DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and LRRD1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001155000.1	Gene:	LRRD1 / 401387	HGNCID:	34300	Length:	860	Species:	Homo sapiens

Alignment Length:	645	Identity:	156/645 - (24%)
Similarity:	270/645 - (41%)	Gaps:	142/645 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 QQQQQNPQ---------TVQQLSQITVNRTSKSASVTPTGIRENV--MLPSADPEKEAQI----- 110
            ::|::|.|         |.|.||.:| .||::..::......|.|  :.|....|.:.|:
Human    79 EEQKKNLQFSETSTRTGTSQSLSSLT-GRTAEYQALVNFLSHETVGEVSPQVSEENQKQLGLGAD 142

  Fly   111 -----LYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWLQKHCHCTGS-----LEVLRLSC 165
                 |..|.|||:          ..|::..|...:...::...|......|     ||:|.|..
Human   143 NFTVNLEAKGLQEF----------PKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQE 197

  Fly   166 RGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLK 230
            .|:..|...:.|.:.:.:|::.:|:::.: ........|:.:|...:|.|.|. |:....|..|:
Human   198 NGLSSLPSEIQLLHNLRILNVSHNHISHI-PKEISQLGNIRQLFFYNNYIENF-PSDLECLGNLE 260

  Fly   231 RLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNAL 295
            .|||....|:.: |.:...|..|..|.|..|.|.:.. ..|..|.||.:|.|.|||...:| ..:
Human   261 ILSLGKNKLRHI-PDTLPSLKTLRVLNLEYNQLTTFP-KALCFLPKLISLDLTGNLISSLP-KEI 322

  Fly   296 AGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQI----MKISAGALKNLTALKVLELDD 356
            ..|:.||.|.:..|.||.:..|.|.      :|.:|..|:    :::.:..::|...|::|.||.
Human   323 RELKNLETLLMDHNKLTFLAVEIFQ------LLKIKELQLADNKLEVISHKIENFRELRILILDK 381

  Fly   357 NLISSLPEGLSKLSQLQELSITSNRLRWINDTELPR------SMQMLDMRANPLSTIS------- 408
            ||:.::||.:|..:.|:.||::.|:|     ||||:      :::.|.:..|.:..|:
Human   382 NLLKNIPEKISCCAMLECLSLSDNKL-----TELPKYIHKLNNLRKLHVNRNNMVKITDCISHLN 441

  Fly   409 ---------------PGAFRGMSKLRKLILSDVRTLRSFP-ELEACHALEILKLDRAGIQEVPAN 457
                           |...:...|:.|:.|| ...:..|| .|.|..:|..|.::...|.|:|.:
Human   442 NICSLEFSGNIITDVPIEIKNCQKIIKIELS-YNKIMYFPLGLCALDSLYYLSVNGNYISEIPVD 505

  Fly   458 L-----------------------CRQTPRLKSLELKTNSLKRIP-------------------- 479
            :                       | ....||.|:|..|.:|:||
Human   506 ISFSKQLLHLELSENKLLIFSEHFC-SLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFE 569

  Fly   480 ----NLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQD--AFQGIPKLQLL 538
                .|.:..:|::||||.||::||.....| ||.:..|..|.|:....|.:  ..|.:.:|.:.
Human   570 TFPRELCTLENLQVLDLSENQLQKISSDICN-LKGIQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633

