DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and LRRIQ4

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001073929.1	Gene:	LRRIQ4 / 344657	HGNCID:	34298	Length:	560	Species:	Homo sapiens

Alignment Length:	488	Identity:	133/488 - (27%)
Similarity:	215/488 - (44%)	Gaps:	85/488 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 PVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCG 238
            |.::.:....:|..|.:||.:.. ..|....|||:.|.:|.|..: |.....|..::.|.|....
Human    20 PQHVNDRTFFIDASNQSLTAIPL-EIFTFTELEEVHLENNQIEEI-PQEIQRLKNIRVLYLDKNN 82

  Fly   239 LKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEA 303
            |:||.| :...|:.|.||.|:.|.:.|.....:..|..||.|||.......||......|..||.
Human    83 LRSLCP-ALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLEL 146

  Fly   304 LNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSK 368
            |.|..|.|..: .::......|..:.||||| .::....|..|..|::::||:|.|.::||.:..
Human   147 LGLTGNHLKCL-PKEIVNQTKLREIYLKRNQ-FEVFPQELCVLYTLEIIDLDENKIGAIPEEIGH 209

  Fly   369 LSQLQELSITSNRLRWINDTELPRS------MQMLDMRANPLSTISPGAFRGMSKLRKLILSDVR 427
            |:.||:..:.||.|     ..||.|      :.:||:..|.|.:| |.:|..:.|:.::.||..|
Human   210 LTGLQKFYMASNNL-----PVLPASLCQCSQLSVLDLSHNLLHSI-PKSFAELRKMTEIGLSGNR 268

  Fly   428 TLRSFPELEACH--ALEILKLDRAGIQEV-----------------------PANLCRQTPRLKS 467
             |...|.| .|.  :|.:|.|...|:..:                       |..:|    .||:
Human   269 -LEKVPRL-ICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQIC----ALKN 327

  Fly   468 LE---LKTNSLKRIPN-LSSCRDLRLLDLSSNQ-------------IEKI-----QG-------K 503
            ||   |..|.:.::|: |.|...|::|.|:.|:             :||:     ||       :
Human   328 LEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE 392

  Fly   504 PFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNI 568
            ....|:.|.:|.:..|.::.||. :...:|.|::||...|.:..: .:|.....||::|.|.:|:
Human   393 HIRKLQSLKELYIENNHLEYLPV-SLGSMPNLEVLDCRHNLLKQL-PDAICQAQALKELRLEDNL 455

  Fly   569 FPELPESGLRALLHLKT---FNNPKLREFPPPD 598
            ...|||: |.:|::||.   .:||  .|.||.:
Human   456 LTHLPEN-LDSLVNLKVLTLMDNP--MEEPPKE 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	1/4 (25%)
		LRR_RI	180..>383	CDD:238064	61/202 (30%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	20/59 (34%)
		leucine-rich repeat	205..228	CDD:275380	8/22 (36%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	20/58 (34%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	18/59 (31%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		LRR_RI	327..567	CDD:238064	77/299 (26%)
		leucine-rich repeat	349..371	CDD:275380	8/21 (38%)
		LRR_8	370..425	CDD:290566	17/60 (28%)
		leucine-rich repeat	372..393	CDD:275380	7/20 (35%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	22/96 (23%)
		leucine-rich repeat	441..464	CDD:275378	6/45 (13%)
		LRR_8	487..545	CDD:290566	19/82 (23%)
		leucine-rich repeat	487..510	CDD:275380	9/47 (19%)
		leucine-rich repeat	511..534	CDD:275380	5/22 (23%)
		LRR_8	533..589	CDD:290566	18/58 (31%)
		leucine-rich repeat	535..558	CDD:275380	5/22 (23%)
		leucine-rich repeat	559..580	CDD:275380	8/20 (40%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
LRRIQ4	NP_001073929.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		133/488 (27%)
		LRR 1	23..47		5/24 (21%)
		LRR 2	48..70		7/22 (32%)
		leucine-rich repeat	50..72	CDD:275380	8/22 (36%)
		LRR 3	72..95		7/23 (30%)
		leucine-rich repeat	73..119	CDD:275380	14/46 (30%)
		LRR 4	97..116		5/18 (28%)
		LRR_RI	117..360	CDD:238064	72/256 (28%)
		LRR 5	117..140		8/22 (36%)
		LRR_8	120..177	CDD:290566	20/58 (34%)
		leucine-rich repeat	120..143	CDD:275380	8/22 (36%)
		LRR 6	141..164		7/23 (30%)
		leucine-rich repeat	144..166	CDD:275380	6/22 (27%)
		LRR 7	166..187		7/21 (33%)
		leucine-rich repeat	167..189	CDD:275380	8/22 (36%)
		LRR 8	188..210		7/21 (33%)
		LRR_8	189..246	CDD:290566	19/61 (31%)
		leucine-rich repeat	190..212	CDD:275380	8/21 (38%)
		LRR 9	212..233		8/25 (32%)
		leucine-rich repeat	213..235	CDD:275380	8/26 (31%)
		LRR_8	234..315	CDD:290566	19/83 (23%)
		LRR 10	234..256		7/22 (32%)
		leucine-rich repeat	236..258	CDD:275380	7/22 (32%)
		LRR_RI	253..501	CDD:238064	61/244 (25%)
		LRR 11	258..281		8/24 (33%)
		leucine-rich repeat	259..304	CDD:275380	11/46 (24%)
		LRR 12	283..301		3/17 (18%)
		LRR 13	302..325		2/26 (8%)
		leucine-rich repeat	305..327	CDD:275380	3/25 (12%)
		LRR 14	326..348		7/21 (33%)
		leucine-rich repeat	328..350	CDD:275380	7/21 (33%)
		LRR 15	350..371		4/20 (20%)
		leucine-rich repeat	351..370	CDD:275380	4/18 (22%)
		leucine-rich repeat	374..399	CDD:275380	5/24 (21%)
		LRR 16	374..397		4/22 (18%)
		LRR 17	398..422		5/24 (21%)
		LRR_8	399..456	CDD:290566	16/58 (28%)
		leucine-rich repeat	400..422	CDD:275380	5/22 (23%)
		leucine-rich repeat	423..445	CDD:275380	5/22 (23%)
		LRR 18	424..443		4/19 (21%)
		LRR 19	444..466		9/22 (41%)
		leucine-rich repeat	446..468	CDD:275380	9/22 (41%)
		LRR 20	468..489		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910