DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and LRRTM1

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_849161.2 Gene:LRRTM1 / 347730 HGNCID:19408 Length:522 Species:Homo sapiens


Alignment Length:275 Identity:73/275 - (26%)
Similarity:128/275 - (46%) Gaps:7/275 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|.|.|    |.|..:.:...|.|| :.::.|.|..|:|::|.|..|.....|..|.|..|.|.
Human    43 CRCEGRL----LYCEALNLTEAPHNL-SGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNHIC 102

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
            ::..:||..|.::|.|:|.:..:..||..:|:.:..|.|:.|:.|.|.:|..|....|:||.||.
Human   103 SVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLH 167

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            :..|....:|.......|:|:.|::|.|.|..:....|..:..|..|.|:.|.::|::......|
Human   168 MRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRL 232

  Fly   347 TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWIND--TELPRSMQMLDMRANPLSTISP 409
            .:|..|.|..|.::.:...|..:..|:::.::.|.:.::..  .|....:|.|.:.:|.|:.|.|
Human   233 ISLHSLCLRRNKVAIVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEP 297

  Fly   410 GAFRGMSKLRKLILS 424
            ........|..:.|:
Human   298 RILNSWKSLTSITLA 312

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 6/20 (30%)
LRR_RI 180..>383 CDD:238064 55/202 (27%)
leucine-rich repeat 183..204 CDD:275380 7/20 (35%)
LRR_8 203..263 CDD:290566 18/59 (31%)
leucine-rich repeat 205..228 CDD:275380 8/22 (36%)
leucine-rich repeat 229..252 CDD:275380 6/22 (27%)
LRR_8 252..311 CDD:290566 19/58 (33%)
leucine-rich repeat 253..276 CDD:275380 8/22 (36%)
leucine-rich repeat 277..300 CDD:275380 5/22 (23%)
LRR_8 299..359 CDD:290566 17/59 (29%)
leucine-rich repeat 301..324 CDD:275380 6/22 (27%)
leucine-rich repeat 325..348 CDD:275380 6/22 (27%)
LRR_RI 327..567 CDD:238064 21/100 (21%)
leucine-rich repeat 349..371 CDD:275380 5/21 (24%)
LRR_8 370..425 CDD:290566 11/57 (19%)
leucine-rich repeat 372..393 CDD:275380 3/22 (14%)
leucine-rich repeat 394..415 CDD:275380 6/20 (30%)
leucine-rich repeat 418..486 CDD:275380 2/7 (29%)
leucine-rich repeat 441..464 CDD:275378
LRR_8 487..545 CDD:290566
leucine-rich repeat 487..510 CDD:275380
leucine-rich repeat 511..534 CDD:275380
LRR_8 533..589 CDD:290566
leucine-rich repeat 535..558 CDD:275380
leucine-rich repeat 559..580 CDD:275380
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
LRRTM1NP_849161.2 LRR 1 64..87 8/23 (35%)
LRR_8 73..125 CDD:290566 16/51 (31%)
LRR_RI <85..268 CDD:238064 49/182 (27%)
LRR 2 89..111 7/21 (33%)
leucine-rich repeat 91..114 CDD:275380 8/22 (36%)
LRR 3 112..135 7/22 (32%)
LRR_8 113..173 CDD:290566 19/59 (32%)
leucine-rich repeat 115..138 CDD:275380 6/22 (27%)
LRR 4 137..159 7/21 (33%)
leucine-rich repeat 139..162 CDD:275380 8/22 (36%)
LRR_8 161..221 CDD:290566 17/59 (29%)
LRR 5 161..183 6/21 (29%)
leucine-rich repeat 163..186 CDD:275380 5/22 (23%)
LRR 6 184..207 7/22 (32%)
leucine-rich repeat 187..210 CDD:275380 6/22 (27%)
LRR 7 209..231 5/21 (24%)
leucine-rich repeat 211..234 CDD:275380 6/22 (27%)
LRR 8 233..255 5/21 (24%)
leucine-rich repeat 235..257 CDD:275380 5/21 (24%)
LRR 9 256..278 2/21 (10%)
LRR_8 257..315 CDD:290566 11/56 (20%)
LRR_4 257..297 CDD:289563 8/39 (21%)
leucine-rich repeat 258..281 CDD:275380 3/22 (14%)
LRR 10 279..302 6/22 (27%)
leucine-rich repeat 282..300 CDD:275380 6/17 (35%)
leucine-rich repeat 306..318 CDD:275378 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..401
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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