DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and CG16974

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster

Alignment Length:	609	Identity:	143/609 - (23%)
Similarity:	227/609 - (37%)	Gaps:	177/609 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 HCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMA------------P 203
            |...||:  |.:|:|..:.:..|     |:    :|.:...:.:..|...:|            |
  Fly   118 HVDPTGN--VFKLNCEHVDLRRV-----NQ----ELLSQRSSHINYNQLMLAHVPADRSNPLKLP 171

  Fly   204 NLEEL--------TLSDNSIINM---DPNAFYGLAKL----KRLS-------------------- 233
            .||.|        .|.|.:::.:   .|.:|..:.:|    .||.
  Fly   172 QLESLREFSWQSSELKDETLMELFTRQPRSFEYMERLNLAENRLECLHWAIPLAVRRVKVLEMSG 236

  Fly   234 --LQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALA 296
              |.||.|.:|     |.:.||..|.|:.:.|..|....||.|.:||.|.|..||...:|.:...
  Fly   237 NRLSNCSLLNL-----QYMKQLQELHLDRSELTYLPQRFLGELSELRMLNLSQNLLTELPRDIFV 296

  Fly   297 GLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISS 361
            |...||.|.|..|.|:::     |.|                   ..:....|:||:|.||.:.|
  Fly   297 GALKLERLYLSGNRLSVL-----PFM-------------------LFQTAADLQVLDLSDNRLLS 337

  Fly   362 LPEG-LSKLSQLQELSITSNRLRWINDTEL--PRSMQMLDMRANPLSTISPGAFRGMSKLRKLIL 423
            .|:. .::..||::|.:..|:|:.|....|  .|.::.||:..|.||.|...||..:..|..|.:
  Fly   338 FPDNFFARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKAFESLDHLLALNV 402

  Fly   424 S-DVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDL 487
            | :..||.|....::.|||..|.|.|...:::|:.|.::...|..|.:....:::..|..|..|.
  Fly   403 SGNNLTLLSSIIFQSLHALRQLDLSRNQFKQLPSGLFQRQRSLVLLRIDETPIEQFSNWISRYDE 467

  Fly   488 RLLD---------LSSNQIEKIQGKP---FNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDL 540
            .|:|         ||..|..|:...|   |.....:.:|||:.|.:..||.. ..|:.:||.|.:
  Fly   468 SLVDPQVLHRLRYLSVQQNRKLTYLPATLFANTPNIRELLLAENGLLQLPTQ-ISGLSRLQRLSV 531

  Fly   541 EGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQT 605
            .||                   :||:     |||: ::.|..|...|
  Fly   532 RGN-------------------SLGS-----LPEN-IKELRQLHYLN------------------ 553

  Fly   606 LILSYAYHC-CAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGA 669
             ||...|.| |:...|.|..:...|                      |:.:..||..|.|.  |:
  Fly   554 -ILGNEYQCDCSMYWLTAWLANTST----------------------SLRHQMPQAQNHSN--GS 593

  Fly   670 SMHDPWET--AINFNEEQLQTQTG 691
            :...|.::  :|:...:.|:.|.|
  Fly   594 TNQTPLDSYESIDHQIDALKCQYG 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/20 (20%)
		LRR_RI	180..>383	CDD:238064	57/252 (23%)
		leucine-rich repeat	183..204	CDD:275380	3/32 (9%)
		LRR_8	203..263	CDD:290566	21/96 (22%)
		leucine-rich repeat	205..228	CDD:275380	7/33 (21%)
		leucine-rich repeat	229..252	CDD:275380	9/48 (19%)
		LRR_8	252..311	CDD:290566	22/58 (38%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	14/59 (24%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	0/22 (0%)
		LRR_RI	327..567	CDD:238064	65/255 (25%)
		leucine-rich repeat	349..371	CDD:275380	8/22 (36%)
		LRR_8	370..425	CDD:290566	19/57 (33%)
		leucine-rich repeat	372..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..415	CDD:275380	8/20 (40%)
		leucine-rich repeat	418..486	CDD:275380	18/68 (26%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	20/69 (29%)
		leucine-rich repeat	487..510	CDD:275380	8/34 (24%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	13/55 (24%)
		leucine-rich repeat	535..558	CDD:275380	5/22 (23%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380	3/21 (14%)
		leucine-rich repeat	229..252	CDD:275380	6/27 (22%)
		LRR_RI	<246..433	CDD:238064	63/215 (29%)
		LRR_8	251..311	CDD:290566	22/59 (37%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		leucine-rich repeat	301..324	CDD:275380	8/46 (17%)
		LRR_8	325..383	CDD:290566	19/57 (33%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		LRR_RI	351..>557	CDD:238064	63/250 (25%)
		LRR_8	371..431	CDD:290566	21/59 (36%)
		leucine-rich repeat	373..396	CDD:275380	8/22 (36%)
		leucine-rich repeat	397..420	CDD:275380	6/22 (27%)
		leucine-rich repeat	421..444	CDD:275380	6/22 (27%)
		LRR_8	477..536	CDD:290566	18/78 (23%)
		leucine-rich repeat	478..502	CDD:275380	6/23 (26%)
		leucine-rich repeat	503..526	CDD:275380	7/23 (30%)
		Ig	<714..761	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910