DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Nepn

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	XP_006256553.1	Gene:	Nepn / 309775	RGDID:	1307755	Length:	512	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	129/453 - (28%)
Similarity:	200/453 - (44%)	Gaps:	93/453 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 WLQKH----CHCTGSLEVLRLSCRGI------GILAVPVNLPNEVVVLDLGN--------NNLTK 193
            ||...    .:|.|     |.||..:      .:|.||..:|:....|.:.:        :|||:
  Rat    10 WLSLSNVLGANCPG-----RCSCDSLQSVQCYRLLEVPSGIPSTTRRLYISHSRIQHLQLSNLTQ 69

  Fly   194 LEA---------------NSFF----------------------MAPNLEELTLSDNSIINMDPN 221
            |.|               |..|                      :..|||.|.|:||||..:..:
  Rat    70 LLALEDFILLASGTESIENDTFKTLTTLKTLELWKNKLRRVPSALPANLEVLKLNDNSICALHGS 134

  Fly   222 AFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLRLEGNL 286
            .|.||:.||.|.|:|..:.||.|.....|..|.||.::||.:.|:.|..  .|..|:.:.:|.|.
  Rat   135 DFEGLSNLKVLELKNNLISSLSPSMLSSLVSLQSLLVDGNNIESVTGPL--SLPNLKYMSMEKNK 197

  Fly   287 FYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNLTALKV 351
            .:.|..|....|:.|:.|:...|.||.| ..:.|:  :|:.|.::|||:..:....:::|..|..
  Rat   198 LHLISGNVFTSLQNLQFLSFSGNFLTKI-PINLPK--SLLSLKMERNQLKVVRFRDMRHLENLSH 259

  Fly   352 LELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQMLDMRANPLSTISPGAFRGMS 416
            |.|.:||:||: :|...|:.|..|..:.|||:.: ...||..:|.||..:|.:..::...|:.:.
  Rat   260 LYLSENLLSSI-DGAQLLTNLTTLEASQNRLQML-PPRLPSRLQKLDCSSNFIQRVTAPEFQDLR 322

  Fly   417 KLRKLILSDVRTLRSFPELEACHALEILKLDRAG-IQEVPANLCRQTPRLKSLELKTNSLKRIPN 480
            .|:.|.|.:                .::.|..|| :|:     |.|   |.:|.|:.|.|..||
  Rat   323 DLKHLFLDN----------------NVVSLFEAGALQK-----CSQ---LSNLALEQNLLLSIP- 362

  Fly   481 LSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQLLDLEGN 543
            |...:.|..|||..|.|:.:..:....||||..|.|..|:|.||...|.:|:|:|:.|.|:||
  Rat   363 LRLPKTLARLDLKGNAIQDMAERELRDLKQLQVLNLRNNKISALDLKALEGLPRLRHLYLDGN 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/26 (23%)
		LRR_RI	180..>383	CDD:238064	69/247 (28%)
		leucine-rich repeat	183..204	CDD:275380	8/65 (12%)
		LRR_8	203..263	CDD:290566	26/59 (44%)
		leucine-rich repeat	205..228	CDD:275380	11/22 (50%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		LRR_8	252..311	CDD:290566	17/58 (29%)
		leucine-rich repeat	253..276	CDD:275380	8/22 (36%)
		leucine-rich repeat	277..300	CDD:275380	6/22 (27%)
		LRR_8	299..359	CDD:290566	17/59 (29%)
		leucine-rich repeat	301..324	CDD:275380	7/22 (32%)
		leucine-rich repeat	325..348	CDD:275380	6/22 (27%)
		LRR_RI	327..567	CDD:238064	67/218 (31%)
		leucine-rich repeat	349..371	CDD:275380	9/21 (43%)
		LRR_8	370..425	CDD:290566	15/54 (28%)
		leucine-rich repeat	372..393	CDD:275380	7/20 (35%)
		leucine-rich repeat	394..415	CDD:275380	5/20 (25%)
		leucine-rich repeat	418..486	CDD:275380	17/68 (25%)
		leucine-rich repeat	441..464	CDD:275378	6/23 (26%)
		LRR_8	487..545	CDD:290566	24/57 (42%)
		leucine-rich repeat	487..510	CDD:275380	7/22 (32%)
		leucine-rich repeat	511..534	CDD:275380	9/22 (41%)
		LRR_8	533..589	CDD:290566	6/11 (55%)
		leucine-rich repeat	535..558	CDD:275380	5/9 (56%)
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Nepn	XP_006256553.1	leucine-rich repeat	50..72	CDD:275380	5/21 (24%)
		leucine-rich repeat	73..96	CDD:275380	2/22 (9%)
		leucine-rich repeat	118..141	CDD:275380	11/22 (50%)
		leucine-rich repeat	142..165	CDD:275380	9/22 (41%)
		leucine-rich repeat	166..187	CDD:275380	8/22 (36%)
		leucine-rich repeat	188..211	CDD:275380	6/22 (27%)
		leucine-rich repeat	212..235	CDD:275380	8/25 (32%)
		leucine-rich repeat	236..256	CDD:275380	5/19 (26%)
		LRR_RI	<251..425	CDD:238064	61/200 (31%)
		leucine-rich repeat	257..278	CDD:275380	9/21 (43%)
		leucine-rich repeat	279..299	CDD:275380	7/20 (35%)
		LRR_8	298..358	CDD:290566	18/83 (22%)
		leucine-rich repeat	300..323	CDD:275380	5/22 (23%)
		leucine-rich repeat	324..347	CDD:275380	8/43 (19%)
		leucine-rich repeat	348..371	CDD:275380	9/23 (39%)
		LRR_8	367..426	CDD:290566	24/59 (41%)
		leucine-rich repeat	372..392	CDD:275380	6/19 (32%)
		leucine-rich repeat	393..416	CDD:275380	9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910