:275380	20/114 (18%)
		leucine-rich repeat	441..464	CDD:275378	5/36 (14%)
		LRR_8	487..545	CDD:290566	21/83 (25%)
		leucine-rich repeat	487..510	CDD:275380	7/48 (15%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	21/57 (37%)
		leucine-rich repeat	535..558	CDD:275380	9/22 (41%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433	23/130 (18%)
		7tm_1	770..1017	CDD:278431	36/198 (18%)
tlr21	NP_001186264.1	leucine-rich repeat	65..85	CDD:275380	5/19 (26%)
		LRR_8	84..144	CDD:290566	20/59 (34%)
		leucine-rich repeat	86..109	CDD:275380	8/22 (36%)
		LRR_RI	107..350	CDD:238064	68/277 (25%)
		leucine-rich repeat	110..133	CDD:275380	6/22 (27%)
		leucine-rich repeat	134..157	CDD:275380	9/22 (41%)
		LRR_8	156..217	CDD:290566	24/82 (29%)
		leucine-rich repeat	158..183	CDD:275380	8/24 (33%)
		leucine-rich repeat	184..206	CDD:275380	11/43 (26%)
		leucine-rich repeat	207..229	CDD:275380	5/23 (22%)
		leucine-rich repeat	230..253	CDD:275380	7/22 (32%)
		LRR_RI	<336..540	CDD:238064	49/217 (23%)
		leucine-rich repeat	360..383	CDD:275380	2/22 (9%)
		leucine-rich repeat	385..408	CDD:275380	8/22 (36%)
		LRR_8	407..467	CDD:290566	22/59 (37%)
		leucine-rich repeat	409..432	CDD:275380	9/22 (41%)
		leucine-rich repeat	433..456	CDD:275380	6/22 (27%)
		LRR_8	455..515	CDD:290566	11/73 (15%)
		leucine-rich repeat	457..480	CDD:275380	7/35 (20%)
		leucine-rich repeat	481..504	CDD:275380	4/23 (17%)
		leucine-rich repeat	505..529	CDD:275380	4/23 (17%)
		leucine-rich repeat	530..556	CDD:275380	5/25 (20%)
		LRR_8	555..615	CDD:290566	12/70 (17%)
		leucine-rich repeat	557..583	CDD:275380	3/30 (10%)
		LRR_8	582..668	CDD:290566	19/92 (21%)
		leucine-rich repeat	584..607	CDD:275380	5/28 (18%)
		leucine-rich repeat	608..633	CDD:275380	4/24 (17%)
		leucine-rich repeat	634..657	CDD:275380	5/23 (22%)
		leucine-rich repeat	658..679	CDD:275380	5/22 (23%)
		leucine-rich repeat	682..694	CDD:275378	5/40 (13%)
		TIR	797..942	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910