DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and lpar1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001004502.2	Gene:	lpar1 / 368461	ZFINID:	ZDB-GENE-030616-499	Length:	346	Species:	Danio rerio

Alignment Length:	314	Identity:	70/314 - (22%)
Similarity:	129/314 - (41%)	Gaps:	61/314 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   763 VFLLSLLGNGTVVFVLLCSRSKMDVP-RFLVCNLAAADFFMGI-YLGILAIVDAATLGEFRMFAI 825
            |.:..:|.|..|:..:..:| :...| .:|:.||||||||.|: |..::......|.   |:...
Zfish    41 VCIFIMLANLLVMVAIYINR-RFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTR---RLTVS 101

  Fly   826 PWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALI 890
            .|.:.     .|.:.. |...||..|..|.:||:..: ..:.|:.|:|.::...::.:.|..:::
Zfish   102 TWLLR-----QGLIDT-SLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVIIWTMSIV 159

  Fly   891 MALMPLVGVSDYRKFAVCLPFETTTGPASL---TYVISLMFINGCAFLTLMGCYLKMYWAIR--- 949
            |..:|.||.:     .:| ..:|.:..|.|   :|:......|...|:.::..|..::..:|
Zfish   160 MGAIPSVGWN-----CIC-AIDTCSNMAPLYSNSYLGFWAIFNLVTFVVMVVLYAHIFMYVRQRT 218

  Fly   950 -------GSQAWNTNDSRIAKRMALLVFTDFL-CWSPIAFFSITAIFGLQLISLEQA-------- 998
                   ..|..|.:......:..::|...|: ||:|          ||.::.|:..
Zfish   219 MRMSRHSSGQRRNRDTMMSLLKTVVIVLGAFIVCWTP----------GLVILLLDVVCANCNVLT 273

  Fly   999 -KIFTVFVLPLNSCCNPFLYAIMTKQ----FKKDCVTLCKHFEESRVVGGGGPG 1047
             :.|.:.:...||..||.:|:...|:    ||:   .||...:|:  |.|...|
Zfish   274 YEKFFLLLAEFNSAMNPIIYSYRDKEMSITFKQ---ILCCQRQEN--VNGTAEG 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	31/129 (24%)
		7tm_1	770..1017	CDD:278431	58/271 (21%)
lpar1	NP_001004502.2	7tm_1	49..293	CDD:278431	58/270 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910