DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Tlr12

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001102152.1	Gene:	Tlr12 / 362604	RGDID:	1559145	Length:	904	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	126/475 - (26%)
Similarity:	196/475 - (41%)	Gaps:	93/475 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 NNLTK-LEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQ 252
            :|||: |||    :..|:|.|.|| .|:..:.|:||.....||.|.| |..|..|.|.:.:||.|
  Rat    58 SNLTQTLEA----VPRNVEGLCLS-GSVSTLLPDAFSAFPGLKFLGL-NLHLTRLLPGALRGLGQ 116

  Fly   253 LTSL----QLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTI 313
            |.:|    |.:|...:.|..|..|.|..|:.|...|...     |..||:|...:|...|..::.
  Rat   117 LRNLSFVDQPSGKNSLFLPPDAFGDLISLQRLHFCGPCL-----NKKAGVRLPSSLQWLSVTISC 176

  Fly   314 INDED-----FPRMP---------NLIVLLLKRNQIMKISA-GALKNLTA----LKVLELDDNLI 359
            :.|..     ||.:.         .|..|.|..||.:|::. |:|:.|..    |:..:||...:
  Rat   177 LQDSGELAGIFPDLVQNSSSRASWTLKKLDLSLNQKLKMATPGSLQGLQVEILDLRKTQLDAGAV 241

  Fly   360 SSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILS 424
            ..|  ||.||:.|...:.|:....   :|.....:|.|::..:.:..||..|
  Rat   242 KGL--GLQKLNVLYAPTATAELAA---ETAAHFELQGLNVDRSKIGNISQEA------------- 288

  Fly   425 DVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKR----IPNLSSCR 485
                      |.:||:||.|.|...|:.::|.......|||:.|.|..|.|:.    :.......
  Rat   289 ----------LASCHSLETLSLSDTGLTKLPPGFLAAMPRLRRLNLAGNQLQSTMLCMNETGDVS 343

  Fly   486 DLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHK 550
            .|..||||.|.:..:....|:.|..|.:|||..|::.:|....||.:.:|:.|.|:.|.:..:.|
  Rat   344 GLSTLDLSGNGLRILPPATFSCLPHLRELLLQDNQLLSLEGHPFQDLQQLETLKLDRNPLLNLGK 408

  Fly   551 EAFSGFTALEDLNLGNNIFPELPESGL---RAL--LHLK--TFNNPKLREFP------------- 595
            ...:...||..|:|.:......|::|.   |:|  |||.  ..:.|.:...|
  Rat   409 NCLAALPALTTLSLLDTQILHSPDAGFWGARSLHTLHLSLPPLSAPAVLSLPMYLTSLELHVTPG 473

  Fly   596 ------PPDTFPRIQTLILS 609
                  .|:.||.::||.::
  Rat   474 LKHWTLSPNIFPFLETLTIN 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	65/217 (30%)
		leucine-rich repeat	183..204	CDD:275380	6/15 (40%)
		LRR_8	203..263	CDD:290566	24/63 (38%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	10/22 (45%)
		LRR_8	252..311	CDD:290566	18/62 (29%)
		leucine-rich repeat	253..276	CDD:275380	8/26 (31%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	18/78 (23%)
		leucine-rich repeat	301..324	CDD:275380	5/36 (14%)
		leucine-rich repeat	325..348	CDD:275380	9/23 (39%)
		LRR_RI	327..567	CDD:238064	65/248 (26%)
		leucine-rich repeat	349..371	CDD:275380	8/21 (38%)
		LRR_8	370..425	CDD:290566	8/54 (15%)
		leucine-rich repeat	372..393	CDD:275380	3/20 (15%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	16/71 (23%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	20/57 (35%)
		leucine-rich repeat	487..510	CDD:275380	8/22 (36%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	16/62 (26%)
		leucine-rich repeat	535..558	CDD:275380	5/22 (23%)
		leucine-rich repeat	559..580	CDD:275380	6/23 (26%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Tlr12	NP_001102152.1	leucine-rich repeat	71..93	CDD:275380	8/22 (36%)
		leucine-rich repeat	94..116	CDD:275380	10/22 (45%)
		leucine-rich repeat	117..144	CDD:275380	8/26 (31%)
		leucine-rich repeat	202..225	CDD:275380	8/22 (36%)
		leucine-rich repeat	226..270	CDD:275380	11/48 (23%)
		leucine-rich repeat	246..259	CDD:275381	4/12 (33%)
		LRR_8	270..329	CDD:290566	20/81 (25%)
		leucine-rich repeat	271..294	CDD:275380	7/45 (16%)
		LRR_4	294..331	CDD:289563	13/36 (36%)
		leucine-rich repeat	295..318	CDD:275380	6/22 (27%)
		leucine-rich repeat	319..344	CDD:275380	5/24 (21%)
		LRR_8	343..403	CDD:290566	20/59 (34%)
		LRR_RI	345..547	CDD:238064	39/149 (26%)
		leucine-rich repeat	345..368	CDD:275380	8/22 (36%)
		leucine-rich repeat	369..392	CDD:275380	8/22 (36%)
		leucine-rich repeat	393..416	CDD:275380	5/22 (23%)
		leucine-rich repeat	417..437	CDD:275380	5/19 (26%)
		leucine-rich repeat	441..510	CDD:275380	11/53 (21%)
		leucine-rich repeat	511..562	CDD:275380
		leucine-rich repeat	563..591	CDD:275380
		leucine-rich repeat	592..615	CDD:275380
		TIR	759..900	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910