DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and LHCGR

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_000224.2	Gene:	LHCGR / 3973	HGNCID:	6585	Length:	699	Species:	Homo sapiens

Alignment Length:	707	Identity:	233/707 - (32%)
Similarity:	365/707 - (51%)	Gaps:	83/707 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 KNLTALKVLELDDNLISSLPEGLSKLSQLQELS-ITSNRLRWINDTELPRSMQMLDMRANPLSTI 407
            :..:||::|:|...|...||..|.:....:..: :....||....|   ..:..|.:...|:..|
Human     3 QRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPT---AGLTRLSLAYLPVKVI 64

  Fly   408 SPGAFRGMSKLRKLILSDVRTL-----RSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKS 467
            ...||||::::.|:.:|.:.:|     .:|..|  .:..|||..:...::.:........||||.
Human    65 PSQAFRGLNEVIKIEISQIDSLERIEANAFDNL--LNLSEILIQNTKNLRYIEPGAFINLPRLKY 127

  Fly   468 LELKTNSLKRIPNLS---SCRDLRLLDLSSN-QIEKIQGKPFNGLKQLNDLLLSY-NRIKALPQD 527
            |.:....:::.|:::   |.....:|::..| .|..|.|..|.|:...:..|..| |..:.:...
Human   128 LSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSH 192

  Fly   528 AFQGIPKLQLLDLEGN-EISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKL 591
            ||.| ..|..|:|:.| .:..:|..||.|.|..:.|::.:.....||..||.::..|...::..|
Human   193 AFNG-TTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSL 256

  Fly   592 REFPPPDTFPRIQTLILSYAYHCCAF--LPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMM 654
            ::.|..:||..:....|:|..|||||  ||   ...|..:..:.|
Human   257 KKLPSRETFVNLLEATLTYPSHCCAFRNLP---TKEQNFSHSISE-------------------- 298

  Fly   655 NIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGT 719
                   |.|||..:       |....|.:.|.:            ....|.::||....|||
Human   299 -------NFSKQCES-------TVRKVNNKTLYS------------SMLAESELSGWDYEYGF-- 335

  Fly   720 GLFSGMSTEDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSK 784
                      ..|.:.:|.|.|..|.||.|:..:..||..:|::.:|:::||.||:||||.||.|
Human   336 ----------CLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYK 390

  Fly   785 MDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVY 849
            :.|||||:|||:.|||.||:||.::|.||:.|.|::...||.||....|..:||..|.:||||||
Human   391 LTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVY 455

  Fly   850 TLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETT 914
            ||.||||||.:.||:||||:::|.|:.|..||..||:|:.::|::||||||:|.|.::|.|.:..
Human   456 TLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVE 520

  Fly   915 TGPASLTYVISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTN-DSRIAKRMALLVFTDFLCWSP 978
            | ..|..|:::::.:|..||..:..||:|:|:|:|..:...|| |::|||:||:|:||||.|.:|
Human   521 T-TLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAP 584

  Fly   979 IAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHF 1035
            |:||:|:|.|.:.||::..:|:..|...|:|||.|||||||.||.|::|...|...|
Human   585 ISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKF 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	8/39 (21%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566	4/14 (29%)
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380	0/3 (0%)
		LRR_RI	327..567	CDD:238064	56/234 (24%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	11/55 (20%)
		leucine-rich repeat	372..393	CDD:275380	3/21 (14%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	15/75 (20%)
		leucine-rich repeat	441..464	CDD:275378	3/22 (14%)
		LRR_8	487..545	CDD:290566	17/60 (28%)
		leucine-rich repeat	487..510	CDD:275380	7/23 (30%)
		leucine-rich repeat	511..534	CDD:275380	6/23 (26%)
		LRR_8	533..589	CDD:290566	15/56 (27%)
		leucine-rich repeat	535..558	CDD:275380	8/23 (35%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433	68/127 (54%)
		7tm_1	770..1017	CDD:278431	122/247 (49%)
LHCGR	NP_000224.2	leucine-rich repeat	51..74	CDD:275380	7/22 (32%)
		LRR_5	62..198	CDD:290045	33/138 (24%)
		leucine-rich repeat	75..99	CDD:275380	5/25 (20%)
		LRR 1	96..115		4/20 (20%)
		leucine-rich repeat	100..124	CDD:275380	3/23 (13%)
		LRR 2	124..145		5/20 (25%)
		leucine-rich repeat	125..150	CDD:275380	5/24 (21%)
		LRR 3	149..171		6/21 (29%)
		leucine-rich repeat	151..174	CDD:275380	7/22 (32%)
		leucine-rich repeat	175..198	CDD:275380	6/23 (26%)
		LRR 4	175..196		5/20 (25%)
		LRR 5	198..220		7/21 (33%)
		leucine-rich repeat	199..223	CDD:275380	8/23 (35%)
		LRR 6	223..244		5/20 (25%)
		leucine-rich repeat	224..244	CDD:275380	5/19 (26%)
		7tm_1	376..623	CDD:278431	122/247 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810