DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rk and Tsku

DIOPT Version :9

Sequence 1:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster
Sequence 2:	NP_001009965.2	Gene:	Tsku / 308843	RGDID:	1359311	Length:	353	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	99/456 - (21%)
Similarity:	160/456 - (35%)	Gaps:	166/456 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CHCT-------GSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAP---NLE 206
            |.|.       .|..::|:.|..:|...|||.:|.:...|||.:|.|..:. .|....|   .|.
  Rat    25 CQCEEETFGLFDSFSLIRVDCSSLGPHIVPVPIPLDTAHLDLSSNRLETVN-ESVLGGPGYTTLA 88

  Fly   207 ELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNAL--VSLDGD 269
            .|.||.|.:.::.|.||..|..|:.|.|.:.||.:||.:.|.. :.|:.:.|:.|.|  ||:...
  Rat    89 GLDLSHNLLTSITPTAFSRLRYLESLDLSHNGLAALPAEVFTS-SPLSDINLSHNRLREVSISAF 152

  Fly   270 CLGHLQKLRTLRLEGNLFYRI---PTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLK 331
            ......:...:.|..||.:|:   |..|.....|:::|||..|.|..:        |||
  Rat   153 TTHSQGRALHVDLSHNLIHRLLPYPARASLSAPTIQSLNLSWNRLRAV--------PNL------ 203

  Fly   332 RNQIMKISAGALKNLTALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWINDTELPRSMQM 396
                                                                    .:||  ::.
  Rat   204 --------------------------------------------------------RDLP--LRY 210

  Fly   397 LDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQ 461
            |.:..|||:||:||||.|::.|..|.|:.::              .||:|...|.:|:|.
  Rat   211 LSLDGNPLATINPGAFMGLAGLTHLSLASLQ--------------GILQLPPHGFRELPG----- 256

  Fly   462 TPRLKSLELKTNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQ 526
                                     |::||||.|.                       ::|....
  Rat   257 -------------------------LQVLDLSGNP-----------------------KLKWAGA 273

  Fly   527 DAFQGIPKLQLLDLEGNEISYIHKEAFSGFTALEDLNLGNNI----------FPELPESGLRALL 581
            :.|.|:..||.|||.|:.:..:.:.......||:.:::|.::          :...|.|..:.:|
  Rat   274 EVFSGLGLLQELDLSGSSLVPLPETLLHHLPALQSVSVGQDVQCRRLVREGAYHRQPGSSPKVVL 338

  Fly   582 H 582
            |
  Rat   339 H 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	6/20 (30%)
		LRR_RI	180..>383	CDD:238064	45/210 (21%)
		leucine-rich repeat	183..204	CDD:275380	7/23 (30%)
		LRR_8	203..263	CDD:290566	21/62 (34%)
		leucine-rich repeat	205..228	CDD:275380	9/22 (41%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	17/63 (27%)
		leucine-rich repeat	253..276	CDD:275380	6/24 (25%)
		leucine-rich repeat	277..300	CDD:275380	6/25 (24%)
		LRR_8	299..359	CDD:290566	9/59 (15%)
		leucine-rich repeat	301..324	CDD:275380	5/22 (23%)
		leucine-rich repeat	325..348	CDD:275380	1/22 (5%)
		LRR_RI	327..567	CDD:238064	40/239 (17%)
		leucine-rich repeat	349..371	CDD:275380	0/21 (0%)
		LRR_8	370..425	CDD:290566	16/54 (30%)
		leucine-rich repeat	372..393	CDD:275380	2/20 (10%)
		leucine-rich repeat	394..415	CDD:275380	10/20 (50%)
		leucine-rich repeat	418..486	CDD:275380	9/67 (13%)
		leucine-rich repeat	441..464	CDD:275378	6/22 (27%)
		LRR_8	487..545	CDD:290566	15/57 (26%)
		leucine-rich repeat	487..510	CDD:275380	6/22 (27%)
		leucine-rich repeat	511..534	CDD:275380	3/22 (14%)
		LRR_8	533..589	CDD:290566	13/60 (22%)
		leucine-rich repeat	535..558	CDD:275380	6/22 (27%)
		leucine-rich repeat	559..580	CDD:275380	4/30 (13%)
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Tsku	NP_001009965.2	LRR	<39..286	CDD:227223	85/387 (22%)
		LRR 1	60..80		6/20 (30%)
		leucine-rich repeat	63..86	CDD:275380	7/23 (30%)
		LRR 2	86..107		8/20 (40%)
		leucine-rich repeat	90..110	CDD:275380	8/19 (42%)
		LRR 3	110..131		8/20 (40%)
		leucine-rich repeat	111..133	CDD:275380	8/22 (36%)
		LRR 4	133..154		6/20 (30%)
		leucine-rich repeat	134..159	CDD:275380	6/24 (25%)
		leucine-rich repeat	160..186	CDD:275380	6/25 (24%)
		LRR 5	160..180		5/19 (26%)
		LRR 6	186..207		9/90 (10%)
		leucine-rich repeat	187..205	CDD:275380	8/87 (9%)
		leucine-rich repeat	208..231	CDD:275380	11/22 (50%)
		LRR 7	208..228		10/19 (53%)
		LRR 8	231..253		7/35 (20%)
		leucine-rich repeat	232..256	CDD:275380	8/37 (22%)
		LRR 9	256..277		7/73 (10%)
		leucine-rich repeat	257..281	CDD:275380	9/46 (20%)
		LRR 10	281..302		6/20 (30%)
		leucine-rich repeat	282..305	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910