DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Scrib

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001178808.1	Gene:	Scrib / 362938	RGDID:	1565055	Length:	1663	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	130/479 - (27%)
Similarity:	192/479 - (40%)	Gaps:	108/479 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 CERWLQ----KHCHCTGSLEVLRLSCRGIGILAVPVNLPNEV---------VVLDLGNNNLTKLE 195
            |.|.::    :||    ||:|                :|.|:         ::||.  |.|.:|
  Rat    10 CNRHVESVDKRHC----SLQV----------------VPEEIYRYSRSLEELLLDA--NQLREL- 51

  Fly   196 ANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLP----------------- 243
            ...||...||.:|.||||.|..:.|.. ....:|..|.:....:..:|
  Rat    52 PKPFFRLLNLRKLGLSDNEIQRLPPEV-ANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGN 115

  Fly   244 -----PQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEA 303
                 |..|..|..|..|.||..:|.:|.|| :|:|..|.||.|..||...:|. :|:.|..||.
  Rat   116 PLSRLPDGFTQLRSLAHLALNDVSLQALPGD-VGNLANLVTLELRENLLKSLPA-SLSFLVKLEQ 178

  Fly   304 LNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKI--SAGALKNLTALKVLE------------- 353
            |:||.|.|.::.| ....:|||..|.|.|||:..:  ..|.|:.|..|.|.|
  Rat   179 LDLGGNDLEVLPD-TLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPVELGGL 242

  Fly   354 -------LDDNLISSLPEGLSKLSQLQELSITSNRL----RWINDTELPRSMQMLDMRANPLSTI 407
                   |..||:..||||:.:|.||..|.:..|||    ..|.|.|   ::..|.:..|.|:.:
  Rat   243 ALLTDLLLSQNLLQRLPEGIGQLKQLSILKVDQNRLCEVTEAIGDCE---NLSELILTENLLTAL 304

  Fly   408 SPGAFRGMSKLRKLILSDVRTLRSF-----PELEACHALEILKLDRAGIQEVPANLCRQTPRLKS 467
            .    |.:.||.|  |:::...|:.     ||:..|.||.:|.|....:..:|..|. .|..|..
  Rat   305 P----RSLGKLTK--LTNLNVDRNHLEVLPPEIGGCVALSVLSLRDNRLAVLPPELA-HTAELHV 362

  Fly   468 LELKTNSLKRIPNLSSCRDLRLLDLSSNQIE-----KIQGKPFNGLKQLNDLLLSYNRIKALPQD 527
            |::..|.|:.:|...:..:|:.|.|:.||.:     :.:.....|.|.|...||....:.:|...
  Rat   363 LDVAGNRLRSLPFALTHLNLKALWLAENQAQPMLRFQTEDDAQTGEKVLTCYLLPQQPLPSLEDP 427

  Fly   528 AFQGIPKLQLLDLEGNEISYIHKE 551
            ..|..|.....|...:.:|.|..|
  Rat   428 GQQSSPSESCSDAPLSRVSVIQFE 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	2/20 (10%)
		LRR_RI	180..>383	CDD:238064	78/259 (30%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	19/81 (23%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	6/44 (14%)
		LRR_8	252..311	CDD:290566	25/58 (43%)
		leucine-rich repeat	253..276	CDD:275380	10/22 (45%)
		leucine-rich repeat	277..300	CDD:275380	9/22 (41%)
		LRR_8	299..359	CDD:290566	24/81 (30%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	9/24 (38%)
		LRR_RI	327..567	CDD:238064	69/261 (26%)
		leucine-rich repeat	349..371	CDD:275380	11/41 (27%)
		LRR_8	370..425	CDD:290566	17/58 (29%)
		leucine-rich repeat	372..393	CDD:275380	8/24 (33%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	19/72 (26%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	14/62 (23%)
		leucine-rich repeat	487..510	CDD:275380	6/27 (22%)
		leucine-rich repeat	511..534	CDD:275380	5/22 (23%)
		LRR_8	533..589	CDD:290566	5/19 (26%)
		leucine-rich repeat	535..558	CDD:275380	4/17 (24%)
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Scrib	NP_001178808.1	LRR_RI	12..232	CDD:238064	71/246 (29%)
		leucine-rich repeat	14..37	CDD:275380	7/42 (17%)
		leucine-rich repeat	38..60	CDD:275380	7/24 (29%)
		LRR	39..405	CDD:227223	109/382 (29%)
		leucine-rich repeat	61..83	CDD:275380	8/22 (36%)
		leucine-rich repeat	84..106	CDD:275380	3/21 (14%)
		leucine-rich repeat	107..129	CDD:275380	3/21 (14%)
		leucine-rich repeat	130..152	CDD:275380	10/22 (45%)
		leucine-rich repeat	153..175	CDD:275380	9/22 (41%)
		leucine-rich repeat	176..198	CDD:275380	8/22 (36%)
		leucine-rich repeat	199..221	CDD:275380	8/21 (38%)
		leucine-rich repeat	268..290	CDD:275380	8/24 (33%)
		LRR_4	289..329	CDD:289563	10/48 (21%)
		leucine-rich repeat	291..313	CDD:275380	6/25 (24%)
		leucine-rich repeat	314..336	CDD:275380	5/21 (24%)
		leucine-rich repeat	360..381	CDD:275380	5/20 (25%)
		PDZ	709..797	CDD:214570
		PDZ_signaling	852..931	CDD:238492
		PDZ_signaling	986..1074	CDD:238492
		PDZ_signaling	1083..1173	CDD:238492
		AbLIM_anchor	1563..>1657	CDD:292800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910