DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and GPRALS2

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_003435928.1	Gene:	GPRALS2 / 3290518	VectorBaseID:	AGAP001773	Length:	359	Species:	Anopheles gambiae

Alignment Length:	302	Identity:	72/302 - (23%)
Similarity:	120/302 - (39%)	Gaps:	72/302 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   765 LLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIP--- 826
            :..||||..||.|:|.:.........|:.|||.||..                  |.:|.||
Mosquito    53 ITGLLGNALVVLVVLSNPQMRSTTNLLIINLAIADLL------------------FVVFCIPFTA 99

  Fly   827 -------WQMSVL-CQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSV 883
                   |....| |:...:|.|:::..|:|||.:::|:|..|:.|.|......:.:.....:::
Mosquito   100 TDYVLASWPFGELWCKSVQYLIVVTAHASIYTLVLMSLDRFLAVVHPIASMVIRTERNTVLAITI 164

  Fly   884 GWVFALIMALMPLV---GVSDY----RKFAVCLPFETTTGPA---------SLTYVISLMFINGC 932
            .||. :|...:|:.   |::.:    |:...| .|.....|:         ..:||:.|:.|:
Mosquito   165 LWVL-IITTGLPVSFAHGINKFKYHDREIETC-GFLEKDSPSWAAFHIAFFLSSYVVPLILIS-- 225

  Fly   933 AFLTLMGCYLKMYW--AIRGSQAWNTNDSRIAKRMALLVFTDFL-CWSPIAFFSITAIFGLQLIS 994
               .|....|...|  ::.|..|.:....:...|:.::|...|. .|.||...       |.|.|
Mosquito   226 ---VLYMWMLSRLWRSSVGGRSAESKKGKKRVTRLVVIVVAAFASLWFPIQVI-------LVLKS 280

  Fly   995 LEQAKIFTVFVLPL----------NSCCNPFLYAIMTKQFKK 1026
            ::..|..|.|.:.|          :||.||.|||.:::.|:|
Mosquito   281 VDVFKPDTHFKISLQIVSHVLAYTSSCINPLLYAFLSENFRK 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064
		leucine-rich repeat	183..204	CDD:275380
		LRR_8	203..263	CDD:290566
		leucine-rich repeat	205..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_8	252..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		LRR_8	299..359	CDD:290566
		leucine-rich repeat	301..324	CDD:275380
		leucine-rich repeat	325..348	CDD:275380
		LRR_RI	327..567	CDD:238064
		leucine-rich repeat	349..371	CDD:275380
		LRR_8	370..425	CDD:290566
		leucine-rich repeat	372..393	CDD:275380
		leucine-rich repeat	394..415	CDD:275380
		leucine-rich repeat	418..486	CDD:275380
		leucine-rich repeat	441..464	CDD:275378
		LRR_8	487..545	CDD:290566
		leucine-rich repeat	487..510	CDD:275380
		leucine-rich repeat	511..534	CDD:275380
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433	35/137 (26%)
		7tm_1	770..1017	CDD:278431	65/286 (23%)
GPRALS2	XP_003435928.1	7tm_4	50..>171	CDD:304433	34/136 (25%)
		7tm_1	58..313	CDD:278431	65/286 (23%)
		7tm_4	<130..330	CDD:304433	48/207 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910