DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Tlr9

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_937764.1	Gene:	Tlr9 / 338457	RGDID:	631352	Length:	1032	Species:	Rattus norvegicus

Alignment Length:	958	Identity:	225/958 - (23%)
Similarity:	349/958 - (36%)	Gaps:	290/958 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 LYEKSLQEYHGSQLSTASTATDVIAGK-RTLH--------SICERWLQKHCHCTGSLEVLRLSCR 166
            |:.||:..:..::..:..|:..:||.: ..||        ::.:..|:.:|...| |..|..|||
  Rat    48 LFLKSVPHFSAAEPRSNITSLSLIANRIHHLHNLDFVHLPNVRQLNLKWNCPPPG-LSPLHFSCR 111

  Fly   167 GI--------------------GILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLS 211
            ..                    ||..|| .||:.:..|.|.:.|:..|:|:|.....:|..|.:.
  Rat   112 MTIEPKTFLAMRMLEELNLSYNGITTVP-RLPSSLTNLSLSHTNILVLDASSLAGLHSLRVLFMD 175

  Fly   212 D--------NSIINMDPNAFYGLAKLKRLSLQNCGL----KSLPPQSFQGLAQLTSLQLNGNALV 264
            .        |..:|:.|:||.||:.|..|||:...|    :.|||       .|..|.|:.|.:|
  Rat   176 GNCYYKNPCNGAVNVTPDAFLGLSNLTHLSLKYNNLTEVPRQLPP-------SLEYLLLSYNLIV 233

  Fly   265 SLDGDCLGHLQKLRTLRLEGN------------------------LFYRIPTNALAGLRTLEALN 305
            .|..:.|.:|..||.|.:.||                        .|:.        |..||.|.
  Rat   234 KLGPEDLANLTSLRVLDVGGNCRRCDHAPDLCTECRQKSLDLHPQTFHH--------LSHLEGLV 290

  Fly   306 LGSNLLTIINDEDFPRMPNLIVLLLKRN----QIMKISAGALKNLTALKVLELDDNLISS----- 361
            |..:.|..:|.:.|..:.||.||.|..|    .|.|.|  |.:|||.|:.|:|..|....
  Rat   291 LKDSSLHSLNSKWFQGLVNLSVLDLSENFLYESINKTS--AFQNLTRLRKLDLSFNYCKKVSFAR 353

  Fly   362 --LPEGLSKLSQLQELS--------ITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMS 416
              |......|..||||:        :..|.|||:  ..||: :..|.::.|.::......|....
  Rat   354 LHLASSFKSLVSLQELNMNGIFFRLLNKNTLRWL--AGLPK-LHTLHLQMNFINQAQLSVFSTFR 415

  Fly   417 KLRKLILSDVR-----TL-RSFPELEACHALEILKLDRA--GIQEVPANLCRQTPRLKSLELKTN 473
            .||.:.||:.|     || |..||          |.|.|  |: ..||:|   ||.|.|..:..|
  Rat   416 ALRFVDLSNNRISGPPTLSRVAPE----------KADEAEKGV-PWPASL---TPALPSTPVSKN 466

  Fly   474 SLKRIPNLSSCRDLRL-LDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRI-KALPQDAFQGIPKLQ 536
            .:.|      |::||. :|||.|.:..|:.:.|..|..|..|.||:|.| :|:....|..:..|:
  Rat   467 FMVR------CKNLRFTMDLSRNNLVTIKPEMFVNLSHLQCLSLSHNCIAQAVNGSQFLPLTNLK 525

  Fly   537 LLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFP 601
            :|||..|::...|.::||....|:.|:|..|..|    ..::.:.|          .|.......
  Rat   526 VLDLSYNKLDLYHSKSFSELPQLQALDLSYNSQP----FSMQGIGH----------NFSFLANLS 576

  Fly   602 RIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAV---LFPSDAEFDMTLWNNSMMNIWPQMHNL 663
            |:|.|.|::                   :.:...|   |:.:..|: :....|.:..:|.:
  Rat   577 RLQNLSLAH-------------------NDIHSRVSSRLYSTSVEY-LDFSGNGVGRMWDE---- 617

  Fly   664 SKQLGASMHDPWETAINFNEEQ-----LQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFS 723
             :.|.........:.|:.:..|     |:.|....:..|..:..|.::.:|            |.
  Rat   618 -EDLYLYFFQDLRSLIHLDLSQNKLHILRPQNLNYLPKSLTKLSFRDNHLS------------FF 669

  Fly   724 GMSTEDFQPGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVP 788
            ..|:..|.| :::.|.:.|.                     ||..|.|||:....|.  .|:||.
  Rat   670 NWSSLAFLP-NLRDLDLAGN---------------------LLKALTNGTLPNGTLL--QKLDVS 710

  Fly   789 RFLVCNLAAADFFMGIYL-------GILAIVDAATLGEFRMFAIPWQMS---------------- 830
            ...:..:..|.|.:.:.|       .||..||.:..|...|......:|
  Rat   711 SNSIVFVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMNLTVLDVSSNPLHCACGAPFVDLL 775

