DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Lrig1

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_232237.6	Gene:	Lrig1 / 312574	RGDID:	1306788	Length:	1096	Species:	Rattus norvegicus

Alignment Length:	483	Identity:	135/483 - (27%)
Similarity:	208/483 - (43%)	Gaps:	78/483 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216
            |.|.|.    .|.|.|.|:..:|.::|:....|:|..|.|::::..:|....||:|:.|:.|.:
  Rat    50 CTCAGD----SLDCSGRGLATLPRDMPSWTRSLNLSYNRLSEIDPAAFEDLTNLQEVYLNSNEL- 109

  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281
                           .::.:.|..|:         .:.||.|..|.::|:||
  Rat   110 ---------------TAVPSLGAASM---------HVVSLFLQHNKILSVDG------------- 137

  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346
                       :.|....:||.|:|.||.:|.|....||....:..|.|..|:|..:.:||...|
  Rat   138 -----------SQLKSYLSLEVLDLSSNNITEIRSSCFPNGLRVRELNLASNRISILESGAFDGL 191

  Fly   347 T-ALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELP--RSMQMLDMRANPLSTIS 408
            : :|..|.|..|.|:.||....||.:|.:|.:..||:|.|......  .|:::|.::.|.||.::
  Rat   192 SRSLLTLRLSKNRITQLPVKAFKLPRLTQLDLNRNRIRLIEGLTFQGLDSLEVLKLQRNNLSKLT 256

  Fly   409 PGAFRGMSKLRKLILS-----DVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSL 468
            .|||.|:||:..|.|.     :|.: .|...|.|.|.|.:.....:.||....:.|:   :|..|
  Rat   257 DGAFWGLSKMHVLHLEYNSLVEVNS-GSLYGLTALHQLHLSNNSISRIQRDGWSFCQ---KLHEL 317

  Fly   469 ELKTNSLKRI--PNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQD---A 528
            .|..|:|.|:  .:|:....|.:|.||.|.|..|....|.|||.|..|.|.:|.|....:|   |
  Rat   318 ILSFNNLTRLDEESLAELSGLSILRLSHNAISHIAEGAFKGLKSLRVLELDHNEISGTIEDTSGA 382

  Fly   529 FQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFN------ 587
            |.|:..|..|.|.||:|..:.|.||||...||.||||.|....:.......:.:||...
  Rat   383 FMGLDNLSKLTLFGNKIKSVAKRAFSGLENLEHLNLGENAIRSIQFDAFAKMKNLKELYISSESF 447

  Fly   588 --NPKLREFPPPDTFPRIQTLILSYAYH 613
              :.:|:..||......:|..:.:...|
  Rat   448 LCDCQLKWLPPWLVSRMLQAFVTATCAH 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	5/20 (25%)
		LRR_RI	180..>383	CDD:238064	50/203 (25%)
		leucine-rich repeat	183..204	CDD:275380	5/20 (25%)
		LRR_8	203..263	CDD:290566	11/59 (19%)
		leucine-rich repeat	205..228	CDD:275380	4/22 (18%)
		leucine-rich repeat	229..252	CDD:275380	2/22 (9%)
		LRR_8	252..311	CDD:290566	14/58 (24%)
		leucine-rich repeat	253..276	CDD:275380	7/22 (32%)
		leucine-rich repeat	277..300	CDD:275380	1/22 (5%)
		LRR_8	299..359	CDD:290566	21/60 (35%)
		leucine-rich repeat	301..324	CDD:275380	10/22 (45%)
		leucine-rich repeat	325..348	CDD:275380	7/23 (30%)
		LRR_RI	327..567	CDD:238064	88/252 (35%)
		leucine-rich repeat	349..371	CDD:275380	9/21 (43%)
		LRR_8	370..425	CDD:290566	19/61 (31%)
		leucine-rich repeat	372..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..415	CDD:275380	7/20 (35%)
		leucine-rich repeat	418..486	CDD:275380	18/74 (24%)
		leucine-rich repeat	441..464	CDD:275378	4/22 (18%)
		LRR_8	487..545	CDD:290566	25/60 (42%)
		leucine-rich repeat	487..510	CDD:275380	10/22 (45%)
		leucine-rich repeat	511..534	CDD:275380	9/25 (36%)
		LRR_8	533..589	CDD:290566	20/63 (32%)
		leucine-rich repeat	535..558	CDD:275380	11/22 (50%)
		leucine-rich repeat	559..580	CDD:275380	7/20 (35%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Lrig1	XP_232237.6	LRR_8	76..132	CDD:290566	16/80 (20%)
		LRR_4	76..115	CDD:289563	10/54 (19%)
		leucine-rich repeat	76..98	CDD:275380	5/21 (24%)
		leucine-rich repeat	99..114	CDD:275380	4/30 (13%)
		leucine-rich repeat	122..145	CDD:275380	8/46 (17%)
		LRR_RI	138..421	CDD:238064	99/286 (35%)
		LRR_8	145..228	CDD:290566	29/82 (35%)
		leucine-rich repeat	146..169	CDD:275380	10/22 (45%)
		leucine-rich repeat	170..193	CDD:275380	7/22 (32%)
		leucine-rich repeat	194..217	CDD:275380	9/22 (41%)
		LRR_8	216..276	CDD:290566	19/59 (32%)
		leucine-rich repeat	218..241	CDD:275380	6/22 (27%)
		leucine-rich repeat	242..265	CDD:275380	8/22 (36%)
		LRR_8	264..324	CDD:290566	17/63 (27%)
		leucine-rich repeat	266..289	CDD:275380	5/23 (22%)
		leucine-rich repeat	290..313	CDD:275380	5/25 (20%)
		LRR_8	313..372	CDD:290566	22/58 (38%)
		leucine-rich repeat	314..337	CDD:275380	7/22 (32%)
		leucine-rich repeat	338..361	CDD:275380	10/22 (45%)
		leucine-rich repeat	362..386	CDD:275380	8/23 (35%)
		LRR_8	388..444	CDD:290566	20/55 (36%)
		leucine-rich repeat	389..412	CDD:275380	11/22 (50%)
		LRR_4	411..>444	CDD:289563	9/32 (28%)
		leucine-rich repeat	413..434	CDD:275380	7/20 (35%)
		LRRCT	447..495	CDD:214507	5/29 (17%)
		I-set	500..600	CDD:254352
		Ig	517..591	CDD:143165
		I-set	604..694	CDD:254352
		Ig_1	621..695	CDD:143240
		I-set	698..785	CDD:254352
		IGc2	712..775	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910