DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and AgaP_AGAP003878

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_559671.4	Gene:	AgaP_AGAP003878 / 3290920	VectorBaseID:	AGAP003878	Length:	569	Species:	Anopheles gambiae

Alignment Length:	481	Identity:	109/481 - (22%)
Similarity:	195/481 - (40%)	Gaps:	95/481 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 ILAVPVNLP-NEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLS 233
            ||.|....| ..:..:::...:|:::|..:|...|.|.::.:..|.:..::...|.||..|..|.
Mosquito    71 ILTVDSFAPFTNLTSIEIFQGSLSRIEPGAFEKTPALFKIIIRSNVLSALEDYTFRGLDALHILY 135

  Fly   234 LQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGL 298
            |.:..|.|:.|.:|.||..||.|.|:||.:..|..........||::.|..|:...:|......:
Mosquito   136 LISNNLTSIAPNAFYGLKNLTQLVLSGNQIAQLPPTLFSSTPMLRSVSLSNNMLTELPAGIFDSI 200

  Fly   299 RTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKVLELDDNLISSLP 363
            ..|..|:|..|.|...   |||.: .:.:|.|..|.:..:..|     ..:||::.:.|.|
Mosquito   201 DYLFKLDLSYNQLKTF---DFPDL-KVTLLFLHNNSLTSLHVG-----DHVKVVQANHNRI---- 252

  Fly   364 EGLSKLS----QLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMSKLRKLILS 424
               :|||    .:.:|.::.|.:..:....|.:::..|.:..|||...|  .|..:.:|.:|.||
Mosquito   253 ---AKLSGSGFNITDLLLSDNAITDVTPIMLMKNISKLSLSNNPLQPDS--VFGSLEQLEELFLS 312

  Fly   425 DVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTNSLKRIPNLSSCRDLRL 489
            ....:                     |.|       ||               ..|||.   :.|
Mosquito   313 HTSIM---------------------INE-------QT---------------FANLSW---MSL 331

  Fly   490 LDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALP-QDAFQGIPKLQLLDLEGNEISYIHKEAF 553
            ||||.|.:.::..:.|:.:.:|..|:::||||:.:. .:..:.:|:|::|::.||..:..:.|..
Mosquito   332 LDLSYNNMTELDFRMFSSMNKLKSLIVAYNRIETINFIELREYLPELRVLEICGNGWNATYMERM 396

  Fly   554 ----------SGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLIL 608
                      :....|.:..:.:::|.||..:|:...  .|..|:  ..::...|....|:..|.
Mosquito   397 LSKMRKHKLRADMQGLSNSLIFSSVFVELCSAGVETT--TKAAND--YSDYYAEDFGDGIEQEIA 457

  Fly   609 SYAYHCCAFLPLVAMSSQKKTSQVQE 634
            .|           |.||.:..|.|.|
Mosquito   458 EY-----------ASSSPRPWSTVSE 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	4/9 (44%)
		LRR_RI	180..>383	CDD:238064	51/206 (25%)
		leucine-rich repeat	183..204	CDD:275380	3/20 (15%)
		LRR_8	203..263	CDD:290566	21/59 (36%)
		leucine-rich repeat	205..228	CDD:275380	5/22 (23%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	16/58 (28%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		LRR_8	299..359	CDD:290566	15/59 (25%)
		leucine-rich repeat	301..324	CDD:275380	8/22 (36%)
		leucine-rich repeat	325..348	CDD:275380	4/22 (18%)
		LRR_RI	327..567	CDD:238064	51/254 (20%)
		leucine-rich repeat	349..371	CDD:275380	7/25 (28%)
		LRR_8	370..425	CDD:290566	13/58 (22%)
		leucine-rich repeat	372..393	CDD:275380	3/20 (15%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	11/67 (16%)
		leucine-rich repeat	441..464	CDD:275378	4/22 (18%)
		LRR_8	487..545	CDD:290566	18/58 (31%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		leucine-rich repeat	511..534	CDD:275380	6/23 (26%)
		LRR_8	533..589	CDD:290566	13/65 (20%)
		leucine-rich repeat	535..558	CDD:275380	5/32 (16%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
AgaP_AGAP003878	XP_559671.4	leucine-rich repeat	63..82	CDD:275380	4/10 (40%)
		leucine-rich repeat	83..106	CDD:275380	3/22 (14%)
		LRR_8	105..165	CDD:290566	21/59 (36%)
		LRR_4	131..170	CDD:289563	16/38 (42%)
		leucine-rich repeat	131..154	CDD:275380	9/22 (41%)
		LRR_RI	153..386	CDD:238064	67/296 (23%)
		leucine-rich repeat	155..178	CDD:275380	7/22 (32%)
		LRR_8	179..233	CDD:290566	16/57 (28%)
		leucine-rich repeat	179..202	CDD:275380	5/22 (23%)
		leucine-rich repeat	203..241	CDD:275380	12/46 (26%)
		leucine-rich repeat	242..261	CDD:275380	7/25 (28%)
		LRR_8	261..316	CDD:290566	13/56 (23%)
		leucine-rich repeat	262..283	CDD:275380	3/20 (15%)
		leucine-rich repeat	284..305	CDD:275380	6/22 (27%)
		LRR_8	305..363	CDD:290566	22/103 (21%)
		leucine-rich repeat	306..328	CDD:275380	10/64 (16%)
		leucine-rich repeat	329..350	CDD:275380	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910