DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rk and Toll-6

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster


Alignment Length:1572 Identity:326/1572 - (20%)
Similarity:542/1572 - (34%) Gaps:477/1572 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LLLQLLLLPPSAMGHDETKENPAPDMQNSQEQEPYVHLQHLQQQQQQNPQTVQQLSQITVNRTSK 84
            ::..:||:.|..:         |.|.|::.|.   :..:|.||||..:...:  :.:..|:.:..
  Fly     1 MIYYMLLILPVVL---------AQDQQHTTES---LSTKHHQQQQLSHSNAI--MGEAGVSNSQL 51

  Fly    85 SASVTPT-GIRENVMLPSADPE----------------KEAQILYEKSLQEYHGSQLSTASTATD 132
            ....||. .:|........||.                .:.:|....:|:..: |:..|  |...
  Fly    52 MQPSTPARTLRPLTAGAGGDPSLYDAPDDCHFMPAAGLDQPEIALTCNLRTVN-SEFDT--TNFS 113

  Fly   133 VIAGKRT--LHSICERWL--------QKHCHCTG----SLEVLRLSCRGIGILAVPVNLPNEVVV 183
            ||..:.|  ||.:|...:        |...|...    |::..:|...|..:|.....|.|    
  Fly   114 VIPAEHTIALHILCNDEIMAKSRLEAQSFAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLRN---- 174

  Fly   184 LDLGNNNLT------KLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSL 242
            |.|..:|:.      ::||::|.:...||.|.||.|:|.::..|.|..|::|..|::....|:.:
  Fly   175 LTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDV 239

  Fly   243 PPQSFQ--------GLAQLTS---------------------LQLNGNALVSLDGDCLGHLQKLR 278
            ....|:        |..:.||                     |.::.|..|.|..:..|.|::||
  Fly   240 NELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLR 304

  Fly   279 TLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLI-VLLLKRNQIMKISAGA 342
            .|.:..|....|...||:||:.|:.|||.||.:..:..|.|.....:| .:.|:.|.|..::...
  Fly   305 VLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQL 369

  Fly   343 LKNLTALKVLELDDNLISSLPEGLSK-----LSQLQELSITSNRLRWINDTEL-PR------SMQ 395
            ..||..|:.|:|..|.|:|  ..:.|     |.:|..|:::.|:|     |:| |.      ::|
  Fly   370 FSNLDQLQALDLSMNQITS--TWIDKNTFVGLIRLVLLNLSHNKL-----TKLEPEIFSDLYTLQ 427

  Fly   396 MLDMRANPLSTISPGAFRGMSKLRKLILS--DVRTLRSFPELEACHALEILKLDRAGIQEVPANL 458
            :|::|.|.|..|:...|..|:.|..|:||  .::.|.:: .|...:.|.:|.||...:..|..:.
  Fly   428 ILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAY-ALNGLYVLSLLSLDNNALIGVHPDA 491

  Fly   459 CRQTPRLKSLELKTNSLKRIP-NLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIK 522
            .|....|:.|.|..|.||.:| .|.:.|.||.:||..|.|..::...|.||..|..|.|..|.::
  Fly   492 FRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLE 556

  Fly   523 ALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALE-------DLNLGNNIFPELPESGLRAL 580
            .:....|:.:|.||:|:|..|.|:.:...||...::::       :||..|.:|..:|     :|
  Fly   557 NITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMP-----SL 616

  Fly   581 LHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFD 645
            |.|...:| :|..|              .|.:                         .||..:  
  Fly   617 LWLNISDN-RLESF--------------DYGH-------------------------VPSTLQ-- 639

  Fly   646 MTLWNNSMMNIWPQMH-----NLSKQLGASMHDPWETA-INFNEEQLQTQTGGQIATSYMEEYFE 704
                       |..:|     :||.:.|.......:|. ::||  |||......|..|....:..
  Fly   640 -----------WLDLHKNRLSSLSNRFGLDSELKLQTLDVSFN--QLQRIGPSSIPNSIELLFLN 691

