DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and chad

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_957357.1	Gene:	chad / 394038	ZFINID:	ZDB-GENE-040426-1130	Length:	363	Species:	Danio rerio

Alignment Length:	403	Identity:	103/403 - (25%)
Similarity:	163/403 - (40%)	Gaps:	96/403 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |||.|.|:  .:.|..:|:..:| .:.....:|:|..|||..|....|.....|..|.|....|.
Zfish    31 CHCHGDLQ--HVICDNVGLKKIP-RISEATRLLNLQRNNLGNLPTGGFSEMKGLISLHLQHCQIR 92

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            .:...||.||.||..|.|.:..:.::.|.:|:.|.:||.|.|:||.:.||
Zfish    93 ELSGQAFKGLNKLIYLYLSDNEISTIKPGAFEDLTELTYLYLDGNQITSL--------------- 142

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
                     |....:.:..|..|.|.:|.|..:....|....:|..|.:..|::..|..|:|..:
Zfish   143 ---------PKGIFSPMINLFILQLNNNKLRELQPGTFKGAKDLRWLYMSGNELSSIQPGSLDEV 198

  Fly   347 TALKVLELDDNLISSLP-EGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPG 410
            ..|.:|.||.|.:|:.| ..:|||..::||:::.                      ||||.|...
Zfish   199 ENLAILTLDQNNLSTYPLLAMSKLRVVEELNLSK----------------------NPLSLIPDH 241

  Fly   411 AFRGMSK-LRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNS 474
            |||...: :.||.|:|:             :||  |...|..:.|.|        ||||.|:.|.
Zfish   242 AFRSFGRYMEKLHLNDM-------------SLE--KFSNAAFEGVTA--------LKSLHLENNK 283

  Fly   475 LKRIPN---LSSCRDLRL-----------------LDLSSNQIEKIQGKPFNGL-KQLNDLLLSY 518
            |:.:||   .|:.:::.|                 :|.:.|:.:.:...|.|.. ||:.| ..::
Zfish   284 LRSLPNSLEFSTIQNITLFNNPWSCTCPLTNLRKWMDTTRNRPDAVCASPANQKGKQIRD-STAF 347

  Fly   519 NRIKALPQDAFQG 531
            .|.|...:.|.:|
Zfish   348 TRCKGKTKRARKG 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/20 (20%)
		LRR_RI	180..>383	CDD:238064	55/203 (27%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	21/59 (36%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	6/22 (27%)
		LRR_8	252..311	CDD:290566	13/58 (22%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	1/22 (5%)
		LRR_8	299..359	CDD:290566	17/59 (29%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	57/228 (25%)
		leucine-rich repeat	349..371	CDD:275380	10/22 (45%)
		LRR_8	370..425	CDD:290566	13/55 (24%)
		leucine-rich repeat	372..393	CDD:275380	2/20 (10%)
		leucine-rich repeat	394..415	CDD:275380	8/20 (40%)
		leucine-rich repeat	418..486	CDD:275380	20/70 (29%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	12/63 (19%)
		leucine-rich repeat	487..510	CDD:275380	5/40 (13%)
		leucine-rich repeat	511..534	CDD:275380	5/21 (24%)
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
chad	NP_957357.1	LRRNT	26..52	CDD:279764	8/23 (35%)
		leucine-rich repeat	57..80	CDD:275380	7/22 (32%)
		LRR_8	79..139	CDD:290566	21/59 (36%)
		leucine-rich repeat	81..104	CDD:275380	8/22 (36%)
		LRR_RI	<96..304	CDD:238064	73/276 (26%)
		LRR_4	104..143	CDD:289563	15/62 (24%)
		leucine-rich repeat	105..128	CDD:275380	6/22 (27%)
		LRR_8	127..187	CDD:290566	18/83 (22%)
		leucine-rich repeat	129..152	CDD:275380	9/46 (20%)
		leucine-rich repeat	153..176	CDD:275380	6/22 (27%)
		LRR_8	177..235	CDD:290566	19/79 (24%)
		leucine-rich repeat	177..200	CDD:275380	6/22 (27%)
		leucine-rich repeat	201..224	CDD:275380	10/22 (45%)
		LRR_8	225..284	CDD:290566	26/103 (25%)
		leucine-rich repeat	225..248	CDD:275380	10/44 (23%)
		leucine-rich repeat	250..273	CDD:275380	9/37 (24%)
		LRRCT	304..351	CDD:214507	8/47 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910