DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lgr6

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001028581.1	Gene:	Lgr6 / 329252	MGIID:	2441805	Length:	967	Species:	Mus musculus

Alignment Length:	963	Identity:	299/963 - (31%)
Similarity:	447/963 - (46%)	Gaps:	150/963 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |||.....:|...|..:|:..||.:|......|||..||||:|:...|.....||||.||.|.:.
Mouse    39 CHCQEDGIMLSADCSELGLSVVPADLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS 103

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSL------DGDCLGHLQ 275
            ::...||.||..||.|.||:..|:.:|.::...|..|.||:|:.| |:||      :|     |.
Mouse   104 HIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDAN-LISLVPERSFEG-----LS 162

  Fly   276 KLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISA 340
            .||.|.|:.|....||..||..|..|:|:.|..|.:..|.|..|..:.:|:||.|..|:|..:..
Mouse   163 SLRHLWLDDNALTEIPVRALNNLPALQAMTLALNHIRHIPDYAFQNLTSLVVLHLHNNRIQHVGT 227

  Fly   341 GALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRS--MQMLDMRANP 403
            .:.:.|..|:.|:|:.|.:...|..:..|.:||||...:|.::.|.:.....|  :|.:....||
Mouse   228 HSFEGLHNLETLDLNYNELQEFPLAIRTLGRLQELGFHNNNIKAIPEKAFMGSPLLQTIHFYDNP 292

  Fly   404 LSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSL 468
            :..:...||:.:|||..|.|:....::.||:|:...:||||.|.||||:.:|..:|:|.|||:.|
Mouse   293 IQFVGRSAFQYLSKLHTLSLNGATDIQEFPDLKGTTSLEILTLTRAGIRLLPPGVCQQLPRLRIL 357

  Fly   469 ELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIP 533
            ||..|.::.:|:|..|                        ::|.::.|.:||||.:..|.|..:.
Mouse   358 ELSHNQIEELPSLHRC------------------------QKLEEIGLRHNRIKEIGADTFSQLG 398

  Fly   534 KLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPD 598
            .||.|||..|.|..||.||||...:|..|:|.:|....||.:||..|:|||...|..|.:....|
Mouse   399 SLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKD 463

  Fly   599 TFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNL 663
            :||:::.|.:.|||.|||:  .:..|..|.:.|.|.....|.:.|..
Mouse   464 SFPKLRILEVPYAYQCCAY--GICASFFKTSGQWQAEDFHPEEEEAP------------------ 508

  Fly   664 SKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTE 728
            .:.||. :....|...:.:.::||                                     |.||
Mouse   509 KRPLGL-LAGQAENHYDLDLDELQ-------------------------------------MGTE 535

  Fly   729 DFQP-GSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCS-RSKMDVPRFL 791
            |.:| .||||.|:||||.||..||:.|.:|..||.:.|||:|.||.|:..:..| .|.:...:.:
Mouse   536 DSKPHPSVQCSPVPGPFKPCEHLFESWGIRLAVWAIVLLSVLCNGLVLLTVFASGPSPLSPVKLV 600

  Fly   792 VCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITL 856
            |..:|.|:...||..|:||.|||.|.|:|..:...|:..:.||.:||||||.||.||..|.:..:
Mouse   601 VGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLGCQATGFLAVLGSEASVLLLTLAAV 665

  Fly   857 ERNYAITHAIHLNKRLSLKQAGYIMSVGWV---------FALIMALMPLVGVSDYRKFAVCLPFE 912
            :.:.::|         .::..|...|.|.|         .|.:.|.:||..|.:|....:|||:.
Mouse   666 QCSISVT---------CVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYA 721

  Fly   913 TTTG-PASLTYVISLMFINGCAFLTLMGCYLKMYWAI-RG--SQAWNTNDSRIAKRMALLVFTDF 973
            ...| ||:|.:.::|:.:|...||.:.|.|:|:|..: ||  ...|   |..:.:.:|.|:|.|.
Mouse   722 PPEGRPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVW---DCAMVRHVAWLIFADG 783

  Fly   974 LCWSPIAFFSITAIFGLQLISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKDCVTLCKHFEES 1038
            |.:.|:||.|..::.||..::.|..|...:.||||.:|.||.||.:....|:.|...|..
Mouse   784 LLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLWP----- 843

