DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rk and Tlr13

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_038956543.1	Gene:	Tlr13 / 317227	RGDID:	1562655	Length:	956	Species:	Rattus norvegicus

Alignment Length:	1002	Identity:	215/1002 - (21%)
Similarity:	336/1002 - (33%)	Gaps:	343/1002 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 VVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQN--------- 236
            :.:|:|..|.:..:. |||....|||.|.||.|.|.::..:||..|.|||.|||..
  Rat   118 LTLLNLVENKIQSVN-NSFEGLSNLETLLLSHNQITHIHKDAFTPLVKLKYLSLSRNRISNFSGI 181

  Fly   237 --------C-------------------GLKSLPPQSFQG------------------------- 249
                    |                   .|.||...||:|
  Rat   182 LEAVQHLPCLEHLDLINNSIMYLDHSPRSLVSLTHLSFEGNNLTELNFSTLSLPNLTNLSASQNG 246

  Fly   250 -----------LAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRL------EGNL----------- 286
                       |.||.||.|:| .:|.|:.....|||.:|.:.|      .|:|
  Rat   247 HGVIQDVYLKTLPQLQSLNLSG-TVVKLEMLSAKHLQNVRVMDLSNRELKHGHLNMKIVCYLLRN 310

  Fly   287 --------FYRIPTNA-----LAGLRTLEALNLGSNL-LTIINDEDFPRMPNLIVLLLKRNQIMK 337
                    |::..|||     ||....|..|:||.|. |..:||.:|..:|:|..|.|.:.|:..
  Rat   311 LPMLEILFFHKNATNAEGIKQLAKCTRLLFLDLGQNSDLVHLNDSEFNALPSLQRLNLNKCQLSF 375

  Fly   338 ISAGALKNLTALKVLELDDNLISSLPE-GLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRA 401
            ||.....:|..|.:|:|..|...|.|: ..|.|.:|:.||::                      .
  Rat   376 ISNKTWSSLQNLTILDLSHNKFKSFPDFAFSPLKRLEFLSLS----------------------R 418

  Fly   402 NPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLK 466
            ||::.::..||.|:..|::|            .|.||.   |:.:||....:.|
  Rat   419 NPITELNNLAFSGLFSLKEL------------NLAACW---IVTIDRYSFTQFP----------- 457

  Fly   467 SLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQG 531
                               :|.:|||..|.|..:....|..||:|:.|:||:||::.:..:||.|
  Rat   458 -------------------NLEVLDLGDNNIRTLNHGTFQPLKKLHTLILSHNRLEIMESNAFSG 503

  Fly   532 IPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPP 596
            :..|:.|||..|.:||.||..|.|...|..|.||.|..               |:...:..::||
  Rat   504 LTGLRYLDLMYNSLSYFHKHHFMGLEKLLVLKLGFNKI---------------TYETTRTLQYPP 553

  Fly   597 PDTFPRIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVL------FPSDAEFD---------- 645
            ......::.|.|....|   .:.:|..:..:..|.:||.:|      |....:||
  Rat   554 FMKLKSLKQLNLEGQKH---GIQVVPRNFFQGLSSLQELLLGKNPSVFLDHHQFDPLINLTKLDI 615

  Fly   646 -------------------------MTLWNNSMMNIWPQMHNLSKQLGASMHDPWETAINFNEEQ 685
                                     :.|.||::.::.|.|.       :|:.:....::.||..:
  Rat   616 SGTKDGDRSLYLNSSLFQNLKRLKVLRLENNNLESLVPGMF-------SSLQNLQVFSLRFNNLK 673

  Fly   686 LQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQPGSVQCLPMPGPFL---PC 747
            :..|:..:...|.|  :|   ||        :|..|........|:..|:....:..|||   ||
  Rat   674 VINQSHLENLKSLM--FF---DV--------YGNKLQCTCDNLWFKNWSMNTEEVHIPFLRSYPC 725

  Fly   748 AD------LFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLAAADFFMGIYL 806
            ..      |.|:....|.    |.|     |.|.|  |||.|       :|.:.....:|..
  Rat   726 QQPNSQSLLIDFDDAMCN----FDL-----GKVYF--LCSFS-------VVLSTMVFSWFSA--- 769

  Fly   807 GILAIVDAATLGEFRMFAIPWQMSVLCQ---------------LSGFLAV-LSSELSVYTLAVIT 855
                          :|.|..|....:|:               ...|::. .:.|..||...|..
  Rat   770 --------------KMIASLWYGLYICRAWYLTKWHKTEKKFLYDAFVSFSATDEAWVYKELVPA 820

