DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Lrig3

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_796126.4	Gene:	Lrig3 / 320398	MGIID:	2443955	Length:	1117	Species:	Mus musculus

Alignment Length:	644	Identity:	148/644 - (22%)
Similarity:	245/644 - (38%)	Gaps:	169/644 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |||.|.|    |.|....::.:|..||..|..|||.:|.|:.::.:|.....:|:|:.|::|.
Mouse    51 CHCLGDL----LDCSRRRLVRLPDPLPAWVTRLDLSHNRLSFIQTSSLSHLQSLQEVKLNNNE-- 109

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
                                  |:::|        .|.|:..|                 :|.|.
Mouse   110 ----------------------LETIP--------NLGSISAN-----------------IRQLS 127

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
            |.||...:|....|...::||.|:|.:|.::.:... ||.: .|..|.:..|::..:..|...||
Mouse   128 LAGNAIDKILPEQLEAFQSLETLDLSNNNISELRTA-FPPL-QLKYLYINNNRVSSMEPGYFDNL 190

  Fly   347 -TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELP--RSMQMLDMRANPLSTIS 408
             :.|.||:|:.|.||::|..:.||.|||.|.:..|:::.::.....  .:::.|.|:.|.::.:.
Mouse   191 ASTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 255

  Fly   409 PGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELKTN 473
            .|||.|:|.                       :|:|:||...:.|:..........|:.|.|..|
Mouse   256 DGAFWGLSN-----------------------MEVLQLDHNNLTEITKGWLYGLLMLRELHLSQN 297

  Fly   474 SLKRI-PNL-SSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQ 536
            ::.|| |:. ..|:.|..|||:.|.:.::....|.||..||.|.:..|::..:...||:|:..|:
Mouse   298 AINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNALHIGNNKVSYIADCAFRGLTSLK 362

  Fly   537 LLDLEGNEISY---------------------------IHKEAFSGFTALEDLNLGNNIFPELPE 574
            .|||..||||:                           |.|:||:|...||.|:|..|....|..
Mouse   363 TLDLRNNEISWTIEDMSGAFSGLDRLRQLILQGNRIRSITKKAFAGLDTLEHLDLSGNAIMSLQS 427

  Fly   575 SGLRAL-----LHLKTFN---NPKLREFPPPDTFPRIQTLILSYAYH-----------------C 614
            :....:     |||.|.:   :.:||..|........|:.:.:...|                 .
Mouse   428 NAFSQMKKLQQLHLNTSSLLCDCQLRWLPQWVAENNFQSFVNASCAHPQLLKGRSIFTVSPDGFV 492

  Fly   615 CAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAI 679
            |...|...::.|.:|    ::.:..||..|..:                   ..:|...|...|.
Mouse   493 CDDFPKPQITVQPET----QSAIKGSDVSFTCS-------------------AASSSDSPMTFAW 534

  Fly   680 NFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCL 738
            ..:.|.||        .:.||.|.......|....|   |.:....:.|....|..||:
Mouse   535 KKDNEALQ--------DAEMENYAHLRAQGGELMEY---TTILRLRNVEFTSEGKYQCV 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/20 (25%)
		LRR_RI	180..>383	CDD:238064	51/203 (25%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	9/59 (15%)
		leucine-rich repeat	205..228	CDD:275380	4/22 (18%)
		leucine-rich repeat	229..252	CDD:275380	2/22 (9%)
		LRR_8	252..311	CDD:290566	15/58 (26%)
		leucine-rich repeat	253..276	CDD:275380	3/22 (14%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	18/60 (30%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	6/23 (26%)
		LRR_RI	327..567	CDD:238064	73/271 (27%)
		leucine-rich repeat	349..371	CDD:275380	10/21 (48%)
		LRR_8	370..425	CDD:290566	13/56 (23%)
		leucine-rich repeat	372..393	CDD:275380	4/22 (18%)
		leucine-rich repeat	394..415	CDD:275380	6/20 (30%)
		leucine-rich repeat	418..486	CDD:275380	13/69 (19%)
		leucine-rich repeat	441..464	CDD:275378	5/22 (23%)
		LRR_8	487..545	CDD:290566	20/57 (35%)
		leucine-rich repeat	487..510	CDD:275380	8/22 (36%)
		leucine-rich repeat	511..534	CDD:275380	7/22 (32%)
		LRR_8	533..589	CDD:290566	23/90 (26%)
		leucine-rich repeat	535..558	CDD:275380	13/49 (27%)
		leucine-rich repeat	559..580	CDD:275380	6/20 (30%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrig3	NP_796126.4	LRR 1	75..98		7/22 (32%)
		LRR_8	76..133	CDD:290566	21/105 (20%)
		leucine-rich repeat	76..99	CDD:275378	7/22 (32%)
		LRR_RI	81..324	CDD:238064	74/316 (23%)
		LRR 2	99..120		8/52 (15%)
		leucine-rich repeat	100..146	CDD:275378	16/94 (17%)
		LRR_8	122..179	CDD:290566	18/75 (24%)
		LRR 3	122..143		8/37 (22%)
		LRR 4	146..168		7/23 (30%)
		leucine-rich repeat	147..168	CDD:275380	7/22 (32%)
		LRR_8	168..227	CDD:290566	21/58 (36%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		LRR 5	169..189		4/19 (21%)
		LRR 6	193..214		8/20 (40%)
		leucine-rich repeat	194..216	CDD:275380	10/21 (48%)
		LRR_8	215..275	CDD:290566	17/82 (21%)
		LRR 7	216..237		5/20 (25%)
		leucine-rich repeat	217..240	CDD:275380	4/22 (18%)
		LRR 8	240..261		6/20 (30%)
		leucine-rich repeat	241..264	CDD:275380	7/22 (32%)
		LRR_RI	262..>446	CDD:238064	52/206 (25%)
		LRR_8	263..323	CDD:290566	19/82 (23%)
		LRR 9	264..285		5/43 (12%)
		leucine-rich repeat	265..288	CDD:275380	5/22 (23%)
		LRR 10	288..309		7/20 (35%)
		leucine-rich repeat	289..312	CDD:275380	8/22 (36%)
		LRR_8	312..371	CDD:290566	20/58 (34%)
		LRR 11	312..333		6/20 (30%)
		leucine-rich repeat	313..336	CDD:275380	8/22 (36%)
		LRR 12	336..357		6/20 (30%)
		leucine-rich repeat	337..360	CDD:275380	7/22 (32%)
		LRR_8	359..422	CDD:290566	18/62 (29%)
		LRR 13	360..382		8/21 (38%)
		leucine-rich repeat	361..385	CDD:275380	8/23 (35%)
		LRR 14	387..408		4/20 (20%)
		leucine-rich repeat	388..411	CDD:275380	5/22 (23%)
		LRR 15	411..432		6/20 (30%)
		leucine-rich repeat	412..433	CDD:275380	6/20 (30%)
		LRRCT	446..494	CDD:214507	5/47 (11%)
		I-set	499..599	CDD:254352	21/118 (18%)
		Ig	500..587	CDD:299845	21/117 (18%)
		I-set	603..693	CDD:254352
		Ig_1	620..694	CDD:143240
		I-set	697..784	CDD:254352
		IGc2	711..774	CDD:197706
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910