DRSC/TRiP Functional Genomics Resources

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Protein Alignment rk and LRRC9

DIOPT Version :9

Sequence 1:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster
Sequence 2:NP_001342201.1 Gene:LRRC9 / 341883 HGNCID:19848 Length:1494 Species:Homo sapiens


Alignment Length:649 Identity:153/649 - (23%)
Similarity:247/649 - (38%) Gaps:188/649 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 LQHLQQQQQQNPQTVQQLSQITVNRTSKSASVTPTGIRENVMLPSADPEKEAQILYE-----KSL 116
            |:||.....|..::..:::.:..:.|    |:....|:.|..      :|.|.:...     |:|
Human   762 LKHLDLSWNQLKKSGNEINMLCKHTT----SLLTLDIQHNPW------QKPATLRLSVIGRLKTL 816

  Fly   117 QEYHGSQLS--TASTATDVIAGKRTL------HS--------ICERW-----------LQKHCHC 154
            ...:|..:|  .|:.|...|||.|..      ||        |...|           |..|.|.
Human   817 THLNGVFISEEEATAAMKFIAGTRITQLSLLRHSSTKEERPRILSIWPSAKILTQVSKLGPHLHL 881

  Fly   155 TGS--LEVLRLSCRGIGILAVPVNLP--NEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSI 215
            :|:  |::..|:..|..:..: .||.  ..:......||||||:|.....:  |||||||..|.|
Human   882 SGNCYLKITALNLDGQHLFEI-TNLEKLENLKWASFSNNNLTKMEGLESCI--NLEELTLDGNCI 943

  Fly   216 INMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQK---L 277
            ..::  ....:.||.|||:.|..|......:|..:..|.||.|..|.:.||.|     |||   |
Human   944 SKIE--GISKMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSG-----LQKSFTL 1001

  Fly   278 RTLRLEGNLFYRIPTNA----LAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKI 338
            ..|.:..|.   |..|.    |.||..|..|::..|:: |.|.|::    .|.|:.         
Human  1002 VELYISNNY---IAVNQEMHNLKGLCNLVILDMCGNII-IWNQENY----RLFVIF--------- 1049

  Fly   339 SAGALKNLTALKVLE-------------------LDDNLISSLPEGLSKLSQLQELSITSNRLRW 384
                  :|..||.|:                   |..::|:. .:|.|...|:|||:.||:.:|.
Human  1050 ------HLPELKALDGIPIEPSETDSAKDLFGGRLTSDMIAE-RQGHSNFKQMQELNWTSSSIRT 1107

  Fly   385 INDTELPR------------------------SMQMLDMRANPLSTISPG--------------- 410
            ::...:.:                        ::::|.:..|.:.:|.|.               
Human  1108 VDLIPVDQFRNVCNVNLQNNHLTSFSGLIYLPNVKVLCLNYNHIESIMPRLKPQTHLTSRQLLYQ 1172

  Fly   411 -------AFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSL 468
                   ..:|:||..:    |:.:..:.|.:  .|:||:|.|...||    .||         :
Human  1173 KVPSSGYGQQGISKTNR----DIMSSENLPPI--MHSLEVLHLGYNGI----CNL---------I 1218

  Fly   469 ELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIP 533
            :|:.|.|         |:|:.|.|..|:|.:::|  .:.|..|.:|::.:|||::....||....
Human  1219 QLQLNRL---------RNLKFLFLQGNEISQVEG--LDNLVVLQELVVDHNRIRSFNDSAFAKPS 1272

  Fly   534 KLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPE----SGLRALLHLKTFNNPKLRE 593
            .|..|.||.|.:..:.|  ......||.|.||.|...::.|    ..:..|..|..:.||..|:
Human  1273 SLLALHLEENRLRELGK--LQSLVKLEKLFLGYNKIQDITELEKLDVISTLRELTVYGNPICRK 1334