  Fly   856 LERNYAITHAIHLNKRLSLKQAGYIMSVGWVF-----ALIMALMPLVGVSDYRKFAVCLPFETTT 915
            ||.....|.      :|.|.|..:...:. :|     |:..:...|..||::...:.....|...
  Rat   821 LEEGSQTTF------KLCLHQRDFEPGID-IFENIQNAINASRKTLCVVSNHYLHSEWCRLEVQL 878

  Fly   916 GPASLTY----VISLMFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTDFLCW 976
            ....:.|    ||.|:|:.     .:....|..|..:|          ::..|...:.:.|....
  Rat   879 ASMKMFYEHKDVIILIFLE-----EIPNYKLSSYHRLR----------KLINRQTFITWPDSAHQ 928

  Fly   977 SPIAFFSITAIFGLQLISLEQAKIFTV 1003
            .|:.:..|....|.:.:..|...:..|
  Rat   929 QPLFWARIRNALGNETVEKENTHLIVV 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380
		LRR_RI	180..>383	CDD:238064	80/305 (26%)
		leucine-rich repeat	183..204	CDD:275380	6/20 (30%)
		LRR_8	203..263	CDD:290566	31/131 (24%)
		leucine-rich repeat	205..228	CDD:275380	10/22 (45%)
		leucine-rich repeat	229..252	CDD:275380	13/94 (14%)
		LRR_8	252..311	CDD:290566	26/89 (29%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	10/52 (19%)
		LRR_8	299..359	CDD:290566	21/60 (35%)
		leucine-rich repeat	301..324	CDD:275380	9/23 (39%)
		leucine-rich repeat	325..348	CDD:275380	7/22 (32%)
		LRR_RI	327..567	CDD:238064	64/240 (27%)
		leucine-rich repeat	349..371	CDD:275380	8/22 (36%)
		LRR_8	370..425	CDD:290566	10/54 (19%)
		leucine-rich repeat	372..393	CDD:275380	3/20 (15%)
		leucine-rich repeat	394..415	CDD:275380	4/20 (20%)
		leucine-rich repeat	418..486	CDD:275380	9/67 (13%)
		leucine-rich repeat	441..464	CDD:275378	4/22 (18%)
		LRR_8	487..545	CDD:290566	23/57 (40%)
		leucine-rich repeat	487..510	CDD:275380	8/22 (36%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	17/55 (31%)
		leucine-rich repeat	535..558	CDD:275380	11/22 (50%)
		leucine-rich repeat	559..580	CDD:275380	5/20 (25%)
		7tm_4	764..>892	CDD:304433	28/148 (19%)
		7tm_1	770..1017	CDD:278431	45/259 (17%)
Tlr13	XP_038956543.1	leucine-rich repeat	47..69	CDD:275380
		leucine-rich repeat	70..93	CDD:275380
		PLN00113	72..>518	CDD:215061	117/468 (25%)
		leucine-rich repeat	94..117	CDD:275380
		leucine-rich repeat	118..140	CDD:275380	6/22 (27%)
		leucine-rich repeat	141..164	CDD:275380	10/22 (45%)
		leucine-rich repeat	165..190	CDD:275380	5/24 (21%)
		leucine-rich repeat	191..213	CDD:275380	1/21 (5%)
		leucine-rich repeat	214..236	CDD:275380	4/21 (19%)
		leucine-rich repeat	237..260	CDD:275380	1/22 (5%)
		leucine-rich repeat	261..283	CDD:275380	9/22 (41%)
		leucine-rich repeat	338..362	CDD:275380	9/23 (39%)
		PLN00113	360..>710	CDD:215061	98/454 (22%)
		leucine-rich repeat	363..386	CDD:275380	7/22 (32%)
		leucine-rich repeat	387..410	CDD:275380	8/22 (36%)
		leucine-rich repeat	411..434	CDD:275380	8/44 (18%)
		leucine-rich repeat	435..458	CDD:275380	9/67 (13%)
		leucine-rich repeat	459..482	CDD:275380	8/22 (36%)
		leucine-rich repeat	483..506	CDD:275380	9/22 (41%)
		leucine-rich repeat	507..530	CDD:275380	11/22 (50%)
		leucine-rich repeat	531..585	CDD:275380	12/71 (17%)
		leucine-rich repeat	638..661	CDD:275380	6/29 (21%)
		leucine-rich repeat	662..683	CDD:275380	3/20 (15%)
		TIR	799..943	CDD:214587	30/165 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910