DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and lrrc40

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_956156.2	Gene:	lrrc40 / 334130	ZFINID:	ZDB-GENE-030131-6062	Length:	601	Species:	Danio rerio

Alignment Length:	529	Identity:	140/529 - (26%)
Similarity:	221/529 - (41%)	Gaps:	105/529 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 ERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELT 209
            :||.::     ..|..|.||...:..:...|.|...:||||:.:|.|:.| .:|......|::|.
Zfish    74 DRWWEQ-----TDLTKLLLSSNKLQSIPDDVKLLPALVVLDIHDNQLSSL-PDSIGDLEQLQKLI 132

  Fly   210 LSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLP----------------------PQSFQGLAQ 252
            ||.|.:..: |:..:.|..|:.|.||...::.:|                      |:|...|..
Zfish   133 LSHNKLTEL-PSGVWRLTNLRCLHLQQNLIEQIPRDLGQLVNLDDLDLSNNHLIDIPESLANLQN 196

  Fly   253 LTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDE 317
            |..|.|:.|.|.||. ..:..::.||.|....|....||. .||.:.:||.|.|..|.|..:
Zfish   197 LVKLDLSCNKLKSLP-PAISQMKNLRMLDCSRNQMESIPP-VLAQMESLEQLYLRHNKLRYL--- 256

  Fly   318 DFPRMP---NLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITS 379
              |.:|   .|..|....|||..:.|..||:|.||.:|||.||.:.||||.::.|..|:.|.:|:
Zfish   257 --PELPCCKTLKELHCGNNQIEVLEAEHLKHLNALSLLELRDNKVKSLPEEITLLQGLERLDLTN 319

  Fly   380 NRLRWINDTELP------RSMQMLDMRANPLSTISPGAF-RGMSKLRKLILSDVR---------- 427
            |.:     :.||      ..::.|.:..|||..|..... :|..:|.|.:.|.|:
Zfish   320 NDI-----SSLPCGLGTLPKLKSLSLEGNPLRAIRRDLLTKGTGELLKYLRSRVQEPPNGGLKEE 379

  Fly   428 -----TLRSFPELEACHALEILK-LDRAGIQE----------------------------VPANL 458
                 |.:|..::. .||::.|| ||.:..|:                            ||..:
Zfish   380 PKTAMTFQSQAKIN-IHAIKTLKTLDYSEKQDASIPDDVLDAVDGNPVANVNFSKNQLTAVPHRI 443

  Fly   459 CRQTPRLKSLELKTNSLKRIP-NLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIK 522
            ......|..:.|..|.|..|| :....:.|..:||.:|.:..:. ....||.:|..::||:||.|
Zfish   444 VDLKDTLADINLGFNKLTTIPADFCHLKQLMHIDLRNNLLISLP-MELEGLIKLRSVILSFNRFK 507

  Fly   523 ALPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPE-----SGLRAL-L 581
            :.|:..:: ||.|:.:.:..|::..|........:.|..|:|.||...::|.     :.|||| |
Zfish   508 SFPEVLYR-IPSLETILISSNQVGGIDAVQMKTLSRLSTLDLSNNDIMQVPPELGNCTSLRALML 571

  Fly   582 HLKTFNNPK 590
            ....|.||:
Zfish   572 DGNPFRNPR 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	71/227 (31%)
		leucine-rich repeat	183..204	CDD:275380	7/20 (35%)
		LRR_8	203..263	CDD:290566	19/81 (23%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	8/44 (18%)
		LRR_8	252..311	CDD:290566	20/58 (34%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	24/62 (39%)
		leucine-rich repeat	301..324	CDD:275380	8/25 (32%)
		leucine-rich repeat	325..348	CDD:275380	9/22 (41%)
		LRR_RI	327..567	CDD:238064	74/291 (25%)
		leucine-rich repeat	349..371	CDD:275380	11/21 (52%)
		LRR_8	370..425	CDD:290566	14/61 (23%)
		leucine-rich repeat	372..393	CDD:275380	6/26 (23%)
		leucine-rich repeat	394..415	CDD:275380	5/21 (24%)
		leucine-rich repeat	418..486	CDD:275380	21/112 (19%)
		leucine-rich repeat	441..464	CDD:275378	7/51 (14%)
		LRR_8	487..545	CDD:290566	17/57 (30%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	16/61 (26%)
		leucine-rich repeat	535..558	CDD:275380	3/22 (14%)
		leucine-rich repeat	559..580	CDD:275380	8/25 (32%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrrc40	NP_956156.2	LRR 1	33..56
		LRR 2	79..101		5/26 (19%)
		LRR_8	82..138	CDD:290566	19/56 (34%)
		leucine-rich repeat	82..104	CDD:275380	6/21 (29%)
		LRR_RI	99..343	CDD:238064	76/257 (30%)
		LRR 3	102..124		8/22 (36%)
		leucine-rich repeat	105..127	CDD:275380	8/22 (36%)
		LRR 4	125..148		6/23 (26%)
		LRR_8	127..184	CDD:290566	12/57 (21%)
		leucine-rich repeat	128..150	CDD:275380	7/22 (32%)
		LRR 5	150..170		5/19 (26%)
		leucine-rich repeat	151..173	CDD:275380	5/21 (24%)
		LRR 6	171..193		2/21 (10%)
		leucine-rich repeat	174..196	CDD:275380	3/21 (14%)
		LRR 7	194..217		8/23 (35%)
		LRR_8	196..253	CDD:290566	20/58 (34%)
		leucine-rich repeat	197..219	CDD:275380	7/22 (32%)
		LRR 8	219..239		7/20 (35%)
		leucine-rich repeat	220..242	CDD:275380	8/22 (36%)
		LRR 9	240..264		8/28 (29%)
		leucine-rich repeat	243..288	CDD:275380	17/49 (35%)
		LRR_8	263..322	CDD:290566	25/58 (43%)
		LRR 10	266..285		6/18 (33%)
		LRR 11	286..308		12/21 (57%)
		leucine-rich repeat	289..311	CDD:275380	11/21 (52%)
		LRR 12	309..334		7/29 (24%)
		leucine-rich repeat	335..354	CDD:275380	5/18 (28%)
		LRR 13	336..355		5/18 (28%)
		LRR 14	397..420		5/22 (23%)
		leucine-rich repeat	400..449	CDD:275380	7/48 (15%)
		LRR 15	423..446		2/22 (9%)
		LRR 16	447..469		6/21 (29%)
		LRR_8	449..506	CDD:290566	16/57 (28%)
		leucine-rich repeat	450..472	CDD:275380	6/21 (29%)
		LRR 17	470..492		4/22 (18%)
		leucine-rich repeat	473..495	CDD:275380	6/22 (27%)
		LRR 18	493..516		8/23 (35%)
		leucine-rich repeat	496..518	CDD:275380	8/22 (36%)
		LRR_8	517..576	CDD:290566	15/58 (26%)
		LRR 19	518..539		3/20 (15%)
		leucine-rich repeat	519..542	CDD:275380	3/22 (14%)
		LRR 20	540..563		6/22 (27%)
		leucine-rich repeat	543..565	CDD:275380	6/21 (29%)
		LRR 21	565..586		8/16 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910