DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Flrt3

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001119763.1	Gene:	Flrt3 / 366205	RGDID:	1566005	Length:	649	Species:	Rattus norvegicus

Alignment Length:	604	Identity:	134/604 - (22%)
Similarity:	207/604 - (34%)	Gaps:	216/604 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 KSASVTPTGIRENVMLPSADPEKEAQILYEKSLQEYHGSQLSTASTATDVIAGKRTLHSICERWL 148
            :|.:..|.||.|           :|..||   ||   .:|::.....:|:
  Rat    47 RSLTSIPVGIPE-----------DATTLY---LQ---NNQINNVGIPSDL--------------- 79

  Fly   149 QKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDN 213
                  ...|:|.|:......:...|.|||..|..|.|..||:..:..:|....|.||||.|.||
  Rat    80 ------KNLLKVQRIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDN 138

  Fly   214 SI--INMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQK 276
            |:  ::::..||.....|:.|.|....|.::|                            |.|.:
  Rat   139 SVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIP----------------------------GGLPR 175

  Fly   277 -LRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTI--INDEDFPRMPNLIVLLLKRNQIMKI 338
             :..|||:.|....|.:.:|.||.:|:.|.|..|||..  :.|:.|..:.||..|.|.||.:
  Rat   176 TIEELRLDDNRISTISSPSLHGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSL--- 237

  Fly   339 SAGALKNL--TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRA 401
             ..|..||  |:|:.|.|.||.|:.:|               .|...::      |.:..|||..
  Rat   238 -TAAPVNLPGTSLRKLYLQDNHINRVP---------------PNAFSYL------RQLYRLDMSN 280

  Fly   402 NPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPAN------LCR 460
            |.||.:..|.|..:..:.:||      ||:.|....|.    :|..|..:|.:|..      :|:
  Rat   281 NNLSNLPQGIFDDLDNITQLI------LRNNPWYCGCK----MKWVRDWLQSLPVKVNVRGLMCQ 335

  Fly   461 QTPRLKSLELKTNSLKRIPNLSSCRDLRLL----------------------------DLSSNQI 497
            ...:::.:.:|..|.:    |..|:|..::                            |:.:.::
  Rat   336 APEKVRGMAIKDLSAE----LFDCKDSGIVSTVQITTAIPNTAYPAQGQWPAPVTKQPDIKNPKL 396

  Fly   498 EKIQ---GKPFNGLKQLNDLLLSYNRIK----------ALPQDAFQGIPKLQLLDLEGNEISYIH 549
            .|.|   |.|     ....:|::...:.          |||..|.    :|..|.|.       |
  Rat   397 TKDQRTTGSP-----SRKTILITVKSVTPDTIHISWRLALPMTAL----RLSWLKLG-------H 445

  Fly   550 KEAFSGF--------------TALEDLNLGNNIFPELPESGLR-ALLHLKTFN------------ 587
            ..||...              ||||            |||..| .::.::|.|
  Rat   446 SPAFGSITETIVTGERSEYLVTALE------------PESPYRVCMVPMETSNLYLFDETPVCIE 498

  Fly   588 --NPKLREFPPPDTFPRIQ 604
              ...||.:.|..|..|.|
  Rat   499 TQTAPLRMYNPTTTLNREQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	58/209 (28%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	16/61 (26%)
		leucine-rich repeat	205..228	CDD:275380	10/24 (42%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_8	252..311	CDD:290566	14/59 (24%)
		leucine-rich repeat	253..276	CDD:275380	2/22 (9%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	23/63 (37%)
		leucine-rich repeat	301..324	CDD:275380	8/24 (33%)
		leucine-rich repeat	325..348	CDD:275380	8/24 (33%)
		LRR_RI	327..567	CDD:238064	61/302 (20%)
		leucine-rich repeat	349..371	CDD:275380	7/21 (33%)
		LRR_8	370..425	CDD:290566	12/54 (22%)
		leucine-rich repeat	372..393	CDD:275380	1/20 (5%)
		leucine-rich repeat	394..415	CDD:275380	8/20 (40%)
		leucine-rich repeat	418..486	CDD:275380	15/73 (21%)
		leucine-rich repeat	441..464	CDD:275378	5/28 (18%)
		LRR_8	487..545	CDD:290566	13/98 (13%)
		leucine-rich repeat	487..510	CDD:275380	5/53 (9%)
		leucine-rich repeat	511..534	CDD:275380	5/32 (16%)
		LRR_8	533..589	CDD:290566	16/84 (19%)
		leucine-rich repeat	535..558	CDD:275380	6/36 (17%)
		leucine-rich repeat	559..580	CDD:275380	6/21 (29%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Flrt3	NP_001119763.1	LRRNT	31..61	CDD:214470	5/24 (21%)
		Interaction with ADGRL3. /evidence=ECO:0000250\|UniProtKB:Q9NZU0	38..67		10/36 (28%)
		LRR 1. /evidence=ECO:0000255	59..80		7/47 (15%)
		LRR_4	61..100	CDD:289563	9/65 (14%)
		leucine-rich repeat	61..84	CDD:275378	6/49 (12%)
		LRR 2. /evidence=ECO:0000255	84..104		5/19 (26%)
		leucine-rich repeat	85..104	CDD:275380	5/18 (28%)
		LRR 3. /evidence=ECO:0000255	105..126		6/20 (30%)
		LRR_8	106..166	CDD:290566	20/59 (34%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_RI	109..327	CDD:238064	76/280 (27%)
		LRR 4. /evidence=ECO:0000255	129..150		8/20 (40%)
		leucine-rich repeat	130..155	CDD:275380	10/24 (42%)
		LRR 5. /evidence=ECO:0000255	155..176		7/48 (15%)
		leucine-rich repeat	156..176	CDD:275380	7/47 (15%)
		LRR_8	175..237	CDD:290566	22/61 (36%)
		leucine-rich repeat	177..200	CDD:275380	8/22 (36%)
		LRR 6. /evidence=ECO:0000255	177..197		6/19 (32%)
		LRR 7. /evidence=ECO:0000255	200..220		7/19 (37%)
		leucine-rich repeat	201..226	CDD:275380	8/24 (33%)
		LRR 8. /evidence=ECO:0000255	226..247		9/24 (38%)
		leucine-rich repeat	227..248	CDD:275380	8/24 (33%)
		LRR_8	247..306	CDD:290566	22/85 (26%)
		LRR 9. /evidence=ECO:0000255	248..269		8/35 (23%)
		leucine-rich repeat	249..272	CDD:275380	8/43 (19%)
		LRR 10. /evidence=ECO:0000255	272..293		8/20 (40%)
		leucine-rich repeat	273..296	CDD:275380	8/22 (36%)
		LRRCT	305..356	CDD:214507	10/58 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..405		3/26 (12%)
		fn3	413..478	CDD:278470	18/87 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910