  Fly   705 EHDVS--GPATGYGFGTGL------FSGMSTEDFQPGSVQCLP------MP------GPFLPCAD 749
            ::.::  .|.| :...|.|      .:.::|.|.:  |::.||      :|      .|| .|..
  Fly   692 DNLITTVDPDT-FMHKTNLTRVDLYANQITTLDIK--SLRILPVWEHRALPEFYIGGNPF-TCDC 752

  Fly   750 LFDWW------------------TLRCGVWVVFLLSLLGNGTVVFV---------LLCSRSKMDV 787
            ..||.                  |:.|        .||.|....::         .||:   ...
  Fly   753 NIDWLQKINHITSRQYPRIMDLETIYC--------KLLNNRERAYIPLIEAEPKHFLCT---YKT 806

  Fly   788 PRFLVCNLAAAD--------------FFMGIYLGILAIVDAATLGEFRMFAIPWQMSVL------ 832
            ..|.||:....|              |....:...:.....|...|... .:|...|.|      
  Fly   807 HCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPR-RVPMDTSELYIDGNN 870

  Fly   833 -CQLSGF-------LAVL----SSELSVYT--------LAVITLERNYAIT------HAIHLNKR 871
             .:|:|.       ||||    |:...:|.        |.::.||.|:.|:      |.:...:.
  Fly   871 FVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRE 935

  Fly   872 LSLKQAGYIMSV-GWVFALIMALMPL-VGVSDYRKFAVCLPFETTTGPASLTYVISLMFING--- 931
            |.| |:..|.|: ...|.::..|..| :..:....|.|   ::.:..|    |::.:...:.   
  Fly   936 LYL-QSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEV---WQLSANP----YLVEISLADNQWS 992

  Fly   932 --CAFLTLMGCYL-----KMYWAIRGSQAWNTNDSRIAKRMA----------------------- 966
              |.:|.....||     |:..|.|.|..:|...|.:.::..                       
  Fly   993 CECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLP 1057

  Fly   967 -LLVFTDFLCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCC--NP-------------- 1014
             |||.|   | :.:|||.:  |||| .....:.||:......|.:.|  :|              
  Fly  1058 LLLVAT---C-AFVAFFGL--IFGL-FCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDA 1115

  Fly  1015 -FLYAIMTKQFKKDCVT----------LCKHFEE----SRVVGGGGPGGRGA------------- 1051
             |.|::..:.|....:.          ||.|:.:    :.:..........|             
  Fly  1116 YFAYSLQDEHFVNQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLY 1180

  Fly  1052 ---------------VARTKR------GDLPPPLLPAAAVAHPPGCRCLRMLPSEMPNWHKME-- 1093
                           |.|.||      ||||.                 |.:..:|.::.:..  
  Fly  1181 NEWSRFEYKSALHELVKRRKRVVFILYGDLPQ-----------------RDIDMDMRHYLRTSTC 1228

  Fly  1094 ---QTPSMWQRLRTFCCGENRRRRKQRRQP----QQRRQRAYTAAAANPYQYQFAELRQQRQNRA 1151
               .....||:||......|.|....:|..    ..|.......|.::.||.....:......|.
  Fly  1229 IEWDDKKFWQKLRLALPLPNGRGNNNKRVVSGCLSGRTPSVNMYATSHEYQAGNGGVIPPPSARY 1293

  Fly  1152 SSISSENF-----CSSRSSSWRHGP-PSSAPVPPGNCSM------------------PLKMLEPH 1192
            :...|.|:     |::......:.| |:||......|..                  ..|.|| |
  Fly  1294 ADCGSNNYATINECAAAGGGRGYKPIPTSASAAAAACKFNTMNQLSKKQQRDLSVAGMAKTLE-H 1357

  Fly  1193 AHPHGHGRRRHS-------AWLITRKTSQDS---NLSSSRNDSSASATTASTSTFRLSRSSAGS- 1246
            .|.|.|...|.|       ::|.:...:.||   .....||:::.......|     ::.:||. 
  Fly  1358 QHHHNHQANRRSQHEYAVPSYLPSAAPAYDSVDYAKQQIRNNANCECVNLGT-----AKRAAGKN 1417

