DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Tril

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001029182.1	Gene:	Tril / 362364	RGDID:	1310827	Length:	811	Species:	Rattus norvegicus

Alignment Length:	414	Identity:	116/414 - (28%)
Similarity:	170/414 - (41%)	Gaps:	91/414 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 SICERWLQKHCHCTGSLEVLRLSCRGIGILAVP----VNLPNEVVVLDLGNNNLTKLEANSFFMA 202
            |:|    .:.|.|.....:|   |...|:.|||    :..|.:|:...||.|.:|.:.|..
  Rat    25 SVC----PERCDCQHPQHLL---CTNRGLRAVPKTSSLPSPQDVLTYSLGGNFITNITAFD---- 78

  Fly   203 PNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLD 267
                                |:.|.:|:||.||...::||.|::|:.|::|..|.|..|.|.:|.
  Rat    79 --------------------FHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALA 123

  Fly   268 GDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKR 332
            ...|..|:|||.|...||...|:...:..||.:|..|.|..|:|..:.|..|..:.||:.|.|:.
  Rat   124 PGTLAPLRKLRILYANGNEIGRLSRGSFEGLESLVKLRLDGNVLGALPDAVFAPLGNLLYLHLEA 188

  Fly   333 NQIMKISAGALKNLTALKVLELDDN-LISSLPEGLS--KLSQLQELSITSNRLRWIND---TELP 391
            |:|..:...|...|..|:.|.|..| |..||....:  .|..|..|.:::|.|:.:..   ..||
  Rat   189 NRIRFLGKNAFTQLGKLRFLNLSANELQPSLRHAATFVPLRSLSTLILSANSLQHLGPRVFQHLP 253

  Fly   392 RSMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFP--ELEACHALEILKLDRAGIQEV 454
            | :.:|.:..|.|:.::|.||.|:..||:|.|...| |...|  .||..|:||
  Rat   254 R-LGLLSLSGNQLTHLAPEAFWGLEALRELRLEGNR-LNQLPLTLLEPLHSLE------------ 304

  Fly   455 PANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYN 519
                                              .||||.|::..:....|....:|.:|.|..|
  Rat   305 ----------------------------------ALDLSGNELSALHPATFGHQGRLRELSLRDN 335

  Fly   520 RIKALPQDAFQGIPKLQLLDLEGN 543
            .:.||..|.|...|.|..|||:||
  Rat   336 ALSALSGDIFAASPALYRLDLDGN 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/24 (25%)
		LRR_RI	180..>383	CDD:238064	61/205 (30%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	16/59 (27%)
		leucine-rich repeat	205..228	CDD:275380	2/22 (9%)
		leucine-rich repeat	229..252	CDD:275380	10/22 (45%)
		LRR_8	252..311	CDD:290566	21/58 (36%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	19/60 (32%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	61/225 (27%)
		leucine-rich repeat	349..371	CDD:275380	8/24 (33%)
		LRR_8	370..425	CDD:290566	18/57 (32%)
		leucine-rich repeat	372..393	CDD:275380	6/23 (26%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	12/69 (17%)
		leucine-rich repeat	441..464	CDD:275378	2/22 (9%)
		LRR_8	487..545	CDD:290566	21/57 (37%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	7/11 (64%)
		leucine-rich repeat	535..558	CDD:275380	6/9 (67%)
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Tril	NP_001029182.1	LRR_RI	22..313	CDD:238064	100/366 (27%)
		leucine-rich repeat	37..57	CDD:275378	6/22 (27%)
		LRR 1	61..81		7/43 (16%)
		LRR_8	84..143	CDD:290566	24/58 (41%)
		LRR 2	84..105		9/20 (45%)
		leucine-rich repeat	85..108	CDD:275380	10/22 (45%)
		LRR 3	108..129		7/20 (35%)
		leucine-rich repeat	109..132	CDD:275380	8/22 (36%)
		LRR 4	132..153		7/20 (35%)
		leucine-rich repeat	133..156	CDD:275380	8/22 (36%)
		LRR_8	156..215	CDD:290566	19/58 (33%)
		LRR 5	156..177		7/20 (35%)
		leucine-rich repeat	157..180	CDD:275380	7/22 (32%)
		LRR 6	180..201		7/20 (35%)
		leucine-rich repeat	181..204	CDD:275380	7/22 (32%)
		LRR 7	204..223		7/18 (39%)
		leucine-rich repeat	205..230	CDD:275380	8/24 (33%)
		LRR_8	229..289	CDD:290566	19/61 (31%)
		LRR 8	230..251		4/20 (20%)
		leucine-rich repeat	231..254	CDD:275380	5/22 (23%)
		LRR 9	254..275		7/21 (33%)
		leucine-rich repeat	255..278	CDD:275380	7/22 (32%)
		LRR 10	278..298		7/20 (35%)
		leucine-rich repeat	279..302	CDD:275380	9/23 (39%)
		LRR_8	302..359	CDD:290566	21/102 (21%)
		LRR 11	302..323		8/66 (12%)
		leucine-rich repeat	303..323	CDD:275380	8/65 (12%)
		LRR 12	326..347		8/20 (40%)
		leucine-rich repeat	327..340	CDD:275378	4/12 (33%)
		leucine-rich repeat	351..363	CDD:275378	6/9 (67%)
		TPKR_C2	359..406	CDD:301599	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..460
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..562
		FN3	589..661	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910