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rkNP_476702.1 leucine-rich repeat 158..179 CDD:275380 5/22 (23%)
LRR_RI 180..>383 CDD:238064 65/228 (29%)
leucine-rich repeat 183..204 CDD:275380 7/20 (35%)
LRR_8 203..263 CDD:290566 22/59 (37%)
leucine-rich repeat 205..228 CDD:275380 8/22 (36%)
leucine-rich repeat 229..252 CDD:275380 7/22 (32%)
LRR_8 252..311 CDD:290566 22/65 (34%)
leucine-rich repeat 253..276 CDD:275380 9/22 (41%)
leucine-rich repeat 277..300 CDD:275380 8/26 (31%)
LRR_8 299..359 CDD:290566 13/78 (17%)
leucine-rich repeat 301..324 CDD:275380 6/22 (27%)
leucine-rich repeat 325..348 CDD:275380 3/22 (14%)
LRR_RI 327..567 CDD:238064 63/304 (21%)
leucine-rich repeat 349..371 CDD:275380 7/40 (18%)
LRR_8 370..425 CDD:290566 14/100 (14%)
leucine-rich repeat 372..393 CDD:275380 6/44 (14%)
leucine-rich repeat 394..415 CDD:275380 4/42 (10%)
leucine-rich repeat 418..486 CDD:275380 14/67 (21%)
leucine-rich repeat 441..464 CDD:275378 8/22 (36%)
LRR_8 487..545 CDD:290566 19/57 (33%)
leucine-rich repeat 487..510 CDD:275380 7/22 (32%)
leucine-rich repeat 511..534 CDD:275380 7/22 (32%)
LRR_8 533..589 CDD:290566 15/59 (25%)
leucine-rich repeat 535..558 CDD:275380 6/22 (27%)
leucine-rich repeat 559..580 CDD:275380 7/24 (29%)
7tm_4 764..>892 CDD:304433
7tm_1 770..1017 CDD:278431
LRRC9NP_001342201.1 leucine-rich repeat 37..51 CDD:275380
leucine-rich repeat 56..77 CDD:275380
leucine-rich repeat 78..99 CDD:275380
LRR_9 97..246 CDD:317038
leucine-rich repeat 100..121 CDD:275380
leucine-rich repeat 122..143 CDD:275380
leucine-rich repeat 144..166 CDD:275380
leucine-rich repeat 192..223 CDD:275381
leucine-rich repeat 698..717 CDD:275380
LRR_8 716..772 CDD:316378 3/9 (33%)
leucine-rich repeat 718..739 CDD:275380
leucine-rich repeat 740..761 CDD:275380
leucine-rich repeat 762..788 CDD:275380 5/29 (17%)
leucine-rich repeat 789..846 CDD:275380 14/62 (23%)
leucine-rich repeat 847..910 CDD:275380 13/63 (21%)
leucine-rich repeat 911..932 CDD:275380 7/22 (32%)
leucine-rich repeat 933..954 CDD:275380 8/22 (36%)
LRR_9 935..1085 CDD:317038 47/179 (26%)
leucine-rich repeat 955..978 CDD:275380 7/22 (32%)
leucine-rich repeat 1026..1094 CDD:275380 16/88 (18%)
leucine-rich repeat 1141..1166 CDD:275380 4/24 (17%)
leucine-rich repeat 1167..1203 CDD:275380 5/41 (12%)
LRR_8 1203..1260 CDD:316378 22/80 (28%)
leucine-rich repeat 1204..1227 CDD:275380 11/44 (25%)
leucine-rich repeat 1228..1249 CDD:275380 7/22 (32%)
LRR_9 <1236..1365 CDD:317038 29/103 (28%)
leucine-rich repeat 1250..1273 CDD:275380 7/22 (32%)
leucine-rich repeat 1274..1295 CDD:275380 6/22 (27%)
leucine-rich repeat 1296..1320 CDD:275380 7/23 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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