DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and dnaaf11

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001032332.1	Gene:	dnaaf11 / 394985	XenbaseID:	XB-GENE-946667	Length:	470	Species:	Xenopus tropicalis

Alignment Length:	423	Identity:	90/423 - (21%)
Similarity:	153/423 - (36%)	Gaps:	141/423 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 LKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRAN---PLSTISPG 410
            ||:|.|.:|||..: |.:|||.:|:.|::..|.:..|.:.|...|:|.||:..|   .||:|:.
Frog    46 LKILYLQNNLIGKI-ENVSKLKKLEYLNLALNNIEKIENLEGCESLQKLDLTVNFVGDLSSINS- 108

  Fly   411 AFRGMSKLRKLILSDVRTLRSFPEL-EACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNS 474
                        |.:.|.||.|..: ..|...|..:      |.|.|.|    |:||.|:.|  .
Frog   109 ------------LQENRQLREFYLVGNPCAEYEGYR------QYVVATL----PQLKWLDGK--E 149

  Fly   475 LKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLD 539
            ::|...:.:.:|          ..::|||    :|:..:   :|.|.:|..::  :....||...
Frog   150 IERSERIQAAQD----------YPQVQGK----IKEQEE---AYLRKRAAERE--KATNNLQQKQ 195

  Fly   540 LEGNEISYIHKEAFSGFTA--LEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPR 602
            .||.:.    :|...||..  ..|:   ||..|:..|         ||            ||..:
Frog   196 KEGRKA----QEKKPGFDRRWYTDI---NNTIPDPVE---------KT------------DTVAQ 232

  Fly   603 IQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQL 667
            :                           .|.|..|...|.|.:...||.      |..:....:|
Frog   233 L---------------------------NVDETALRNDDEEEEKEFWNQ------PSQYTPESRL 264

  Fly   668 GAS--MHDPWETAINFNEEQLQTQTGGQIAT---------------SYMEEYFEEHDVSGPATGY 715
            ...  :.:..::..|.:||:|:.:....:.|               |.:::  ||::      .:
Frog   265 ETHRYLEEKRKSKENRSEEELKKKPPRTLITAEGRVLNVNESKLDFSLVDD--EENN------QF 321

  Fly   716 GFGTGLFSGMSTE----DFQPGSVQCLPMPGPF 744
            .....::..:.|.    |.|||.::.|....||
Frog   322 VLDLAIYRHLDTSLLDVDVQPGYIKVLVKEKPF 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	14/33 (42%)
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566	5/9 (56%)
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064	57/223 (26%)
		leucine-rich repeat	349..371	CDD:275380	11/21 (52%)
		LRR_8	370..425	CDD:290566	14/57 (25%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		leucine-rich repeat	394..415	CDD:275380	7/23 (30%)
		leucine-rich repeat	418..486	CDD:275380	17/68 (25%)
		leucine-rich repeat	441..464	CDD:275378	5/22 (23%)
		LRR_8	487..545	CDD:290566	11/57 (19%)
		leucine-rich repeat	487..510	CDD:275380	3/22 (14%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		LRR_8	533..589	CDD:290566	14/57 (25%)
		leucine-rich repeat	535..558	CDD:275380	7/22 (32%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
dnaaf11	NP_001032332.1	LRR_9	1..175	CDD:373143	46/171 (27%)
		LRR 1	20..43
		leucine-rich repeat	23..45	CDD:275378
		LRR 2	44..65		9/19 (47%)
		leucine-rich repeat	46..67	CDD:275378	11/21 (52%)
		LRR 3	66..89		5/22 (23%)
		leucine-rich repeat	68..89	CDD:275378	5/20 (25%)
		leucine-rich repeat	90..114	CDD:275378	8/36 (22%)
		LRR 4	90..110		7/32 (22%)
		PTZ00121	<148..>287	CDD:173412	39/220 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..265		24/145 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910