DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Tlr7

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_017457568.1	Gene:	Tlr7 / 317468	RGDID:	1563357	Length:	1068	Species:	Rattus norvegicus

Alignment Length:	989	Identity:	210/989 - (21%)
Similarity:	342/989 - (34%)	Gaps:	312/989 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 RWLQKHCHCTGSLEVLR----LSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLE 206
            ||..|...|..||:...    :.|....:..:|..:|.....|.|..|::..:..:||....:||
  Rat    46 RWYPKTLPCDVSLDSTNTHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFHRLKHLE 110

  Fly   207 ELTLSDNSI--------------INMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQ 257
            ||.|..|.:              :.:.|.:|.||:.||.|.|....|..: ||......||.||:
  Rat   111 ELDLRCNCVPILLGSKANVCTKRLQIRPGSFSGLSDLKSLYLDGNQLLEI-PQDLPSSLQLLSLE 174

  Fly   258 LNGNALVSLDGDCLGHLQKLRTLRLEGNLFYRIPTN--------ALAGLRTLEALNLGSNLLTI- 313
            .|.  :.|:..:.|..|..:.:|.|..|.:||.|.|        |...::.|:.|:|..|.:|.
  Rat   175 ANN--IFSITKENLSELVNIESLYLGQNCYYRNPCNVSYSIEKDAFLVMKNLKVLSLKDNNVTAV 237

  Fly   314 --------------------INDEDFPRMPNLIVLLL-----------------KRNQIMKISAG 341
                                |.:.||.::..|.||.|                 :.|..::|...
  Rat   238 PTILPPNLLELYLYNNIIKRIQEHDFNKLSQLQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDN 302

  Fly   342 ALKNLTALKVLELDDNLISSLP-EGLSKLSQLQELSITSNRL-------RWINDTELPRSMQMLD 398
            |..:||.||||.|..|.:..:| |....:|.||||.::.|.|       :::|  .||..:| ||
  Rat   303 AFDSLTELKVLRLHSNSLQHVPAEWFKNMSNLQELDLSQNYLAREIEEAKFLN--SLPNLVQ-LD 364

  Fly   399 MRAN------PLSTISPGAFRGMSKLRKLILSD--VRTLR--SFPELEACHALEILKLDRAGIQE 453
            :..|      ..|...|.:...::||:.|.:..  .:.|:  |...|.....||:|.|....|:.
  Rat   365 LSFNYELQVYHASITLPHSLSSLTKLKNLYIKGYVFKELKDSSLSVLHNLSNLEVLDLGTNFIKI 429

  Fly   454 VPANLCRQTPRLKSLELKTNSLK---------RIPNLS------------------------SCR 485
            ...|:.:|...||.::|..|.:.         ..||..                        |||
  Rat   430 ADLNIFQQFENLKFIDLSVNKISPSEESREVGLCPNAQTSVDWHGPQVLEALHYFRYDEYARSCR 494

  Fly   486 --------------DL----RLLDLSSNQIEKIQ--------------------GKPFNG----- 507
                          |.    :.||||.|.|..|:                    |:..||
  Rat   495 FKNKEPPTFLPLNADCHTYGKTLDLSRNNIFFIKPSDFKHLSFLKCLNLSGNAIGQTLNGSELQP 559

  Fly   508 LKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGNEISYIHKEAFS---GFTA----LEDLNLG 565
            |::|..|..|.||:..|...||:.:..|::|||..|. .|...|..:   .||.    ||.|.:.
  Rat   560 LRELRYLDFSNNRLDLLYSTAFEELQNLEILDLSSNS-HYFQAEGITHMLNFTKKLRHLEKLMMN 623

  Fly   566 NNIFP-----ELPESGLRAL----------------LHLKTFNN-PKLREFP---------PPDT 599
            :|...     .:....||.|                .:|..|.| ..|.|..         ||..
  Rat   624 DNDISTSASRTMESESLRVLEFRGNHLDVLWRDGDNRYLDFFKNLLNLEELDISRNSLNSVPPGV 688

  Fly   600 F----PRIQTLIL------SYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMM 654
            |    |.:.||.|      |:::.....|..:.                      ::.|.:|.:.
  Rat   689 FEGMPPNLTTLSLAKNGLRSFSWGRLQLLKHLK----------------------NLDLSHNQLT 731

  Fly   655 NIWPQMHNLSKQLGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEH--DVSGPATGYGF 717
            .:..::.|.||.|         |.:..|..|::     |:...::|:..:..  |:|
  Rat   732 TVPARLANCSKSL---------TKLILNHNQIR-----QLTKYFLEDALQLRYLDIS-------- 774

  Fly   718 GTGLFSGMSTEDFQPGSVQCLPM----PGPFLPCADL--FDWWTLRCGVWVVFL---LSLLG--- 770
             :.....:....|....:..|.|    ...||...|.  |.||.....|.:.:|   ::..|
  Rat   775 -SNKIQVIQKTSFPENVLNNLNMLLLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCAGPGA 838

