DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and caps

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster

Alignment Length:	619	Identity:	160/619 - (25%)
Similarity:	249/619 - (40%)	Gaps:	110/619 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 CRGIGILAVPVNLPNEVVVLDLGN--NNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLA 227
            |..:.:..|...||   |.|.|.|  |.   .|.:...:..|..|.|| |...|.::|
  Fly    22 CLCLCLCLVLATLP---VALGLANCPNG---CECDDDTLMVNCGEGTL-DVLPIALNP------- 72

  Fly   228 KLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPT 292
            .::||.::|..||:: ..|.|..||||.|.|:.|.::::......:..||:.|.|:.|...::..
  Fly    73 AIQRLVIKNNKLKTI-DSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQELHLDHNKIGQVSN 136

  Fly   293 NALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDN 357
            ....||.|:..|||..||:..:....|..|..|..|.|.:|:|..|...||..|..|:||.||||
  Fly   137 KTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRISHIDPHALDGLDNLRVLYLDDN 201

  Fly   358 LISSLPEGLS--KLSQLQELSITSNRLRWINDTELP--RSMQMLDMRANPLSTISPGAFRGMSKL 418
            .::::|..|:  .|..|.||.:.:|....|......  :.:..||:|...|..||..|.:|:..|
  Fly   202 TLTTVPGELTFQALHSLAELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSL 266

  Fly   419 RKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPN--L 481
            |.|.|||.|                       :..:|....::..||:.|.:..|..:.|.:  .
  Fly   267 RFLDLSDNR-----------------------LPAIPTAAFQRLGRLEQLNIGQNDFEVISSGAF 308

  Fly   482 SSCRDLRLLDLSSNQ-IEKIQGKPFNGLKQLNDLLLSYNR-IKALPQDAFQGIPKLQLLDLEGNE 544
            |..|:||.|:|:..| :.:::...|:|...|..|.||.|: :..|...|..|:|.|..:.|:.|:
  Fly   309 SGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQ 373

  Fly   545 ISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRA--LLHLKTFNNPKLREFPPPDTFP-RIQTL 606
            :|.: .|....:..|:.|:|..|.|    |...|.  |.||....|...:..|....:| .::.|
  Fly   374 LSSL-DEGLVPWADLQTLDLSENPF----ECDCRLLWLRHLLVSRNASGQYAPVICAYPTALRDL 433

  Fly   607 ILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASM 671
            .|::...     ||:..:....:.|....:|..:.|....||    .:.::...|.:.:.|..
  Fly   434 PLAHLAE-----PLLGCAHGAASKQAIIGILVVACAALITTL----ALVLYTCRHRIREMLKG-- 487

  Fly   672 HDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSG----PAT-GYGF-------------- 717
                .:|:...|.:.|       .|...|||.......|    ||. ||.:
  Fly   488 ----HSALGRKEREYQ-------KTFSDEEYMSRPPPGGGGVHPAAGGYPYIAGNSRMIPVTELX 541

  Fly   718 ----------GTGLFSGMSTEDFQPGSVQCLPMP 741
                      |.|...|.||..   |:||.|.:|
  Fly   542 LEAPPPPQLRGRGGGGGASTAS---GAVQQLQVP 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	3/13 (23%)
		LRR_RI	180..>383	CDD:238064	65/206 (32%)
		leucine-rich repeat	183..204	CDD:275380	5/22 (23%)
		LRR_8	203..263	CDD:290566	21/59 (36%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	18/58 (31%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	24/59 (41%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	9/22 (41%)
		LRR_RI	327..567	CDD:238064	70/247 (28%)
		leucine-rich repeat	349..371	CDD:275380	10/23 (43%)
		LRR_8	370..425	CDD:290566	17/56 (30%)
		leucine-rich repeat	372..393	CDD:275380	5/22 (23%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	14/69 (20%)
		leucine-rich repeat	441..464	CDD:275378	1/22 (5%)
		LRR_8	487..545	CDD:290566	19/59 (32%)
		leucine-rich repeat	487..510	CDD:275380	7/23 (30%)
		leucine-rich repeat	511..534	CDD:275380	8/23 (35%)
		LRR_8	533..589	CDD:290566	16/57 (28%)
		leucine-rich repeat	535..558	CDD:275380	5/22 (23%)
		leucine-rich repeat	559..580	CDD:275380	7/22 (32%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	7/21 (33%)
		LRR_8	96..155	CDD:290566	18/58 (31%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		LRR_8	143..201	CDD:290566	22/57 (39%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		LRR_RI	147..397	CDD:238064	79/273 (29%)
		leucine-rich repeat	169..192	CDD:275380	9/22 (41%)
		leucine-rich repeat	193..217	CDD:275380	10/23 (43%)
		LRR_8	217..276	CDD:290566	20/81 (25%)
		leucine-rich repeat	218..241	CDD:275380	5/22 (23%)
		leucine-rich repeat	242..265	CDD:275380	8/22 (36%)
		LRR_8	265..321	CDD:290566	19/78 (24%)
		leucine-rich repeat	266..289	CDD:275380	8/45 (18%)
		leucine-rich repeat	290..313	CDD:275380	5/22 (23%)
		LRR_8	312..374	CDD:290566	20/61 (33%)
		leucine-rich repeat	314..335	CDD:275380	6/20 (30%)
		leucine-rich repeat	339..363	CDD:275380	8/23 (35%)
		LRRCT	395..445	CDD:214507	14/58 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910