DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and TOLL5A

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_560220.3	Gene:	TOLL5A / 3289806	VectorBaseID:	AGAP000999	Length:	1057	Species:	Anopheles gambiae

Alignment Length:	521	Identity:	142/521 - (27%)
Similarity:	220/521 - (42%)	Gaps:	96/521 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 NLPN--------EVVVLDLGNNNLTKLEANSFF---MAPNLEELTLSDNS----IINMDPNAFYG 225
            ||||        :...|.:||.:|..| .::|.   ...::..|...||:    .:.:||..|..
Mosquito    72 NLPNFKFEELAYQNCPLPVGNQSLVDL-LSAFLDRTQLSSIRRLFFVDNAKLSGQVTLDPQLFAD 135

  Fly   226 LAKLKRLSLQNCGLKSLP-PQSFQ-------------------------GLAQLTSLQLNGNALV 264
            |..|:.||::|.....|. |:.|:                         .|.|||:|:|..|.|.
Mosquito   136 LPALQVLSMKNSSRMPLDNPELFKYLQSLTWIDLREGDGGSRNSKVLLHTLTQLTTLELTENELT 200

  Fly   265 SLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLL 329
            :|..:.:..|..|.:|.|..|...||  ...|.|..|.:|:|..|.|..:.::.|.::|||..|.
Mosquito   201 TLPTELITDLPSLGSLTLYHNKLERI--EQFADLPNLTSLDLTYNELDTLQEDVFYKLPNLTHLF 263

  Fly   330 LKRNQIMKISAGALKNLTALKVLELDDNLISSLPEG---LSKLSQLQELSITSNRLRWINDTELP 391
            |..|::..:.:|.||..|.|.|...|:...|.|..|   .:.|:.|:::|:::.:|     |.||
Mosquito   264 LNSNKLTSLPSGLLKRNTKLIVFRADNQHGSGLVLGDELFAGLTMLEDVSVSNCKL-----TTLP 323

  Fly   392 R-------SMQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPE--LEACHALEILKLD 447
            .       .:..||:..|.|.::.....|..|.|::|.|.....:...|:  |::.:.|.||.|.
Mosquito   324 EGLFTAASKLTKLDVSDNKLQSLPENLLRHSSILKELYLQHNELINMLPDTLLQSTNKLRILNLG 388

  Fly   448 RAGIQEVPANLCRQTPRLKSLELKTNSLKRIPN---LSSCRDLRLLDLSSNQIE---------KI 500
            ...:..:...|......|:.|.|:.|.|..|..   :|..:.|::|:||.||:.         .:
Mosquito   389 HNKLTTLSKYLLDSKNSLEELHLEYNQLYMIDRDAFISQAQSLKMLNLSHNQVALHVNGTDVFYL 453

  Fly   501 QGK-------PFNGLKQLNDLLLSYNRIKALPQDAFQG-IPKLQLLDLEGNEISYIHKEAFSGFT 557
            .||       ||..|.||.||.||||.|..:..| |:| :..||.|||..|.|..|..:.||..:
Mosquito   454 DGKTYYISQTPFYILAQLTDLDLSYNAIIKIFGD-FKGFMGNLQSLDLSHNLIMNISDKDFSFLS 517

  Fly   558 -ALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFPRIQTLILSYAYHC-CAFLPL 620
             .:|.:||.:|            .:.:.|||:.|...|.........|.|:...:.:| |....|
Mosquito   518 PKIEKVNLESN------------RITMFTFNDSKKSTFSNRSINTPRQILLADNSLNCDCISSSL 570

  Fly   621 V 621
            |
Mosquito   571 V 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	2/2 (100%)
		LRR_RI	180..>383	CDD:238064	63/238 (26%)
		leucine-rich repeat	183..204	CDD:275380	6/23 (26%)
		LRR_8	203..263	CDD:290566	21/89 (24%)
		leucine-rich repeat	205..228	CDD:275380	7/26 (27%)
		leucine-rich repeat	229..252	CDD:275380	8/48 (17%)
		LRR_8	252..311	CDD:290566	21/58 (36%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	8/22 (36%)
		LRR_8	299..359	CDD:290566	19/59 (32%)
		leucine-rich repeat	301..324	CDD:275380	6/22 (27%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	79/272 (29%)
		leucine-rich repeat	349..371	CDD:275380	7/24 (29%)
		LRR_8	370..425	CDD:290566	15/61 (25%)
		leucine-rich repeat	372..393	CDD:275380	6/27 (22%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	17/72 (24%)
		leucine-rich repeat	441..464	CDD:275378	5/22 (23%)
		LRR_8	487..545	CDD:290566	29/74 (39%)
		leucine-rich repeat	487..510	CDD:275380	11/38 (29%)
		leucine-rich repeat	511..534	CDD:275380	11/23 (48%)
		LRR_8	533..589	CDD:290566	17/56 (30%)
		leucine-rich repeat	535..558	CDD:275380	10/23 (43%)
		leucine-rich repeat	559..580	CDD:275380	4/20 (20%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
TOLL5A	XP_560220.3	leucine-rich repeat	98..121	CDD:275380	5/23 (22%)
		leucine-rich repeat	139..163	CDD:275380	7/23 (30%)
		LRR_8	211..269	CDD:290566	20/59 (34%)
		LRR_4	211..250	CDD:289563	13/40 (33%)
		leucine-rich repeat	213..234	CDD:275380	8/22 (36%)
		LRR_4	233..274	CDD:289563	12/40 (30%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		leucine-rich repeat	259..282	CDD:275380	7/22 (32%)
		leucine-rich repeat	283..308	CDD:275380	7/24 (29%)
		LRR_RI	300..531	CDD:238064	67/248 (27%)
		LRR_8	309..367	CDD:290566	15/62 (24%)
		leucine-rich repeat	309..332	CDD:275380	6/27 (22%)
		leucine-rich repeat	333..356	CDD:275380	5/22 (23%)
		LRR_8	357..416	CDD:290566	14/58 (24%)
		leucine-rich repeat	357..381	CDD:275380	5/23 (22%)
		leucine-rich repeat	382..405	CDD:275380	5/22 (23%)
		leucine-rich repeat	406..424	CDD:275380	6/17 (35%)
		leucine-rich repeat	431..470	CDD:275380	11/38 (29%)
		LRR_8	470..530	CDD:290566	26/72 (36%)
		leucine-rich repeat	471..494	CDD:275380	11/23 (48%)
		leucine-rich repeat	495..516	CDD:275380	10/20 (50%)
		leucine-rich repeat	589..705	CDD:275380
		leucine-rich repeat	706..731	CDD:275380
		TIR	843..981	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910