  Fly   539 DLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPES--GLRALLHLKTFNNPKLREFPP 596
            .::|.:::.:..| .|..|.|::|::.||...|:|.:  .||.|:.|..:|| ::...||
Human   634 QIKGRKLTRLPGE-LSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNN-QISYLPP 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	7/20 (35%)
		LRR_RI	180..>383	CDD:238064	57/206 (28%)
		leucine-rich repeat	183..204	CDD:275380	2/20 (10%)
		LRR_8	203..263	CDD:290566	18/59 (31%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	20/58 (34%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	17/63 (27%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	4/26 (15%)
		LRR_RI	327..567	CDD:238064	73/321 (23%)
		leucine-rich repeat	349..371	CDD:275380	9/21 (43%)
		LRR_8	370..425	CDD:290566	16/82 (20%)
		leucine-rich repeat	372..393	CDD:275380	9/26 (35%)
		leucine-rich repeat	394..415	CDD:275380	4/42 (10%)
		leucine-rich repeat	418..486	CDD:275380	22/115 (19%)
		leucine-rich repeat	441..464	CDD:275378	6/45 (13%)
		LRR_8	487..545	CDD:290566	19/59 (32%)
		leucine-rich repeat	487..510	CDD:275380	11/22 (50%)
		leucine-rich repeat	511..534	CDD:275380	5/24 (21%)
		LRR_8	533..589	CDD:290566	16/57 (28%)
		leucine-rich repeat	535..558	CDD:275380	4/22 (18%)
		leucine-rich repeat	559..580	CDD:275380	8/22 (36%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
LRRD1	NP_001155000.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103		7/23 (30%)
		LRR 1	139..163		6/33 (18%)
		leucine-rich repeat	145..165	CDD:275380	6/29 (21%)
		LRR 2	164..186		3/21 (14%)
		LRR_8	166..223	CDD:290566	11/56 (20%)
		leucine-rich repeat	166..189	CDD:275380	2/22 (9%)
		LRR 3	187..210		6/22 (27%)
		leucine-rich repeat	190..212	CDD:275380	7/21 (33%)
		LRR 4	211..233		2/22 (9%)
		leucine-rich repeat	213..235	CDD:275380	2/22 (9%)
		LRR 5	235..256		6/21 (29%)
		leucine-rich repeat	236..258	CDD:275380	6/22 (27%)
		LRR 6	257..279		6/22 (27%)
		LRR_8	258..315	CDD:290566	20/58 (34%)
		leucine-rich repeat	259..281	CDD:275380	7/22 (32%)
		LRR_RI	262..501	CDD:238064	67/253 (26%)
		LRR 7	281..302		6/21 (29%)
		leucine-rich repeat	282..304	CDD:275380	7/22 (32%)
		LRR 8	303..325		8/22 (36%)
		leucine-rich repeat	305..327	CDD:275380	8/22 (36%)
		LRR_8	326..384	CDD:290566	17/63 (27%)
		LRR 9	326..348		8/27 (30%)
		leucine-rich repeat	328..350	CDD:275380	8/27 (30%)
		LRR 10	350..371		2/20 (10%)
		LRR 11	372..394		9/21 (43%)
		LRR 12	396..417		9/25 (36%)
		leucine-rich repeat	397..419	CDD:275380	9/26 (35%)
		LRR 13	419..440		3/20 (15%)
		leucine-rich repeat	420..465	CDD:275380	4/44 (9%)
		LRR 14	441..463		1/21 (5%)
		LRR 15	465..486		7/21 (33%)
		LRR 16	487..510		5/22 (23%)
		LRR_8	488..545	CDD:290566	11/57 (19%)
		leucine-rich repeat	489..511	CDD:275380	5/21 (24%)
		leucine-rich repeat	512..534	CDD:275380	1/22 (5%)
		LRR 17	512..532		1/20 (5%)
		LRR 18	533..555		8/21 (38%)
		leucine-rich repeat	535..557	CDD:275380	8/21 (38%)
		LRR_8	557..614	CDD:290566	16/57 (28%)
		LRR 19	557..578		1/20 (5%)
		leucine-rich repeat	558..580	CDD:275380	1/21 (5%)
		LRR 20	579..601		10/22 (45%)
		LRR_RI	<581..>715	CDD:238064	36/114 (32%)
		leucine-rich repeat	581..603	CDD:275380	11/22 (50%)
		LRR 21	603..624		4/20 (20%)
		leucine-rich repeat	604..626	CDD:275380	4/21 (19%)
		leucine-rich repeat	627..652	CDD:275380	4/25 (16%)
		LRR 22	627..650		4/23 (17%)
		LRR_8	651..709	CDD:290566	15/42 (36%)
		LRR 23	651..673		7/21 (33%)
		leucine-rich repeat	653..675	CDD:275380	7/21 (33%)
		LRR 24	675..696		6/18 (33%)
		leucine-rich repeat	676..698	CDD:275380	6/17 (35%)
		LRR 25	697..719
		LRR 26	721..742
		leucine-rich repeat	722..742	CDD:275380
		LRR 27	856..860
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910