DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and lrrc8aa

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001025120.1	Gene:	lrrc8aa / 327642	ZFINID:	ZDB-GENE-030131-5853	Length:	795	Species:	Danio rerio

Alignment Length:	537	Identity:	129/537 - (24%)
Similarity:	196/537 - (36%)	Gaps:	155/537 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 MLPSADPEKEAQILYEKS----LQEYHGSQLSTAST----ATDVIAGKRTLHSICERWLQKHCHC 154
            |:...||      ||.|.    |.|..|::|...:.    |.:.:..:.|.:|  :..|:.|...
Zfish   363 MIDQYDP------LYSKRFAVFLSEVSGNKLRQLNLNNEWALEKLRQRITKNS--QEKLELHLFM 419

  Fly   155 TG----------SLEVLRLSCRGIGILAVPVNLPNEVVVLDLGN-------NNLTKLEANSF-FM 201
            ..          .||||:|.      |...:.:|  .::..|.|       :...::||.:. |:
Zfish   420 LSGIPDTVFDLVELEVLKLE------LIPDITIP--PIIAQLSNLREMWLYHTPARIEAPALAFL 476

  Fly   202 APNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSL 266
            ..||..|.:....|..: |...|.|..|..|.|..                  :|....|..:.:
Zfish   477 RENLTSLHIKFTDIKEI-PLWIYSLKNLSELHLTG------------------NLSAENNRFIVI 522

  Fly   267 DGDCLGHLQKLRTLRLEGNL--FYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLL 329
            ||  |..|::|:.|||:.||  ..::.|:....|:.|...|.|:.|:.:
Zfish   523 DG--LRELKRLKVLRLKSNLTKLPQVVTDVGVHLQKLSINNEGTKLMVL---------------- 569

  Fly   330 LKRNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSM 394
               |.:.|     :.|||.|::|..|   :..:|..:..|..|||:.:..|.|:.|.:
Zfish   570 ---NSLKK-----MVNLTELELLCCD---LERIPHSIFSLHNLQEIDLKDNNLKTIEE------- 616

  Fly   395 QMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLC 459
                                              :.||..|   |.|..|||....|..:|..:.
Zfish   617 ----------------------------------IISFQHL---HRLVCLKLWYNQIAYIPIQIG 644

  Fly   460 RQTPRLKSLELKTNSLKRIP-NLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKA 523
            ..| .|:.|.|..|.:::|| .|..||.||.||||.|.:..|.. ....|:.|....::.|||:.
Zfish   645 TLT-NLERLYLNRNKIEKIPAQLFFCRKLRYLDLSHNNLTSIPA-DIGFLQNLQYFAVTANRIET 707

  Fly   524 LPQDAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELP----------ESGLR 578
            ||.:.|| ..||:.|:| ||.........|...:.|..|.|..|....||          .|||
Zfish   708 LPPELFQ-CKKLRTLNL-GNNCLTALPSRFGELSGLTQLELRGNRLEGLPVELSECRLLKRSGL- 769

  Fly   579 ALLHLKTFNN--PKLRE 593
             ::....||.  |:|:|
Zfish   770 -IVEEDLFNTLPPELKE 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	47/212 (22%)
		leucine-rich repeat	183..204	CDD:275380	5/28 (18%)
		LRR_8	203..263	CDD:290566	12/59 (20%)
		leucine-rich repeat	205..228	CDD:275380	6/22 (27%)
		leucine-rich repeat	229..252	CDD:275380	3/22 (14%)
		LRR_8	252..311	CDD:290566	17/60 (28%)
		leucine-rich repeat	253..276	CDD:275380	6/22 (27%)
		leucine-rich repeat	277..300	CDD:275380	8/24 (33%)
		LRR_8	299..359	CDD:290566	12/59 (20%)
		leucine-rich repeat	301..324	CDD:275380	4/22 (18%)
		leucine-rich repeat	325..348	CDD:275380	4/22 (18%)
		LRR_RI	327..567	CDD:238064	63/240 (26%)
		leucine-rich repeat	349..371	CDD:275380	5/21 (24%)
		LRR_8	370..425	CDD:290566	6/54 (11%)
		leucine-rich repeat	372..393	CDD:275380	6/20 (30%)
		leucine-rich repeat	394..415	CDD:275380	0/20 (0%)
		leucine-rich repeat	418..486	CDD:275380	19/68 (28%)
		leucine-rich repeat	441..464	CDD:275378	7/22 (32%)
		LRR_8	487..545	CDD:290566	23/57 (40%)
		leucine-rich repeat	487..510	CDD:275380	9/22 (41%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	18/67 (27%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	9/30 (30%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
lrrc8aa	NP_001025120.1	Pannexin_like	1..325	CDD:289311
		leucine-rich repeat	401..432	CDD:275380	4/32 (13%)
		leucine-rich repeat	433..455	CDD:275380	8/29 (28%)
		LRR_RI	457..772	CDD:238064	100/412 (24%)
		leucine-rich repeat	480..502	CDD:275380	6/22 (27%)
		leucine-rich repeat	503..530	CDD:275380	9/46 (20%)
		LRR_8	577..636	CDD:290566	22/105 (21%)
		leucine-rich repeat	578..600	CDD:275380	7/24 (29%)
		leucine-rich repeat	601..625	CDD:275380	9/67 (13%)
		leucine-rich repeat	626..648	CDD:275380	7/22 (32%)
		LRR_8	647..705	CDD:290566	21/59 (36%)
		leucine-rich repeat	649..671	CDD:275380	8/21 (38%)
		leucine-rich repeat	672..694	CDD:275380	9/22 (41%)
		LRR_8	694..751	CDD:290566	19/58 (33%)
		leucine-rich repeat	695..717	CDD:275380	8/22 (36%)
		leucine-rich repeat	718..740	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910