  Fly  1039 RVVGGGGPGGRGAVARTKRGDLPPP----------------LLPAAAVAHPPG 1075
                  .|...|.:|....|:|...                :|.|:....|||
Mouse   844 ------SPRSPGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGQPPG 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	73/208 (35%)
		leucine-rich repeat	183..204	CDD:275380	9/20 (45%)
		LRR_8	203..263	CDD:290566	24/59 (41%)
		leucine-rich repeat	205..228	CDD:275380	11/22 (50%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	24/64 (38%)
		leucine-rich repeat	253..276	CDD:275380	10/28 (36%)
		leucine-rich repeat	277..300	CDD:275380	10/22 (45%)
		LRR_8	299..359	CDD:290566	18/59 (31%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	78/241 (32%)
		leucine-rich repeat	349..371	CDD:275380	6/21 (29%)
		LRR_8	370..425	CDD:290566	17/56 (30%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	28/67 (42%)
		leucine-rich repeat	441..464	CDD:275378	12/22 (55%)
		LRR_8	487..545	CDD:290566	14/57 (25%)
		leucine-rich repeat	487..510	CDD:275380	0/22 (0%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	25/55 (45%)
		leucine-rich repeat	535..558	CDD:275380	13/22 (59%)
		leucine-rich repeat	559..580	CDD:275380	8/20 (40%)
		7tm_4	764..>892	CDD:304433	43/137 (31%)
		7tm_1	770..1017	CDD:278431	83/260 (32%)
Lgr6	NP_001028581.1	LRRNT	34..68	CDD:214470	9/28 (32%)
		LRR_4	70..107	CDD:289563	16/36 (44%)
		leucine-rich repeat	70..91	CDD:275380	9/20 (45%)
		LRR 1	91..112		9/20 (45%)
		LRR_8	92..150	CDD:290566	24/58 (41%)
		LRR_4	92..131	CDD:289563	17/38 (45%)
		leucine-rich repeat	92..115	CDD:275380	11/22 (50%)
		LRR 2	115..136		7/20 (35%)
		leucine-rich repeat	116..139	CDD:275380	8/22 (36%)
		LRR_8	138..198	CDD:290566	24/65 (37%)
		LRR 3	139..160		8/21 (38%)
		leucine-rich repeat	140..163	CDD:275380	10/28 (36%)
		LRR_RI	143..392	CDD:238064	86/278 (31%)
		LRR 4	163..186		9/22 (41%)
		leucine-rich repeat	164..187	CDD:275380	10/22 (45%)
		LRR_8	186..246	CDD:290566	18/59 (31%)
		LRR 5	187..208		7/20 (35%)
		leucine-rich repeat	188..211	CDD:275380	7/22 (32%)
		LRR 6	211..232		6/20 (30%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		LRR 7	235..256		5/20 (25%)
		leucine-rich repeat	236..258	CDD:275380	6/21 (29%)
		LRR_8	258..314	CDD:290566	17/55 (31%)
		LRR 8	258..279		6/20 (30%)
		leucine-rich repeat	259..282	CDD:275380	7/22 (32%)
		LRR 9	282..302		4/19 (21%)
		leucine-rich repeat	283..304	CDD:275380	5/20 (25%)
		LRR 10	303..325		7/21 (33%)
		LRR_8	305..364	CDD:290566	27/58 (47%)
		leucine-rich repeat	307..348	CDD:275380	16/40 (40%)
		LRR 11	329..350		11/20 (55%)
		LRR 12	353..374		9/44 (20%)
		leucine-rich repeat	354..375	CDD:275380	8/44 (18%)
		LRR_8	375..434	CDD:290566	25/58 (43%)
		LRR 13	375..396		8/20 (40%)
		leucine-rich repeat	376..399	CDD:275380	8/22 (36%)
		LRR 14	399..420		12/20 (60%)
		leucine-rich repeat	400..421	CDD:275380	13/20 (65%)
		LRR 15	423..443		7/19 (37%)
		leucine-rich repeat	424..444	CDD:275380	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10866
eggNOG	1	0.900	-	-		E1_KOG2087
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2026
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43490
orthoMCL	1	0.900	-	-		OOG6_106088
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2481
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.720