  Fly   831 -------------VLC----QLSG---FLA--------VLSSE---LSVYTLAVITLERNYAITH 864
                         |.|    ||.|   |..        |||.:   ||:..:||.|:
  Rat   776 LEVQTKVPGLANGVKCGSPRQLQGRSIFAQDLRLCLDDVLSRDCFGLSLLAVAVGTV-------- 832

  Fly   865 AIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFE 912
                   |.|.|......|.:.|.|.:|.:||  ::..|:.|..||::
  Rat   833 -------LPLLQHLCGWDVWYCFHLCLAWLPL--LTRGRRSAQALPYD 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	10/40 (25%)
		LRR_RI	180..>383	CDD:238064	69/257 (27%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	21/71 (30%)
		leucine-rich repeat	205..228	CDD:275380	9/30 (30%)
		leucine-rich repeat	229..252	CDD:275380	8/26 (31%)
		LRR_8	252..311	CDD:290566	19/82 (23%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	7/46 (15%)
		LRR_8	299..359	CDD:290566	24/63 (38%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	11/26 (42%)
		LRR_RI	327..567	CDD:238064	82/268 (31%)
		leucine-rich repeat	349..371	CDD:275380	6/28 (21%)
		LRR_8	370..425	CDD:290566	16/62 (26%)
		leucine-rich repeat	372..393	CDD:275380	10/28 (36%)
		leucine-rich repeat	394..415	CDD:275380	3/20 (15%)
		leucine-rich repeat	418..486	CDD:275380	24/75 (32%)
		leucine-rich repeat	441..464	CDD:275378	8/24 (33%)
		LRR_8	487..545	CDD:290566	22/59 (37%)
		leucine-rich repeat	487..510	CDD:275380	9/23 (39%)
		leucine-rich repeat	511..534	CDD:275380	8/23 (35%)
		LRR_8	533..589	CDD:290566	14/55 (25%)
		leucine-rich repeat	535..558	CDD:275380	8/22 (36%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433	40/181 (22%)
		7tm_1	770..1017	CDD:278431	44/197 (22%)
Tlr9	NP_937764.1	leucine-rich repeat	43..64	CDD:275380	3/15 (20%)
		LRR_8	63..135	CDD:290566	13/72 (18%)
		leucine-rich repeat	65..88	CDD:275380	5/22 (23%)
		leucine-rich repeat	89..124	CDD:275380	8/35 (23%)
		LRR_RI	123..373	CDD:238064	74/267 (28%)
		leucine-rich repeat	125..144	CDD:275380	6/19 (32%)
		LRR_8	143..211	CDD:290566	19/67 (28%)
		leucine-rich repeat	145..168	CDD:275380	6/22 (27%)
		leucine-rich repeat	169..200	CDD:275380	9/30 (30%)
		LRR_8	199..254	CDD:290566	19/61 (31%)
		leucine-rich repeat	201..221	CDD:275380	8/26 (31%)
		leucine-rich repeat	222..245	CDD:275380	8/22 (36%)
		leucine-rich repeat	246..285	CDD:275380	7/46 (15%)
		LRR_8	284..344	CDD:290566	23/61 (38%)
		leucine-rich repeat	286..309	CDD:275380	7/22 (32%)
		LRR_RI	310..556	CDD:238064	83/270 (31%)
		leucine-rich repeat	310..335	CDD:275380	11/26 (42%)
		leucine-rich repeat	336..365	CDD:275380	6/28 (21%)
		leucine-rich repeat	393..416	CDD:275380	3/22 (14%)
		leucine-rich repeat	477..498	CDD:275380	7/20 (35%)
		LRR_RI	<490..692	CDD:238064	50/274 (18%)
		LRR_8	497..556	CDD:290566	19/58 (33%)
		leucine-rich repeat	499..523	CDD:275380	8/23 (35%)
		leucine-rich repeat	524..547	CDD:275380	8/22 (36%)
		leucine-rich repeat	548..577	CDD:275380	7/42 (17%)
		leucine-rich repeat	578..630	CDD:275380	9/76 (12%)
		leucine-rich repeat	601..618	CDD:275380	3/22 (14%)
		LRR_8	629..690	CDD:290566	13/94 (14%)
		leucine-rich repeat	631..655	CDD:275380	4/23 (17%)
		leucine-rich repeat	656..679	CDD:275380	6/35 (17%)
		leucine-rich repeat	680..703	CDD:275380	8/43 (19%)
		LRR_8	704..763	CDD:290566	13/60 (22%)
		leucine-rich repeat	704..727	CDD:275380	5/24 (21%)
		leucine-rich repeat	728..746	CDD:275380	5/17 (29%)
		leucine-rich repeat	753..774	CDD:275380	1/20 (5%)
		TIR_2	870..1013	CDD:304906	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910