  Fly   771 -NGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYLGILAIVDAATLGEFRMFAIP--WQMSVL 832
             .|..|..|.....::|:...::.:::.:.     .|.::.::..:.|..:.|:.|.  |:
  Rat   839 HKGQSVISLDLYTCELDLTNLILFSVSISS-----VLFLMIVMTTSHLFFWDMWYIYYFWK---- 894

  Fly   833 CQLSGFLAVLSSELSVYTLAVITLERNYAITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLV 897
            .::.|:..:.|.| |.|...::...:|.|:|.                    ||...:     :|
  Rat   895 AKIKGYQHLQSME-SCYDAFIVYDTKNSAVTE--------------------WVLQEL-----VV 933

  Fly   898 GVSDYRK--FAVCL 909
            .:.|.|:  |.:||
  Rat   934 KLEDPREKHFNLCL 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	3/24 (13%)
		LRR_RI	180..>383	CDD:238064	70/270 (26%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	22/73 (30%)
		leucine-rich repeat	205..228	CDD:275380	10/36 (28%)
		leucine-rich repeat	229..252	CDD:275380	7/22 (32%)
		LRR_8	252..311	CDD:290566	20/66 (30%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	8/30 (27%)
		LRR_8	299..359	CDD:290566	23/97 (24%)
		leucine-rich repeat	301..324	CDD:275380	8/43 (19%)
		leucine-rich repeat	325..348	CDD:275380	8/39 (21%)
		LRR_RI	327..567	CDD:238064	86/357 (24%)
		leucine-rich repeat	349..371	CDD:275380	8/22 (36%)
		LRR_8	370..425	CDD:290566	19/67 (28%)
		leucine-rich repeat	372..393	CDD:275380	9/27 (33%)
		leucine-rich repeat	394..415	CDD:275380	6/26 (23%)
		leucine-rich repeat	418..486	CDD:275380	21/118 (18%)
		leucine-rich repeat	441..464	CDD:275378	7/22 (32%)
		LRR_8	487..545	CDD:290566	24/86 (28%)
		leucine-rich repeat	487..510	CDD:275380	11/51 (22%)
		leucine-rich repeat	511..534	CDD:275380	8/22 (36%)
		LRR_8	533..589	CDD:290566	19/84 (23%)
		leucine-rich repeat	535..558	CDD:275380	8/25 (32%)
		leucine-rich repeat	559..580	CDD:275380	6/25 (24%)
		7tm_4	764..>892	CDD:304433	21/136 (15%)
		7tm_1	770..1017	CDD:278431	26/148 (18%)
Tlr7	XP_017457568.1	leucine-rich repeat	66..87	CDD:275380	3/20 (15%)
		LRR_8	93..157	CDD:290566	17/63 (27%)
		leucine-rich repeat	109..146	CDD:275380	10/36 (28%)
		leucine-rich repeat	147..191	CDD:275380	15/46 (33%)
		leucine-rich repeat	192..223	CDD:275380	8/30 (27%)
		LRR_8	222..277	CDD:290566	12/54 (22%)
		LRR_RI	223..472	CDD:238064	60/251 (24%)
		leucine-rich repeat	224..244	CDD:275380	5/19 (26%)
		leucine-rich repeat	245..268	CDD:275380	3/22 (14%)
		leucine-rich repeat	269..309	CDD:275380	8/39 (21%)
		LRR_8	308..368	CDD:290566	22/62 (35%)
		leucine-rich repeat	310..333	CDD:275380	8/22 (36%)
		leucine-rich repeat	334..359	CDD:275380	8/26 (31%)
		leucine-rich repeat	370..389	CDD:275380	2/18 (11%)
		leucine-rich repeat	390..416	CDD:275380	5/25 (20%)
		leucine-rich repeat	417..440	CDD:275380	7/22 (32%)
		LRR_8	515..573	CDD:290566	15/57 (26%)
		leucine-rich repeat	515..537	CDD:275380	7/21 (33%)
		LRR_RI	532..778	CDD:238064	55/291 (19%)
		leucine-rich repeat	538..562	CDD:275380	4/23 (17%)
		LRR_8	561..627	CDD:290566	21/66 (32%)
		leucine-rich repeat	563..586	CDD:275380	8/22 (36%)
		leucine-rich repeat	587..616	CDD:275380	9/29 (31%)
		leucine-rich repeat	617..639	CDD:275380	4/21 (19%)
		LRR_8	639..706	CDD:290566	15/66 (23%)
		leucine-rich repeat	640..670	CDD:275380	6/29 (21%)
		leucine-rich repeat	671..695	CDD:275380	5/23 (22%)
		LRR_8	694..754	CDD:290566	14/90 (16%)
		leucine-rich repeat	696..719	CDD:275380	5/22 (23%)
		leucine-rich repeat	720..743	CDD:275380	4/44 (9%)
		leucine-rich repeat	768..786	CDD:275380	2/26 (8%)
		TIR	909..1054	CDD:214587	12/64 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910