  Fly  1247 -STPLPSIIAHN 1257
             ::.|||..:.|
  Fly  1418 PASGLPSSFSSN 1429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 4/20 (20%)
LRR_RI 180..>383 CDD:238064 63/243 (26%)
leucine-rich repeat 183..204 CDD:275380 6/26 (23%)
LRR_8 203..263 CDD:290566 19/88 (22%)
leucine-rich repeat 205..228 CDD:275380 10/22 (45%)
leucine-rich repeat 229..252 CDD:275380 5/30 (17%)
LRR_8 252..311 CDD:290566 23/79 (29%)
leucine-rich repeat 253..276 CDD:275380 8/43 (19%)
leucine-rich repeat 277..300 CDD:275380 9/22 (41%)
LRR_8 299..359 CDD:290566 18/60 (30%)
leucine-rich repeat 301..324 CDD:275380 8/22 (36%)
leucine-rich repeat 325..348 CDD:275380 6/23 (26%)
LRR_RI 327..567 CDD:238064 74/261 (28%)
leucine-rich repeat 349..371 CDD:275380 8/26 (31%)
LRR_8 370..425 CDD:290566 19/63 (30%)
leucine-rich repeat 372..393 CDD:275380 7/27 (26%)
leucine-rich repeat 394..415 CDD:275380 7/20 (35%)
leucine-rich repeat 418..486 CDD:275380 20/70 (29%)
leucine-rich repeat 441..464 CDD:275378 6/22 (27%)
LRR_8 487..545 CDD:290566 20/57 (35%)
leucine-rich repeat 487..510 CDD:275380 9/22 (41%)
leucine-rich repeat 511..534 CDD:275380 5/22 (23%)
LRR_8 533..589 CDD:290566 17/62 (27%)
leucine-rich repeat 535..558 CDD:275380 8/22 (36%)
leucine-rich repeat 559..580 CDD:275380 5/27 (19%)
7tm_4 764..>892 CDD:304433 35/183 (19%)
7tm_1 770..1017 CDD:278431 67/354 (19%)
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 4/22 (18%)
LRR_8 171..236 CDD:290566 20/68 (29%)
leucine-rich repeat 172..201 CDD:275380 8/32 (25%)
leucine-rich repeat 202..278 CDD:275380 17/75 (23%)
leucine-rich repeat 229..249 CDD:275380 3/19 (16%)
LRR_RI 278..468 CDD:238064 57/197 (29%)
leucine-rich repeat 279..302 CDD:275380 6/22 (27%)
LRR_8 301..386 CDD:290566 27/84 (32%)
leucine-rich repeat 303..326 CDD:275380 9/22 (41%)
leucine-rich repeat 327..350 CDD:275380 8/22 (36%)
LRR 350..729 CDD:227223 107/449 (24%)
leucine-rich repeat 352..375 CDD:275380 6/22 (27%)
leucine-rich repeat 376..401 CDD:275380 8/26 (31%)
LRR_RI <401..626 CDD:238064 68/236 (29%)
leucine-rich repeat 402..425 CDD:275380 7/27 (26%)
leucine-rich repeat 426..449 CDD:275380 8/22 (36%)
leucine-rich repeat 450..473 CDD:275380 6/23 (26%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..518 CDD:275380 8/19 (42%)
leucine-rich repeat 521..544 CDD:275380 9/22 (41%)
leucine-rich repeat 545..566 CDD:275380 5/20 (25%)
leucine-rich repeat 569..592 CDD:275380 8/22 (36%)
leucine-rich repeat 593..615 CDD:275380 5/26 (19%)
leucine-rich repeat 616..637 CDD:275380 8/60 (13%)
leucine-rich repeat 638..662 CDD:275380 5/36 (14%)
leucine-rich repeat 663..684 CDD:275380 7/22 (32%)
leucine-rich repeat 685..708 CDD:275380 2/23 (9%)
leucine-rich repeat 709..728 CDD:275380 4/20 (20%)
LRR_8 883..943 CDD:290566 15/60 (25%)
leucine-rich repeat 885..908 CDD:275380 6/22 (27%)
leucine-rich repeat 909..932 CDD:275380 6/22 (27%)
LRR_8 932..990 CDD:290566 12/65 (18%)
leucine-rich repeat 933..956 CDD:275380 6/23 (26%)
TIR 1114..1247 CDD:214587 21/149 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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